当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > The adverse effect profile of oral azathioprine in pediatric atopic dermatitis, and recommendations for monitoring.

The adverse effect profile of oral azathioprine in pediatric atopic dermatitis, and recommendations for monitoring.

Abstract：

BACKGROUND:Azathioprine is efficacious in the treatment of severe childhood atopic dermatitis; however, robust data on adverse effects in this population are lacking. OBJECTIVE:We sought to assess adverse effects of azathioprine treatment in a pediatric atopic dermatitis cohort, and make recommendations for monitoring based on these data. METHODS:Blood test results for all 82 children prescribed oral azathioprine for atopic dermatitis in our department between 2010 and 2012 were collated prospectively, and clinical notes were reviewed retrospectively. RESULTS:Mean age at commencing azathioprine was 8.3 years (SEM 0.4). Mean maximum doses were 2.4 mg/kg (SEM 0.1) and 1.5 mg/kg (SEM 0.1) for normal and reduced serum thiopurine-S-methyltransferase levels, respectively. Adverse effects on blood indices occurred in 34 of 82 patients (41%), with pronounced effects in 18 of 82 (22%) after a median time of 0.4 years. Two patients stopped therapy as a result of abnormal blood indices. Clinical adverse effects occurred in 16 of 82 (20%), two resulting in cessation of therapy. Incidence of adverse effects was unaffected by age, sex, thiopurine-S-methyltransferase level, and drug dose on multivariate regression. LIMITATIONS:Comparison with other studies is limited by varying definitions of adverse effects. CONCLUSION:Oral azathioprine was associated with few pronounced adverse effects for the duration of use and dosage in this cohort. Recommendations for monitoring are made.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Fuggle NR,Bragoli W,Mahto A,Glover M,Martinez AE,Kinsler VA

doi

10.1016/j.jaad.2014.08.048

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

108-14

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(14)01905-7

journal_volume

72

pub_type

杂志文章

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