The neurobiological bases of memory formation: from physiological conditions to psychopathology.

Abstract:

:The formation of long-term memories is a function necessary for an adaptive survival. In the last two decades, great progress has been made in the understanding of the biological bases of memory formation. The identification of mechanisms necessary for memory consolidation and reconsolidation, the processes by which the posttraining and postretrieval fragile memory traces become stronger and insensitive to disruption, has indicated new approaches for investigating and treating psychopathologies. In this review, we will discuss some key biological mechanisms found to be critical for memory consolidation and strengthening, the role/s and mechanisms of memory reconsolidation, and how the interference with consolidation and/or reconsolidation can modulate the retention and/or storage of memories that are linked to psychopathologies.

journal_name

Psychopathology

journal_title

Psychopathology

authors

Bisaz R,Travaglia A,Alberini CM

doi

10.1159/000363702

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

347-56

issue

6

eissn

0254-4962

issn

1423-033X

pii

000363702

journal_volume

47

pub_type

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