Abstract:
:Candidate gene studies have yet to investigate the glutamate system, the primary excitatory neurotransmitter of the HPA-axis related to PTSD risk. We investigated 13 SNPs in the glutamate transporter gene (SLC1A1) in relation to PTSD among combat-exposed veterans. Participants (n=418) completed a diagnostic interview and provided a blood sample for DNA isolation and genotyping. A subset of participants (n=391) had severity and combat exposure data available. In the primary logistic regression gender and rs10739062 were significant predictors of PTSD diagnosis (OR=0.50; OR=1.43). In the linear regression analysis, combat exposure was the only significant predictor (β=0.16) of severity. A computed genetic risk sum score was significant in relation to PTSD diagnosis (OR=1.15) and severity scores (β=0.14) above and beyond the effects of combat exposure. This study provides preliminary support for the relationship of glutamate transporter polymorphisms to PTSD risk and the need for further genetic studies within this system.
journal_name
J Anxiety Disordjournal_title
Journal of anxiety disordersauthors
Zhang J,Sheerin C,Mandel H,Banducci AN,Myrick H,Acierno R,Amstadter AB,Wang Zdoi
10.1016/j.janxdis.2014.09.013subject
Has Abstractpub_date
2014-12-01 00:00:00pages
902-7issue
8eissn
0887-6185issn
1873-7897pii
S0887-6185(14)00137-6journal_volume
28pub_type
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journal_title:Journal of anxiety disorders
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journal_title:Journal of anxiety disorders
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journal_title:Journal of anxiety disorders
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doi:10.1016/s0887-6185(99)00002-x
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journal_title:Journal of anxiety disorders
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journal_title:Journal of anxiety disorders
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/s0887-6185(00)00048-7
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journal_title:Journal of anxiety disorders
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doi:10.1016/j.janxdis.2011.01.001
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.janxdis.2006.03.011
更新日期:2007-01-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章,多中心研究
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2007.03.010
更新日期:2008-01-01 00:00:00
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更新日期:2019-10-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2009.08.005
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Although generalized anxiety disorder (GAD) is characterized by multiple worries, anxiety about one's health is absent in the DSM-IV description of the illness. METHOD:A random community-based telephone survey (N = 2005) that covered DSM-IV symptoms of GAD, two core symptoms of major depression, Rome-III cr...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2010.10.012
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journal_title:Journal of anxiety disorders
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journal_title:Journal of anxiety disorders
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journal_title:Journal of anxiety disorders
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doi:10.1016/j.janxdis.2005.02.005
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2009.10.001
更新日期:2010-01-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2011.11.012
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2011.04.004
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2016.03.003
更新日期:2016-06-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2020.102209
更新日期:2020-04-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章,评审
doi:10.1016/j.janxdis.2018.01.005
更新日期:2018-03-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/j.janxdis.2017.09.007
更新日期:2017-12-01 00:00:00
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journal_title:Journal of anxiety disorders
pub_type: 杂志文章
doi:10.1016/s0887-6185(02)00223-2
更新日期:2003-01-01 00:00:00
abstract::Consistent with a risk reduction model of targeted prevention, the present investigation piloted and empirically evaluated the feasibility and short-term efficacy of a first-generation panic prevention program that targeted two malleable risk factors for panic development-anxiety sensitivity and daily cigarette smokin...
journal_title:Journal of anxiety disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.janxdis.2008.01.005
更新日期:2008-10-01 00:00:00