Amniotic fluid microviscosity determined by fluorescence polarization: methodology and relation to gestational age.

Abstract:

:The fluorescence polarization of 116 amniotic fluid specimens obtained from 22 isoimmunized pregnant women was determined. The degree of fluorescence polarization of amniotic fluid provides an index of microvisocity in lipid aggregates that is dependent on the lecithin-to-sphingomyelin ratio and the degree of saturation of fatty acid side chains. We confirmed the reproducibility of the measurement of amniotic fluid microviscosity (coefficient of variation, 2.0%). The measurements are not effected by bilirubin concentration of amniotic fluid dilution. The pattern of change of amniotic fluid microviscosity during gestation parallels the expected development of the surfactant system. Amniotic fluid microviscosity is high during early gestation and abruptly and sequentially decreases between the 28th and 36th week of gestation. Since the measurements are an accurate reflection of the biochemical properties of amniotic fluid lipids and parallel the development of the surfactant system, we conclude that amniotic fluid microviscosity may well serve as an indicator of the process of fetal lung maturation.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Stark RI,Blumenfeld TA,George JD,Freda VJ,James LS

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

213-8

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

63

pub_type

杂志文章
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

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  • Prescription opioid epidemic and infant outcomes.

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    authors: Patrick SW,Dudley J,Martin PR,Harrell FE,Warren MD,Hartmann KE,Ely EW,Grijalva CG,Cooper WO

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  • Comparison of urinary lactic dehydrogenase with antibody-coated bacteria in the urine sediment as means of localizing the site of urinary tract infection.

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    pub_type: 杂志文章

    doi:

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    更新日期:1979-11-01 00:00:00

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    更新日期:1991-03-01 00:00:00

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