The Dictyostelium MAPK ERK1 is phosphorylated in a secondary response to early developmental signaling.

Abstract:

:Previous reports have suggested that the two mitogen-activated protein kinases (MAPKs) in Dictyostelium discoideum, ERK1 and ERK2, can be directly activated in response to external cAMP even though these MAPKs play different roles in the developmental life cycle. To better characterize MAPK regulation, the levels of phosphorylated MAPKs were analyzed in response to external signals. Only ERK2 was rapidly phosphorylated in response to the chemoattractants, cAMP and folate. In contrast, the phosphorylation of ERK1 occurred as a secondary or indirect response to these stimuli and this phosphorylation was enhanced by cell-cell interactions, suggesting that other external signals can activate ERK1. The phosphorylation of ERK1 or ERK2 did not require the function of the other MAPK in these responses. Folate stimulation of a chimeric population of erk1- and gα4- cells revealed that the phosphorylation of ERK1 could be mediated through an intercellular signal other than folate. Loss of ERK1 function suppressed the developmental delay and the deficiency in anterior cell localization associated with gα5- mutants suggesting that ERK1 function can be down regulated through Gα5 subunit-mediated signaling. However, no major changes in the phosphorylation of ERK1 were observed in gα5- cells suggesting that the Gα5 subunit signaling pathway does not regulate the phosphorylation of ERK1. These findings suggest that the activation of ERK1 occurs as a secondary response to chemoattractants and that other cell-cell signaling mechanisms contribute to this activation. Gα5 subunit signaling can down regulate ERK1 function to promote prestalk cell development but not through major changes to the level of phosphorylated ERK1.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Schwebs DJ,Hadwiger JA

doi

10.1016/j.cellsig.2014.10.009

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

147-55

issue

1

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(14)00345-3

journal_volume

27

pub_type

杂志文章
  • Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes.

    abstract::The present study was undertaken to investigate whether purified ras proteins can affect the activity of polyphosphoinositide specific phospholipase C in a cell-free membrane system. For this purpose we used homogenous preparations of the proto-oncogenic (H-ras(gly 12)) and the oncogenic (H-ras(val 12)) forms of the h...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/0898-6568(90)90050-k

    authors: Cockcroft S,Bar-Sagi D

    更新日期:1990-01-01 00:00:00

  • GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes.

    abstract::Glycogen synthase kinase 3beta (GSK3beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and the insulin response. GSK3beta also plays a key role in the Wnt/beta-catenin pathway. The master regulator of the pigmentation microphthalmia-associated transcription...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2008.06.001

    authors: Bellei B,Flori E,Izzo E,Maresca V,Picardo M

    更新日期:2008-10-01 00:00:00

  • Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system.

    abstract::Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in ma...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2008.07.011

    authors: Okada T,Kajimoto T,Jahangeer S,Nakamura S

    更新日期:2009-01-01 00:00:00

  • The presence of phorbol ester responsive and non-responsive forms of the zeta isozyme of protein kinase C in mouse epidermal cells.

    abstract::The possible involvement of zeta isozyme of protein kinase C (PKC zeta) in phorbol ester-induced signal transduction was investigated in mouse epidermal cells. Western blot analysis of RESOURCE Q column chromatography eluates obtained from 105,000 g supernatants and particulate fractions of epidermal cells was perform...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/0898-6568(95)00019-l

    authors: Nishikawa K,Yamamoto S,Nagumo H,Maruyama K,Kato R

    更新日期:1995-07-01 00:00:00

  • Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide.

    abstract::Inflammatory stimulus during development increases the risk for adverse neurologic outcome. One possible mechanism is disrupting neuronal migration. Using lipopolysaccharide (LPS)-treatment to assess inflammatory stimulus on neuronal migration of cerebellar granule neurons, we previously found that LPS-activation incr...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2010.10.017

    authors: Arias-Salvatierra D,Silbergeld EK,Acosta-Saavedra LC,Calderon-Aranda ES

    更新日期:2011-02-01 00:00:00

  • Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.

    abstract::Clinical studies have elucidated the negative correlation between microtubules-associated protein 1 light chain 3-B (LC3B) protein expression and overall survival of breast cancer patients. Our previous data demonstrated corticortropin-releasing hormone family (CRHs) suppressed migration of breast cancer cells via CRH...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.03.001

    authors: Jin L,Qian Y,Zhou J,Dai L,Cao C,Zhu C,Li S

    更新日期:2019-06-01 00:00:00

  • Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling.

    abstract::The ectodomain of TOLL-like receptors (TLR) is highly glycosylated with several N-linked gylcosylation sites located in the inner concave surface. The precise role of these sugar N-glycans in TLR receptor activation is unknown. Recently, we have shown that Neu1 sialidase and not Neu2, -3 and -4 forms a complex with TL...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2009.09.038

    authors: Amith SR,Jayanth P,Franchuk S,Finlay T,Seyrantepe V,Beyaert R,Pshezhetsky AV,Szewczuk MR

    更新日期:2010-02-01 00:00:00

  • xCT expression reduces the early cell cycle requirement for calcium signaling.

    abstract::Calcium has long been recognized as an important regulator of cell cycle transitions although the mechanisms are largely unknown. A functional genomic screen has identified genes involved in the regulation of early cell cycle progression by calcium. These genes when overexpressed confer the ability to bypass the G1/S ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2007.10.030

    authors: Lastro M,Kourtidis A,Farley K,Conklin DS

    更新日期:2008-02-01 00:00:00

  • Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1.

    abstract::Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is essential for the immortalization of human B cells and is linked etiologically to several human tumors. LMP1 is an integral membrane protein which acts like a constitutively active receptor. It binds tumor necrosis factor (TNF)-receptor-associated fa...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2004.03.014

    authors: Song X,Tao YG,Deng XY,Jin X,Tan YN,Tang M,Wu Q,Lee LM,Cao Y

    更新日期:2004-10-01 00:00:00

  • Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration.

    abstract::The human ether-a-go-go related gene (HERG) potassium channel has elicited intense scientific interest due to its role in cardiac repolarization and its association with arrhythmia and sudden cardiac death. Increasing evidence indicates the involvement of HERG channels in the pathophysiology of cancer. In the present ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2009.09.010

    authors: Afrasiabi E,Hietamäki M,Viitanen T,Sukumaran P,Bergelin N,Törnquist K

    更新日期:2010-01-01 00:00:00

  • Signalling via the G protein-activated K+ channels.

    abstract::The inwardly rectifying K+ channels of the GIRK (Kir3) family, members of the superfamily of inwardly rectifying K+ channels (Kir), are important physiological tools to regulate excitability in heart and brain by neurotransmitters, and the only ion channels conclusively shown to be activated by a direct interaction wi...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/s0898-6568(97)00095-8

    authors: Dascal N

    更新日期:1997-12-01 00:00:00

  • Total inhibition of phospholipase C and phosphatidylinositol 3-kinase by okadaic acid in thrombin-stimulated platelets.

    abstract::The strong inhibition of thrombin-induced platelet functions induced by okadaic acid is not correlated with the partial modification of pleckstrin phosphorylation, which remains still phosphorylated two min after stimulation, indicating that protein kinase C is not affected by okadaic acid. We then investigated the ef...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/s0898-6568(96)00119-2

    authors: Mauco G,Artçanuthurry V,Pidard D,Grelac F,Maclouf J,Lévy-Tolédano S

    更新日期:1997-01-01 00:00:00

  • Non-canonical functions of RGS proteins.

    abstract::Regulators of G protein signalling (RGS) proteins are united into a family by the presence of the RGS domain which serves as a GTPase-activating protein (GAP) for various Galpha subunits of heterotrimeric G proteins. Through this mechanism, RGS proteins regulate signalling of numerous G protein-coupled receptors. In a...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2010.03.016

    authors: Sethakorn N,Yau DM,Dulin NO

    更新日期:2010-09-01 00:00:00

  • Negative regulation of interferon-γ/STAT1 signaling through cell adhesion and cell density-dependent STAT1 dephosphorylation.

    abstract::Signal transducer and activator of transcription 1 (STAT1) is an important mediator for cytokine signal transduction, particularly IFN-γ. Following IFN-γ stimulation, STAT1 is activated through tyrosine phosphorylation. Little is known about the function and regulation of STAT1 dephosphorylation after activation. We s...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2011.04.003

    authors: Chen Z,Ma X,Zhang H,Sun X,Shen S,Li Y,Gu Y,Wang Y,Yan S,Yu Q

    更新日期:2011-08-01 00:00:00

  • Interferon alpha-armed nanoparticles trigger rapid and sustained STAT1-dependent anti-viral cellular responses.

    abstract::Interferon-α (IFNα) has enormous potential for anti-proliferative and anti-viral treatments. However, clinical success is still hampered due to its limited bioavailability and thus, lack of sustained modulation of disease-relevant protective programs. Consequently, we here examined whether IFNα immobilized on nanoscal...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2013.01.012

    authors: Pollok S,Ginter T,Günzel K,Pieper J,Henke A,Stauber RH,Reichardt W,Krämer OH

    更新日期:2013-04-01 00:00:00

  • Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of G(q/11), Gi and G(12/13) proteins in signalling by alpha1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors.

    abstract::Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS) domain of p115 RhoGEF), we investigated the contributions of G(q/11), Gi and G(12/13) proteins to G protein-coupled receptor (GPCR)-mediated activation of the extracellular signal-regulated kinase (ERK) pathway in adult rat ventric...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2004.10.008

    authors: Snabaitis AK,Muntendorf A,Wieland T,Avkiran M

    更新日期:2005-05-01 00:00:00

  • A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen.

    abstract::Binding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, in estrogen receptor-α (ERα) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras. Herein, we show that when uPAR is over-expressed, in two separate ERα-positive breast cancer cell lines, ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2012.05.011

    authors: Eastman BM,Jo M,Webb DL,Takimoto S,Gonias SL

    更新日期:2012-09-01 00:00:00

  • Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling.

    abstract::Several members of the mitogen-activated protein kinase kinase kinase (MAP3K) family including MEKK3 and TGFbeta-activating kinase (TAK1) play nonredundant roles in activation of the NF-kappaB transcription factor. However, the mechanism by which MEKK3 mediates NF-kappaB signaling is not fully understood. In this repo...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2007.12.007

    authors: Di Y,Li S,Wang L,Zhang Y,Dorf ME

    更新日期:2008-04-01 00:00:00

  • TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation.

    abstract::The nuclear factor kappa B (NF-κB) transcription factor-mediated transcription is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli. Both the proteolytic and non-proteolytic functions of ubiquitination are critically important for the regulation of NF-κB activation. L...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2010.11.017

    authors: Fan Y,Yu Y,Mao R,Zhang H,Yang J

    更新日期:2011-04-01 00:00:00

  • Activated EGF receptor may balance ERK-inhibitory network signalling pathways.

    abstract::In the COS-7 cell signalling network high levels of cAMP produced, for example, by co-stimulation of beta2-adrenergic receptor (beta2-AR) and bradykinin B2 receptor (BKR) may affect epidermal growth factor receptor (EGFR)-mediated activation of extracellular signal-stimulated kinase (ERK). In contrast, co-stimulation ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2005.08.019

    authors: Hanke S,Valkova C,Stirnweiss J,Drube S,Liebmann C

    更新日期:2006-07-01 00:00:00

  • Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.

    abstract::MAP Kinase Phosphatase-2 (MKP-2) is a dual specific nuclear phosphatase which is selective for both ERK and JNK, MAP kinases implicated in the regulation of apoptosis in response to genotoxic stress. Here we report the conditional expression of MKP-2 in human embryonic kidney cells 293. We demonstrate that Flag-WT-MKP...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2005.01.003

    authors: Cadalbert L,Sloss CM,Cameron P,Plevin R

    更新日期:2005-10-01 00:00:00

  • Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes.

    abstract::Thrombopoietin (TPO) and its receptor (c-Mpl) are the major regulators of megakaryocyte and platelet production and serve a critical and non-redundant role in hematopoietic stem cell (HSC) biology. TPO signals through the Jak-STAT, Ras-Raf-MAPK, and PI3K pathways, and promotes survival, proliferation, and polyploidiza...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2005.09.010

    authors: Chanprasert S,Geddis AE,Barroga C,Fox NE,Kaushansky K

    更新日期:2006-08-01 00:00:00

  • Frizzled7 as an emerging target for cancer therapy.

    abstract::Wnt proteins are secreted glycoproteins that bind to the N-terminal extra-cellular cysteine-rich domain of the Frizzled (Fzd) receptor family. The Fzd receptors can respond to Wnt proteins in the presence of Wnt co-receptors to activate the canonical and non-canonical Wnt pathways. Recent studies indicated that, among...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2011.12.009

    authors: King TD,Zhang W,Suto MJ,Li Y

    更新日期:2012-04-01 00:00:00

  • Emerging role of non-coding RNA in oral cancer.

    abstract::Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral squamous cell carcinoma tumorigenesis and progression remain to be elucidated. Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and extracellular RNAs (exRNAs) are emerging group...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2017.10.009

    authors: Momen-Heravi F,Bala S

    更新日期:2018-01-01 00:00:00

  • Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake.

    abstract::Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2009.01.022

    authors: Illario M,Monaco S,Cavallo AL,Esposito I,Formisano P,D'Andrea L,Cipolletta E,Trimarco B,Fenzi G,Rossi G,Vitale M

    更新日期:2009-05-01 00:00:00

  • Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A.

    abstract::Recent studies have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in cancer development and progression. However, the mechanism by which lncRNAs contribute to colorectal cancer remains unclear. In this study, we identified the lncRNA, DANCR, which was upregulated in colorectal cancer. The upregu...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109502

    authors: Lian J,Zhang H,Wei F,Li Q,Lu Y,Yu B,Yu L,Liang X,Wen Y,Jin K,Tang J,Xie W

    更新日期:2020-03-01 00:00:00

  • Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells.

    abstract::Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin. Here, we have foc...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2008.06.016

    authors: Karger A,Fitzner B,Brock P,Sparmann G,Emmrich J,Liebe S,Jaster R

    更新日期:2008-10-01 00:00:00

  • Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.

    abstract::Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and psoriatic arthritis. However, little is known on the expression patter...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2016.01.007

    authors: Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

    更新日期:2016-07-01 00:00:00

  • Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.

    abstract::Cannabinoids exert a variety of physiological and pharmacological responses in humans through interaction with specific cannabinoid receptors. Cannabinoid receptors described to date belong to the seven-transmembrane-domain receptor superfamily and are coupled through the inhibitory G(i) protein to adenylyl cyclase in...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/s0898-6568(03)00036-6

    authors: Sánchez MG,Ruiz-Llorente L,Sánchez AM,Díaz-Laviada I

    更新日期:2003-09-01 00:00:00

  • Different sensitivities of neutrophil responses to a selective protein kinase C inhibitor Ro 31-8425; redundancy in signal transduction.

    abstract::Previous studies implicating a role for protein kinase C (PKC) in mediating stimulation of cellular responses by physiological agonists have relied on use of non-specific inhibitors or direct stimulation of PKC by phorbol esters. However, much of this evidence is questionable. Here, we have investigated the effects of...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/s0898-6568(96)00097-6

    authors: Merritt JE,Sullivan JA,Tse J,Wilkinson Se,Nixon JS

    更新日期:1997-01-01 00:00:00