当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF LEGAL MEDICINE期刊下所有文献 > Genetic and toxicologic investigation of Sudden Cardiac Death in a patient with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) under cocaine and alcohol effects.

Genetic and toxicologic investigation of Sudden Cardiac Death in a patient with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) under cocaine and alcohol effects.

Abstract：

:Cocaine and alcohol toxicity is well known, especially when simultaneously abused. These drugs perform both acute and chronic harmfulness, with significant cardiac events such as ventricular arrhythmias, tachycardia, systemic hypertension, acute myocardial infarction, ventricular hypertrophy, and acute coronary syndrome. The present report refers about a patient who died after a documented episode of psychomotor agitation followed by cardiac arrest. At the autopsy investigation, arrhythmogenic right ventricular cardiomyopathy (ARVC) was diagnosed and confirmed by postmortem molecular analysis revealing a mutation in the DSG2 gene. Postmortem toxicological analysis demonstrated a recent intake of cocaine, and the death was attributed to cardiac arrhythmias. The detection of cocaine and cocaethylene in hair samples proved chronic simultaneous intake of cocaine and alcohol at least in the last month. The authors discuss the role of these drugs and genetic predisposition of the ARVC in causing the death of the patient.

journal_name

Int J Legal Med

journal_title

International journal of legal medicine

authors

Cittadini F,De Giovanni N,Alcalde M,Partemi S,Carbone A,Campuzano O,Brugada R,Oliva A

doi

10.1007/s00414-014-1119-5

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

89-96

issue

1

eissn

0937-9827

issn

1437-1596

journal_volume

129

pub_type

杂志文章

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