Effects of hemorrhagic shock on nuclear DNA.

Abstract:

:Rats, with their liver DNA labeled with 3H-thymidine, were subjected to hemorrhagic shock. In nine rats reversible hemorrhagic shock with a blood pressure of 40 mm Hg for 30 minutes resulted in no breaks in the DNA. Twenty-seven animals were subjected to severe hemorrhagic shock. Blood pressures of 40 mm Hg were maintained in the 27 animals until 50% of the shed blood was infused in 11 animals and until 70% of the shed blood was reinfused in 16 animals. This degree of hemorrhage resulted in the DNA being broken, so that 45.1% and 52.1% of the DNA was of a small molecular weight species, as compared with 9.5% and 10.8% in the preshocked animals (P less than 0.001). The injured DNA was not repaired 1.5 hours after the animals were resuscitated in the animals subjected to severe hemorrhagic shock.

journal_name

Surgery

journal_title

Surgery

authors

Lazarus HM,Hopfenbeck A

subject

Has Abstract

pub_date

1979-03-01 00:00:00

pages

297-302

issue

3

eissn

0039-6060

issn

1532-7361

pii

0039-6060(79)90104-1

journal_volume

85

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Extended versus conventional thromboprophylaxis after major abdominal and pelvic surgery: Systematic review and meta-analysis of randomized clinical trials.

    abstract:BACKGROUND:Venous thromboembolism, presenting as deep vein thrombosis or pulmonary embolism, can be associated with considerable morbidity after major abdominal and pelvic surgery. Perioperative thromboprophylaxis with low-molecular-weight heparin is well established, but the duration of treatment remains debated. We a...

    journal_title:Surgery

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.surg.2018.05.028

    authors: Rausa E,Kelly ME,Asti E,Aiolfi A,Bonitta G,Winter DC,Bonavina L

    更新日期:2018-12-01 00:00:00

  • Radiofrequency ablation for large hepatic hemangiomas: initial experience and lessons.

    abstract:OBJECTIVE:We aimed to assess the feasibility, safety, and efficacy of radiofrequency (RF) ablation for the treatment of large (≥5 cm in greatest diameter) hepatic hemangiomas. METHODS:Thirty-six patients (15 male, 21 female; mean age 50 years) with 41 hepatic hemangiomas ≥5 cm in diameter were enrolled and treated wit...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2012.06.004

    authors: Gao J,Ke S,Ding XM,Zhou YM,Qian XJ,Sun WB

    更新日期:2013-01-01 00:00:00

  • Endothelial cell seeding of small-caliber synthetic grafts in the baboon.

    abstract::Endothelial cell (EC) seeding has been proposed as a method to improve the performance of small-caliber synthetic vascular prostheses. Seeding experiments to date have all been carried out in the dog. This study investigates EC seeding of small-caliber Dacron carotid interposition grafts compared with contralateral co...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Shepard AD,Eldrup-Jorgensen J,Keough EM,Foxall TF,Ramberg K,Connolly RJ,Mackey WC,Gavris V,Auger KR,Libby P

    更新日期:1986-03-01 00:00:00

  • Medicare inpatient and 90-day postdischarge adverse outcomes in carotid artery surgery.

    abstract:BACKGROUND:Longitudinal, risk-adjusted measurement of outcomes of carotid artery (CA) surgery is necessary for the evaluation of quality performance and for the assessment of strategies of quality improvement. METHODS:Patients from quality coding hospitals who underwent CA surgery and met procedural and diagnostic cod...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.06.005

    authors: Fry DE,Pine M,Locke D,Reband A,Torres Z,Pine G

    更新日期:2015-10-01 00:00:00

  • Hyperparathyroid crisis and posterior mediastinal parathyroid adenoma: a case for preoperative localization.

    abstract::Hyperparathyroid crisis is a rare, life-threatening condition that requires prompt removal of the involved parathyroid gland(s). This report describes a patient with hyperparathyroid crisis caused by a mediastinal parathyroid adenoma, which was localized before operation and removed at the initial operation, without n...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Pezzi CM,Sirico-Kelly F,Maxwell RJ,Corrigan DF

    更新日期:1993-05-01 00:00:00

  • Analysis of errors enacted by surgical trainees during skills training courses.

    abstract:BACKGROUND:Despite the emphasis on medical error as a major cause of hospital morbidity and mortality, there has been little published work on errors committed by trainees. This issue is particularly relevant to the training of surgeons and was addressed by our study. METHODS:Sixty simulated laparoscopic cholecystecto...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2005.02.014

    authors: Tang B,Hanna GB,Cuschieri A

    更新日期:2005-07-01 00:00:00

  • The current role of parathyroid cryopreservation and autotransplantation in parathyroid surgery: an institutional experience.

    abstract:BACKGROUND:Hypoparathyroidism after cervical exploration is a rare but problematic complication. Cryopreservation and subsequent autotransplantation of parathyroid tissue are infrequently used to combat this problem; effective usage of this surgical adjunct remains variable. METHODS:From 1981 through 1995 we performed...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(97)90209-9

    authors: Caccitolo JA,Farley DR,van Heerden JA,Grant CS,Thompson GB,Sterioff S

    更新日期:1997-12-01 00:00:00

  • Primary hepatic malignancy: surgical management and determinants of survival.

    abstract::To further define the clinicopathologic features and determinants of survival, we reviewed the cases of 110 patients with primary hepatic malignancy managed surgically between 1975 and 1986. Presenting signs of symptoms were pain (57%), fatigue (48%), abdominal mass (40%), and weight loss (33%). Twenty-six percent of ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Nagorney DM,van Heerden JA,Ilstrup DM,Adson MA

    更新日期:1989-10-01 00:00:00

  • Intraoperative sestamibi scanning in reoperative parathyroidectomy.

    abstract:BACKGROUND:Reoperative neck exploration for hyperparathyroidism is often difficult even for experienced surgeons. Recent advances in preoperative and intraoperative localization techniques have improved successful resection rates. This prospective study evaluates the accuracy and clinical utility of intraoperative tech...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章

    doi:10.1067/msy.2000.109533

    authors: Rossi HL,Ali A,Prinz RA

    更新日期:2000-10-01 00:00:00

  • A statewide consortium of surgical care: a longitudinal investigation of vascular operative procedures at 16 hospitals.

    abstract:BACKGROUND:Regional surgical quality improvement consortiums are becoming more common. Herein we have reported the effectiveness of a statewide consortium focusing on open vascular operative procedures. METHODS:The statewide Michigan Surgical Quality Consortium was established in 2005 with 16 hospitals that report cas...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2010.07.009

    authors: Henke PK,Kubus J,Englesbe MJ,Harbaugh C,Campbell DA

    更新日期:2010-10-01 00:00:00

  • Influence of trauma system implementation on process of care delivered to seriously injured patients in rural trauma centers.

    abstract:BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...

    journal_title:Surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1067/msy.2001.115898

    authors: Olson CJ,Arthur M,Mullins RJ,Rowland D,Hedges JR,Mann NC

    更新日期:2001-08-01 00:00:00

  • Bax deficiency rescues resection-induced enterocyte apoptosis in mice with perturbed EGF receptor function.

    abstract:BACKGROUND:Adaptation after massive smallbowel resection (SBR) is associated with increased cell turnover, increased rates of enterocyte proliferation, and apoptosis. Epidermal growth factor receptor (EGFR) inhibition attenuates adaptation and increases apoptosis. Intestinal levels of bax appear to correlate with EGFR ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2004.04.004

    authors: Jarboe MD,Juno RJ,Bernal NP,Knott AW,Zhang Y,Erwin CR,Warner BW

    更新日期:2004-08-01 00:00:00

  • Reversal of ischemic damage with amino acid substrate enhancement during reperfusion.

    abstract::Twenty dogs underwent 15 minutes of normothermic ischemic arrest and 30 minutes of reperfusion while on cardiopulmonary bypass. In 10 control dogs, the reperfusate blood was not modified. In 10 other dogs, the aorta was reclamped and the heart reperfused for 5 minutes with blood containing L-glutamate (0.026M). We mea...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Lazar HL,Buckberg GD,Manganaro AJ,Becker H,Maloney JV Jr

    更新日期:1980-11-01 00:00:00

  • Gastroduodenal arterial aneurysms: report of a case and review of the literature.

    abstract::Aneurysms of the gastroduodenal artery are rare. Only nine cases have been reported previously. These aneurysms are extremely difficult to diagnose preoperatively. A case of ruptured gastroduodenal artery aneurysm, which was diagnosed by aortography prior to operation, is reported, and the literature is reviewed. ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Sethi GK,Nelson RM

    更新日期:1976-02-01 00:00:00

  • Internal pancreatic fistula to the pericardium and pleura.

    abstract::A report of a 38-year-old man with a 10 month course of illness characterized by recurrent pericardial and pleural high-protein, high-amylase effusions is presented. Operative pancreatogram demonstrated fistulization from the mid-pancreas through the mediastinum into both pleural spaces and the pericardium. Surgical d...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Davidson ED,Horney JT,Salter PP 3rd

    更新日期:1979-04-01 00:00:00

  • The surgical treatment of superficial thrombophlebitis.

    abstract::Of 3,941 patients who underwent varicose vein surgery from 1968 through 1978, 163 had superficial thrombophlebitis, a common complication of varicose veins. Superficial thrombophlebitis was more frequently found in the older age groups. The incidence of occurrence (three women to one man) was identical to that of the ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Lofgren EP,Lofgren KA

    更新日期:1981-07-01 00:00:00

  • Early mortality after liver transplantation: Defining the course and the cause.

    abstract:BACKGROUND:The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. METHODS:Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Orga...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2018.04.039

    authors: Baganate F,Beal EW,Tumin D,Azoulay D,Mumtaz K,Black SM,Washburn K,Pawlik TM

    更新日期:2018-10-01 00:00:00

  • Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas.

    abstract:BACKGROUND:The efficacy of octreotide in the regulation of endocrine tumor secretion and symptomatology has been well documented. Its effects on neuroendocrine tumor generation and cell proliferation are less well understood. The purpose of this study was to determine if blockade of somatostatin receptors by octreotide...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Modlin IM,Kumar R,Nangia A,Soroka CJ,Pasikhov D,Goldenring JR

    更新日期:1992-12-01 00:00:00

  • Cadaveric renal transplantation in the cyclosporine and OKT3 eras.

    abstract::With advances in clinical immunosuppression, results in organ transplantation continue to improve. During a 52-month period, 507 cadaver renal transplants were performed, including 435 primary and 72 nonprimary transplants. All patients were managed with quadruple immunosuppression (prednisone, azathioprine, sequentia...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Stratta RJ,D'Alessandro AM,Hoffmann RM,Sollinger HW,Kalayoglu M,Lorentzen DF,Pirsch JD,Belzer FO

    更新日期:1988-10-01 00:00:00

  • Nonoperative management of blunt hepatic trauma in adults.

    abstract::Although well accepted in pediatric patients, nonoperative management of blunt hepatic trauma in adults remains controversial. From January 1981 through May 1987, 66 adults were identified with blunt hepatic trauma that had been confirmed by abdominal exploration or abdominal computed tomography (CT): 46 underwent imm...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Farnell MB,Spencer MP,Thompson E,Williams HJ Jr,Mucha P Jr,Ilstrup DM

    更新日期:1988-10-01 00:00:00

  • Portoatrial shunt in Budd-Chiari syndrome.

    abstract::It is now well accepted that mesoatrial bypass is an efficient treatment of Budd-Chiari syndrome and that it is indicated when the inferior vena cava is obstructed. This report presents a patient in whom the superior mesenteric vein was thrombosed after a previous mesocaval shunt. A bypass was constructed between the ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Franco D,Vons C,Lecompte Y,Nuzzo G,Smadja C

    更新日期:1986-03-01 00:00:00

  • Hyperparathyroidism and gastroenteropancreatic hormone levels.

    abstract::The diagnosis of multiple endocrine neoplasia (MEN) in patients with presumed hyperparathyroidism has important ramifications for patient management especially since as many as 20% of patients with hyperparathyroidism may have associated MEN. Gut hormone levels were measured before and after surgery in 28 patients who...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Strodel WE,Vinik AI,Eckhauser FE,Thompson NW

    更新日期:1985-12-01 00:00:00

  • Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.

    abstract:BACKGROUND:Propranolol has been shown previously to restore bone marrow function and improve anemia after lung contusion/hemorrhagic shock. We hypothesized that daily clonidine administration would inhibit central sympathetic outflow and restore bone marrow function in our rodent model of lung contusion/hemorrhagic sho...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2016.08.043

    authors: Alamo IG,Kannan KB,Ramos H,Loftus TJ,Efron PA,Mohr AM

    更新日期:2017-03-01 00:00:00

  • Changes in the levels of endogenous antioxidants in the liver of mice with experimental endotoxemia and the protective effects of the antioxidants.

    abstract::Gram-negative bacterial endotoxin (lipopolysaccharide) induces hepatic damage in mice caused by lipid peroxidation, and administration of antioxidants (coenzyme Q10 and alpha-tocopherol) suppresses this lipid peroxidation, preserves energy metabolism, and enhances the survival of endotoxin-administered mice. Therefore...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Sugino K,Dohi K,Yamada K,Kawasaki T

    更新日期:1989-02-01 00:00:00

  • Pilot study of a population-based survey to assess the prevalence of surgical conditions in Uganda.

    abstract:BACKGROUND:Noncommunicable diseases, including those requiring surgical care, are increasingly straining low- and middle-income countries. Globally, 11% of all disability-adjusted life-years lost result from conditions requiring surgery; however, little is known about country-specific burden. We piloted a household-bas...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2015.05.011

    authors: Butler EK,Tran TM,Fuller AT,Makumbi F,Luboga S,Kisakye S,Haglund MM,Chipman JG,Galukande M

    更新日期:2015-09-01 00:00:00

  • Kinetic analysis of the rapid intraoperative parathyroid hormone assay in patients during operation for hyperparathyroidism.

    abstract:BACKGROUND:Rapid intraoperative parathyroid hormone (RI-PTH) assay is used to guide adequacy of resection during operation for hyperparathyroidism. We compared the RI-PTH assay (15 minutes) with a standard PTH assay, determined whether the PTH half-life varied between patients, and constructed a kinetic analysis of the...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2099.101835

    authors: Libutti SK,Alexander HR,Bartlett DL,Sampson ML,Ruddel ME,Skarulis M,Marx SJ,Spiegel AM,Simmonds W,Remaley AT

    更新日期:1999-12-01 00:00:00

  • Independent preclerkship study: a five year experience.

    abstract::An independent study program (ISP) was instituted in 1970 for a group of 32 preclerkship medical students picked randomly from a group of 64 volunteers. The academic achievements of these classes, as measured by mean National Board scores, is compared with their classmates in the lecture discussion (LD) program where ...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Williams TE Jr,Meleca CB,Merola AJ,Camiscioni JS,Kilman JW

    更新日期:1977-06-01 00:00:00

  • Reverse electrical pacing improves intestinal absorption and transit time.

    abstract::This study evaluates the effect of reverse electrical pacing on intestinal absorption and transit time in an enterostomy model. Twenty-five male Sprague-Dawley rats (148 to 208 gm) underwent division and anastomosis of the proximal jejunum to eliminate the proximal gastroduodenal pacemaker. A 30.0 cm loop ileostomy wa...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Sawchuk A,Nogami W,Goto S,Yount J,Grosfeld JA,Lohmuller J,Grosfeld MD,Grosfeld JL

    更新日期:1986-08-01 00:00:00

  • Impact of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) on growth of colorectal liver metastases.

    abstract:BACKGROUND:Associating liver partition and portal vein ligation for staged hepatectomy induces an unprecedented liver hypertrophy and enables resection of otherwise unresectable liver tumors. The effect of associating liver partition and portal vein ligation for staged hepatectomy on tumor proliferation, however, remai...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2017.10.036

    authors: Kambakamba P,Linecker M,Schneider M,Reiner CS,Nguyen-Kim TDL,Limani P,Romic I,Figueras J,Petrowsky H,Clavien PA,Lesurtel M

    更新日期:2018-02-01 00:00:00

  • Hypoxia of the growing liver accelerates regeneration.

    abstract:BACKGROUND:After portal vein ligation of 1 side of the liver, the other side regenerates at a slow rate. This slow growth may be accelerated to rapid growth by adding a transection between the 2 sides, i.e., performing portal vein ligation and parenchymal transection. We found that in patients undergoing portal vein li...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2016.05.018

    authors: Schadde E,Tsatsaris C,Swiderska-Syn M,Breitenstein S,Urner M,Schimmer R,Booy C,Z'graggen BR,Wenger RH,Spahn DR,Hertl M,Knechtle S,Diehl AM,Schläpfer M,Beck-Schimmer B

    更新日期:2017-03-01 00:00:00