Abstract:
:In phenobarbital measurement by GLC with the flash-methylation technique, using trimethylanilinium hydroxide as a methylating reagent, a small amount of water decomposed phenobarbital and interfered with the quantitative analysis. Thus, both the sample and the methylating reagent must be sufficiently dehydrated to attain quantitative analyses. The hydrolysis decomposition product of phenobarbital was N-methyl-2-phenylbutyramide, as shown by its mass spectrum. The sum of methylated phenobarbital and N-methyl-2-phenylbutyramide (if observed in the spectrum) can be used for an accurate phenobarbital assay in the present flash-methylation technique.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Kurata K,Takeuchi M,Yoshida Kdoi
10.1002/jps.2600680938subject
Has Abstractpub_date
1979-09-01 00:00:00pages
1187-9issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)42844-8journal_volume
68pub_type
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