The C-terminal domain of eukaryotic acidic ribosomal P2 proteins is intrinsically disordered with conserved structural propensities.

abstract：:Sry-related box (Sox) transcription factors share a conserved high-mobility-group box domain (HMG-domain) that binds DNA in the minor groove and bends DNA for further assembly of transcriptional machineries. During organogenesis, each member of the Sox family triggers a specific cell lineage differentiation, indicatin...

journal_title：Protein and peptide letters

authors： Gao N,Jiang W,Gao H,Cheng Z,Qian H,Si S,Xie Y

更新日期：2013-04-01 00:00:00

abstract：:Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, a...

journal_title：Protein and peptide letters

authors： Yu DY,Qiao N,Liu P,Wei Q

更新日期：2009-01-01 00:00:00

abstract：:Prediction of protein structure from its amino acid sequence is still a challenging problem. The complete physicochemical understanding of protein folding is essential for the accurate structure prediction. Knowledge of residue solvent accessibility gives useful insights into protein structure prediction and function ...

journal_title：Protein and peptide letters

authors： Pugalenthi G,Kandaswamy KK,Chou KC,Vivekanandan S,Kolatkar P

更新日期：2012-01-01 00:00:00

abstract：:In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad...

journal_title：Protein and peptide letters

authors： Albiston AL,Ye S,Chai SY

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Cryptochrome is a flavin-binding blue-light photoreceptor that functions in growth and development in plants, the circadian clock in animals and navigation in birds. However, a lack of purified cryptochrome has hindered studies of the structure and function of this protein. In this study, we obtained a subst...

journal_title：Protein and peptide letters

authors： Yuan X,Wang W,Wu W,Wang J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Searching the biomarker from complex heterogeneous material for early detection of disease is a challenging task in the field of biomedical sciences. OBJECTIVE:The study has been arranged to explore the proteomics serum derived profiling of the differential expressed and low molecular weight protein in brea...

journal_title：Protein and peptide letters

authors： Zafar A,Jabbar M,Manzoor Y,Gulzar H,Hassan SG,Nazir MA,Ain-Ul-Haq,Mustafa G,Sahar R,Masood A,Iqbal A,Hussain M,Hasan M

更新日期：2020-01-01 00:00:00

abstract：:Quantum mechanical fragment molecular orbital calculations have been performed for receptor binding of the hemagglutinin protein of the recently pandemic influenza 2009 H1N1, A/swine/Iowa/1930, and A/Puerto Rico/8/1934 viruses to α2-6 linked sialyloligosaccharides, as analogs of human receptors. The strongest receptor...

journal_title：Protein and peptide letters

authors： Fukuzawa K,Omagari K,Nakajima K,Nobusawa E,Tanaka S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Nanosheets of SnO2 which an n-type semiconductor with a rutile-type crystalline structure are predominantly used as gas sensors. SnO2 nanosheets have a tetragonal crystal structure where growth along the c-axis is suppressed to form a sheet. The major exposed facets of SnO2 nanosheets have {110}, {101} and {...

journal_title：Protein and peptide letters

authors： Nakazawa H,Seta Y,Hirose T,Masuda Y,Umetsu M

更新日期：2018-01-01 00:00:00

abstract：:Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the ...

journal_title：Protein and peptide letters

authors： Gonçalves DC,Gava LM,Ramos CH

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass f...

journal_title：Protein and peptide letters

authors： Khan AZ,Shahid A,Cheng H,Mahboob S,Al-Ghanim KA,Bilal M,Liang F,Nawaz MZ

更新日期：2018-01-01 00:00:00

abstract：:Chemical probing of histidine residues using specific modifiers, iodoacetic acid (IAA) and diethylpyrocarbonate (DEP) resulted in the inactivation of phytase (phy A). The kinetic theory of the substrate reaction during the modification of enzyme activity was applied to a study of the kinetics of the course of inactiva...

journal_title：Protein and peptide letters

authors： Wang XY,Sun ML,Zhao DM,Wang M

更新日期：2006-01-01 00:00:00

abstract：:We have studied the effect of guanidinium chloride (Gdn.Cl) and different osmolytes such as betaine, trimethylamine-N-oxide (TMAO) and urea on the rate of chymotrypsin catalyzed reaction. The rates were measured using three synthetic chromogenic substrates, succinyl-ala-ala-pro-arg-pNA (AAPR), succinyl-ala-ala-pro-leu...

journal_title：Protein and peptide letters

authors： Garringer M,Qasim MA

更新日期：2016-01-01 00:00:00

abstract：:Allergy prevalence has increased worldwide over the last 25 years along with industrialization and westernized lifestyles. Indoor allergens are primarily responsible for the sensitization and development of atopic diseases. The main indoor allergens are known to be derived from various arthropods which account for up ...

journal_title：Protein and peptide letters

authors： Jeong KY,Hong CS,Yong TS

更新日期：2007-01-01 00:00:00

abstract：:Identifying protein complexes in protein-protein interaction (PPI) networks is a fundamental problem in computational biology. High-throughput experimental techniques have generated large, experimentally detected PPI datasets. These interactions represent a rich source of data that can be used to detect protein comple...

journal_title：Protein and peptide letters

authors： Liao B,Fu X,Cai L,Chen H

更新日期：2014-07-01 00:00:00

abstract：:Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in ce...

journal_title：Protein and peptide letters

authors： Wang X,Wang D,Zhao J,Qu M,Zhou X,He H,He R

更新日期：2006-01-01 00:00:00

abstract：:Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of...

journal_title：Protein and peptide letters

authors： Conlon JM,Al-Ghaferi N,Abraham B,Sonnevend A,King JD,Nielsen PF

更新日期：2006-01-01 00:00:00

abstract：:Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molec...

journal_title：Protein and peptide letters

authors： Agueci F,Polticelli F,Sinibaldi F,Piro MC,Santucci R,Fiorucci L

更新日期：2007-01-01 00:00:00

abstract：:Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and r...

journal_title：Protein and peptide letters

authors： Hirano K,Aya K,Matsuoka M,Ueguchi-Tanaka M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Assisted Reproduction Techniques (ART) have significantly advanced since the first successful In Vitro Fertilization (IVF). However, most in vitro-produced embryos fail to implant. Key steps in ART are the correct infertility diagnosis, in order to manage the individualised treatments, and the assessment of ...

journal_title：Protein and peptide letters

authors： De Rose MB,Piccolomini MM,Soares Belo AS,Borges E Jr,Filho FF

更新日期：2018-01-01 00:00:00

abstract：:This study revealed that the content of protein S29 in ribosomes of cancer cell line A549 was distinctly low (equivalent to about 30% of that of 2BS). The conclusion was acquired based on the ratios of spot volume of ribosomal protein S29 to that of several other ribosomal proteins (S29/L37a, S29/L38, S29/S27 and S29/...

journal_title：Protein and peptide letters

authors： Zhou ZD,Bao L,Liu DG,Li MQ,Ge YZ,Huang YL,Liu WY

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten...

journal_title：Protein and peptide letters

authors： Climacosa FMM,King RAN,Santos BMM,Caoili SEC

更新日期：2020-01-01 00:00:00

abstract：:Phage Virion Proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. Accurate identification of phage virion proteins is helpful to understand the mechanism of interaction between the phage and its host bacteria. Since experimental method is labor intensive and t...

journal_title：Protein and peptide letters

authors： Chen W,Nie F,Ding H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Haloalkane dehalogenases (EC 3.8.1.5, HLDs) are α/β-hydrolases which catalyze the irreversible cleavage of carbon-halogen bonds of haloalkanes, producing an alcohol, a halide and a hydrogen ion. Haloalkanes are acutely toxic to animals and humans and their toxic effects are mainly observed in the liver, kidn...

journal_title：Protein and peptide letters

authors： Georgakis N,Chronopoulou E,Gad MA,Skliros D,Efrose R,Flemetakis E,Labrou NE

更新日期：2017-01-01 00:00:00

abstract：:We present two efficient network propagation algorithms that operate on a binary tree, i.e., a sparse-edged substitute of an entire similarity network. TreeProp-N is based on passing increments between nodes while TreeProp-E employs propagation to the edges of the tree. Both algorithms improve protein classification e...

journal_title：Protein and peptide letters

authors： Kocsor A,Busa-Fekete R,Pongor S

更新日期：2008-01-01 00:00:00

abstract：:Comparison between the BAD complexes indicated that BAD all docks a hydrophobic surface of PKAc regardless of its phosphorylation. PKAc may prevent Bcl-xL from rebinding to BAD by phosphorylating human BAD at Ser118; whereas human BAD is phosphorylated on Ser75 in a BAD-Bcl-xL complex, resulting in the dissociation of...

journal_title：Protein and peptide letters

authors： Yang J

更新日期：2010-02-01 00:00:00

abstract：:Free radicals induce protein modifications, often associated to many biological phenomena. This mini-review overviews the approaches we have used to elucidate the radical-induced damages on sulfur-containing enzymes, such as ribonuclease and lysozyme, and the possible post-translational mechanism of the damage to anot...

journal_title：Protein and peptide letters

authors： Torreggiani A,Tamba M,Ferreri C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Laminin, a member of the Extracellular Matrix (ECM), is a glycoprotein that is used as a factor that affects cell adhesion, proliferation, survival, and differentiation. Of these, five globular domains (LG domains) of the alpha chain play an important role in influencing the cell by binding to the integrin. ...

journal_title：Protein and peptide letters

authors： Kim JE,Seo HJ,Lee S,Jang JH

更新日期：2019-01-01 00:00:00

abstract：:The small heat shock protein SsHSP14.1 from the hyper-thermophilic archeaon, Sulfolobus solfataricus (S. solfataricus) was able to protect proteins from thermal aggregation and prevent enzymes from heat induced inactivation. According to the 3D (dimensional) structural model of SsHSP14.1 developed by us before, the re...

journal_title：Protein and peptide letters

authors： Wen ZZ,Wang YH,Yang B,Xie MQ,Chou KC

更新日期：2011-03-01 00:00:00

abstract：:The mutation, conferring streptomycin and deoxyglucose resistance on cells, had profound effect on the kinetic and thermodynamic parameters inferring thermostabilization of beta-glucosidase from mutant 51 SM(r) of Cellulomonas biazotea. Free energy of activation for substrate binding, enthalpy and entropy of activatio...

journal_title：Protein and peptide letters

authors： Rajoka MI,Durrani IS,Khalid AM

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...

journal_title：Protein and peptide letters

authors： Francisco CC,Luis CJ,Marina EJ,Javier CF,Alexis LA,Del Carmen SH,Alfredo RI

更新日期：2019-01-01 00:00:00