Biomolecular mechanisms in varicose veins development.

Abstract:

:Varicose veins (VVs) can be described as tortuous and dilated palpable veins, which are more than 3 mm in diameter. They are one of the clinical presentations of chronic venous disorders, which are a significant cause of morbidity. The prevalence of VVs has been estimated at 25-33% in women and 10-20% in men and is still increasing at an alarming rate. Family history, older age, female, pregnancy, obesity, standing occupations, and a history of deep venous thrombosis are the predominant risk factors. A great amount of factors are implicated in the pathogenesis of VVs, including changes in hydrostatic pressure, valvular incompetence, deep venous obstruction, ineffective function of calf muscle pump, biochemical and structural alterations of the vessel wall, extracellular matrix abnormalities, impaired balance between growth factors or cytokines, genetic alterations, and several other mechanisms. Nevertheless, the issue of pathogenesis in VVs is still not completely known, even if a great progress has been made in understanding their molecular basis. This kind of studies appears promising and should be encouraged, and perhaps the new insight in this matter may result in targeted therapy or possibly prevention.

journal_name

Ann Vasc Surg

authors

Segiet OA,Brzozowa-Zasada M,Piecuch A,Dudek D,Reichman-Warmusz E,Wojnicz R

doi

10.1016/j.avsg.2014.10.009

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

377-84

issue

2

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(14)00596-2

journal_volume

29

pub_type

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