Abstract：
:The effects of caffeine (1-100 mg/kg, IP), (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA) (0.01-1 mg/kg, IP), and of the two drugs in combination were studied in mice responding under a mult FR30 FI600 s schedule of food presentation. The lowest dose of caffeine, 1 mg/kg, had no effect on responding under either component of the mult schedule. Intermediate doses of caffeine (3 and 10 mg/kg) slightly increased responding under the FI component, while higher doses decreased responding. Caffeine only decreased responding, at doses above 30 mg/kg, under the FR component. PIA decreased responding under both components of the mult schedule in a dose-dependent, and similar, manner. In most cases, the rate-increasing effect of caffeine on FI responding was diminished when combined with a rate-decreasing dose of PIA. However, when 0.01 mg/kg PIA, a dose that had no effect alone, was combined with 3 mg/kg caffeine, the increase in rate exceeded that of caffeine alone. Rate-decreasing effects of PIA were antagonized by caffeine; with larger doses of PIA, larger doses of caffeine were required for antagonism. Thus, while the rate-increasing effects of caffeine can be either enhanced or diminished, when combined with different doses of PIA, the rate-decreasing effects of PIA are clearly antagonized by caffeine in a dose-dependent manner.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Glowa JR,Sobel E,Malaspina S,Dews PBdoi
10.1007/BF00432506subject
Has Abstractpub_date
1985-01-01 00:00:00pages
421-4issue
4eissn
0033-3158issn
1432-2072journal_volume
87pub_type
杂志文章abstract：:The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00518186
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-017-4622-9
更新日期：2017-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00634469
更新日期：1989-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246641
更新日期：1996-02-01 00:00:00
abstract：:The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427882
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1814-x
更新日期：2004-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00428027
更新日期：1978-09-15 00:00:00
abstract：RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0359-6
更新日期：2006-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100686
更新日期：2001-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02311180
更新日期：1995-08-01 00:00:00
abstract：RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100700
更新日期：2001-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1106-2
更新日期：2002-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245224
更新日期：1994-01-01 00:00:00
abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2527-6
更新日期：2012-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00571418
更新日期：1978-01-31 00:00:00
abstract：RATIONALE:Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:The present experime...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3285-4
更新日期：2014-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244213
更新日期：1991-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02244860
更新日期：1994-03-01 00:00:00
abstract：RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-013-3423-z
更新日期：2014-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432172
更新日期：1981-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427282
更新日期：1976-09-17 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3658-3
更新日期：2015-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247394
更新日期：1996-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3610-6
更新日期：2014-12-01 00:00:00
abstract：:To test the Pavlovian conditioning model of alcohol tolerance, two groups of eight male social drinkers each received five administrations of alcohol and five administrations of an equal volume of tonic each, on an alternating basis, during the initial 10-session tolerance development phase of the study. Group 1 recei...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310519
更新日期：1986-01-01 00:00:00
abstract：:The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 microgram...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00470593
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Adolescence marks a period of increased vulnerability to the development of substance use disorders. High sweet preference is a genetically mediated behavioral trait that also predicts vulnerability to substances of abuse. Previous research has shown that while adolescent rats selectively bred for high (HiS) ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2958-8
更新日期：2013-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426811
更新日期：1979-03-14 00:00:00
abstract：:Active uptake of serotonin by blood platelets of acute schizophrenic patients has been compared to that of a control group. Preliminary results presented in this article indicate that the uptake of the schizophrenic patients was about 40% lower than that of controls. Patients were followed over a period of 5 weeks wit...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00496061
更新日期：1979-08-08 00:00:00
abstract：INTRODUCTION:Genetic causes, or predisposition, are increasingly accepted to be part of the ethiopathogenesis of many neuropsychiatric diseases. While genes can be studied in any type of cells, their physiological function in human brain cells is difficult to evaluate, particularly in living subjects. METHODS:As a fir...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3384-2
更新日期：2014-03-01 00:00:00
