Abstract:
OBJECTIVE:To assess the ability of multiparametric prostate magnetic resonance imaging (mpMRI) to detect prostate cancer in patients with prior negative transrectal prostate biopsy (TPB). MATERIAL AND METHODS:mpMRI (TSE-T2-w, DWI and DCE sequences) was performed on 1.5T (Magnetom Avanto; Siemens Healthcare Solutions) in 150 patients suspicious of prostate cancer and with negative TPB. European Society of Urogenital Radiology (ESUR) criteria were used (score 1: clinically significant disease is highly unlikely to be present; score 2: clinically significant cancer is unlikely to be present; score 3: clinically significant cancer is equivocal; score 4: clinically significant cancer is likely to be present; score 5: clinically significant cancer is highly likely to be present). PSA measurement (total and free), digital rectal examination (DRE), transrectal ultrasound (TRU) and a second TPB (at least 14 cylinders) were performed in all patients. Variables were submitted for independent blind analysis. The accuracy of each test was measured. Stepwise selection model for prediction of prostate cancer in second TPB was developed. RESULTS:Mean age was 66.2± 5 years (51-77), mean PSA 11.3± 9.6ng/mL (0.9-75) and mean prostatic volume 82.2±42 (20-250) cc. DRE was suspicious in 11 (7.3%) patients. The mean number of cylinders per patient sampled in second TRB was 17.6±2.7(14-22). Second TRB was positive in 28 patients (18.7%). mpMRI was positive (score 3-5) in 102 (68%), test sensibility was 92.9% and the NPV was 95.8%. The risk of prostate cancer diagnosis in second TPB is modified by: PSA velocity > 0.75 (OR 1.04 [0.99-1.08]; P=0.06), free/total ratio PSA <15% (OR 0.37 [0.13-1.05]; P=0.06), each cc. of prostate volume (OR 0.98 [0.97-1]; P=0.017) and mpMRI 3-5 (OR 7.87 [1.78-34.7]; P=0.006). Multivariate analysis reveals that mpMRI (OR 7.41 [1.65-33.28]; P=0.009) and prostatic volume (OR 0.31 [0.12-0.78]; P=0.01) are independent risk predictors of prostate cancer. CONCLUSIONS:According to ESUR guidelines and in patients with prior negative prostate biopsy, mpMRI is a valuable tool for the prediction of prostate cancer in second TPB. Lower prostate volume, the higher reliability.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Lista F,Castillo E,Gimbernat H,Rodríguez-Barbero JM,Panizo J,Angulo JCdoi
10.1016/j.acuro.2014.07.001subject
Has Abstractpub_date
2015-03-01 00:00:00pages
85-91issue
2eissn
0210-4806issn
1699-7980pii
S0210-4806(14)00306-4journal_volume
39pub_type
杂志文章abstract:CONTEXT:Bladder carcinoma (BC), due its high morbidity and relapsing course, generates significant economic and health care costs. Accordingly, review the environmental nonoccupational risk factors (RF), more or less evidence-based, in the etiology and pathogenesis of BC, because the involvement of urologists is essent...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2013.02.004
更新日期:2013-10-01 00:00:00
abstract:INTRODUCTION:Delayed graft function alter living donor transplantation is a subject of debate. Delayed graft function can be partially explained by renal ischemia-reperfusion injury, when severe is associated with decreased graft survival. In this experimental living donor model study, we analyze the hemodynamic, histo...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/s0210-4806(08)73802-6
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Urolithiasis is a disease having a high recurrence rate and associated morbidity. A not well quantified increase is being seen in recent years that could be related with various factors. The main purpose of our study has been to estimate urolithiasis prevalence and incidence in the region of Andalusia, det...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2014.02.006
更新日期:2015-01-01 00:00:00
abstract::Vesical leiomyoma is a benign mesenchymal tumor that rarely involves the bladder and makes about 1.5% of all vesical tumors. A new case is presented and aspects concerning clinical, diagnostic and surgical issues are examined. The paper includes a revision of the available literature on the topic. ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Presentation of a review of 10 paediatric patients with tumour of the testis vitelline sack, to report our experience in the management of this pathology. Mean age was 20 months (14-32), and the interval of the study was from 1970 to 1994. After orchiectomy, 7 children were included in stage I, 1 in stage II, and 2 in...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Presentation of two cases of leiomyosarcoma of a cava vein, an infrequent retroperitoneal tumour. Both cases were treated by means of anatomical reconstruction by a PTFE prosthesis. Brief review of diagnostic and therapeutical choices. ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:Bladder outlet obstruction with obstructive and irritative urinary symptoms may be a complication of surgery for female urinary incontinence. In presence of persistent symptoms, the therapy is surgical and usually consists in an accurate urethrolysis. The way of approach is generally transvaginal. In this pap...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2011.07.021
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:The prostate cancer is an important cause of men's mortality in our society. PURPOSE:To know the time of delay in to realise the surgical treatment of the prostate cancer. MATERIALS AND METHODS:Analysis of 30 cases of patients treated with radical prostatectomy, cuantifying the time of delay in all the p...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/s0210-4806(03)72922-2
更新日期:2003-04-01 00:00:00
abstract::Prostatic abscesses are an infrequent pathology, probably due to a better and early management of prostatic infections. Predisposing factors in this pathology are diabetes mellitus, urethral catheterism or manipulation, and immunodepressed states like AIDS. Nowadays, ultrasonography is an excellent diagnostic method o...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::Given the nature of the multiple causes of male infertility, some of them are «reversible» and can be managed with a surgical procedure to recover, in some cases, the fertilizing capacity of the male reproductive tract. With appropriate use of diagnostic tools and clinical judgement, the physician can identify the ide...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2019.10.012
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To compare the efficacy of ureteroscopy and extracorporeal shock wave lithotripsy (ESWL) in treating distal ureteral calculi and evaluate the best treatment alternative for this disease. MATERIAL AND METHODS:A total of 104 patients with distal ureteral calculi requiring surgical intervention were enrolled and ...
journal_title:Actas urologicas espanolas
pub_type: 临床试验,杂志文章
doi:10.1016/s0210-4806(09)72874-8
更新日期:2009-09-01 00:00:00
abstract:INTRODUCTION:Partial nephrectomy is widely accepted as a therapeutic modality in renal cell carcinoma (RCC) in patients with single kidney, bilateral tumor or deteriorated renal function. Currently, long-term survival studies have consolidated partial nephrectomy as the treatment of choice for RCC in selected patients ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2011.06.016
更新日期:2012-03-01 00:00:00
abstract::Prostate cancer (PCa) is the fourth most common cancer in the world and treatment is currently based on surgical removal and/or radiotherapy and/or hormone therapy. In the last few years' immunotherapy has become an important cancer treatment option. While the principles of immunotherapy evolved, only sipuleucel-T was...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2020.01.009
更新日期:2020-09-01 00:00:00
abstract::Ongoing changes in the social, economic, technological and scientific realms have generated new needs and led various organizations to suggest that educational institutions should reorient their educational strategies toward developing effective professionals with the skills to meet these needs. These "modern" strateg...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(05)73193-4
更新日期:2005-01-01 00:00:00
abstract::The fate of some infiltrant tumours of the bladder locally advanced (pT2-3NxM0) which were radically resected, with or without association to other treatments, has been similar to those in which initial radical treated was used. To carry out simultaneously a radical RTU as a local action plus systemic chemotherapy (M-...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::Presentation of one case of penis-located multiple skin metastasis from prostate adenocarcinoma after hormonal blockade for 11 years. Revision and update of the topic, corroborating the poor prognosis of these patients. ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::Urinary tract complications continue to be a major cause of morbidity in renal transplant patients. This paper is a review of the urological complications developed in in 200 renal transplants performed in our service over a 10-year period, from January 1980 to December 1989, with a follow-up of at least 1 year. We in...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:INTRODUCTION:Laparoscopic nephron-sparing surgery is among the most complex urological procedures currently performed. Open surgery continues to be the gold standard of care, but the laparoscopic approach is gaining ground slowly but surely. Our 5 years' experience is reported. MATERIALS AND METHODS:From September 200...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract:CONTEXT:Cervical cancer is the second most common tumor in women worldwide and due to diagnostic and therapeutic advances, the overall survival rates at 5 years is approaching 70%. Disorders in micturition, defecation, sexuality and quality of life have been described, frequently caused by different treatments. Address...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2012.03.008
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To create a relational database for monitoring lithiasic patients. We describe the architectural details and the initial results of the statistical analysis. METHODS AND MATERIALS:Microsoft Access 2002 was used as template. Four different tables were constructed to gather demographic data (table 1), clinica...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:There is no high-level evidence as to which primary treatment provides an overall survival (OS) or cancer-specific survival (CSS) advantage in high-risk localised prostate cancer (HRLPC). Our aim was to analyse the differences in survival and predictive factors in this group of patients, acc...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2018.06.006
更新日期:2019-03-01 00:00:00
abstract::In this study we offer a case of spontaneous extraperitoneal vesical rupture and we analyse the etiopathogenic factors that are going to determine the genesis of the process, the diagnostic means used as well as the therapeutic attitude to be followed on the basis of the patient's clinical picture and the bladder leve...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1989-07-01 00:00:00
abstract::About 2% of adults have an urachal cyst. The diagnosis is usually made due to its clinical complications. We report an inusual case of acute urinary retention due to an urachal cyst, with hipogastric pain and anuria as initial syntoms. ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(05)73365-9
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To determine the values of PSA in Spanish workers without history of prostate problems and compare them with other geographical latitudes. METHODS:Observational, retrospective, multicenter and population-based study, conducted between January 1 and December 31, 2006. A total of 65303 workers participated in ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,多中心研究
doi:
更新日期:2010-09-01 00:00:00
abstract::Primary amyloidosis of the bladder is a rare disease entity manifested as extracellular deposits of a fibril protein in an amyloid substance form. Clinical presentation resembles a bladder tumor, as hematuria is the most common clinical manifestation. Single organ affectation is most frequent in the bladder, however, ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(01)72666-6
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To analyse the differences in the postoperative period between bipolar and monopolar resection of the prostate in the endoscopic surgery of the benign prostatic hyperplasia. METHODS:45 patients were prospectively randomized. Twenty-one underwent monopolar resection (Storz Ch 26, 30 degrees) and 24 underwent ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,随机对照试验
doi:10.1016/s0210-4806(06)73515-x
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:NF-kB (p50/p65) is a transcription factor involved in TNF-α-induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB (p50 and p65) with serum levels of prostate-specific antigen (PSA), both in normal males and in those with pathologic conditions of...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2010.08.002
更新日期:2011-01-01 00:00:00
abstract::Lately, nuclear morphometry methods are being used to analyze the malignant potential of tumoral cells. This paper presents a retrospective study of a series of 163 patients with the three histological grades (WHO), of superficial papillary transitional cell carcinoma (pTa-pT1) of the bladder with a mean follow-up of ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Penile fibrosis due to previous penile infection and/or prosthesis explants entails situations of high surgical complexity. In these cases, reimplantation should follow an alternative scheme, aimed at minimizing perioperative and postoperative complications, as well as achieving maximum efficiency of the procedure and...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2019.10.001
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION:For the treatment of the urinary stress incontinence, there are many techniques, and today the gold standard is that described by Burch. We compared the global and each technique results about rates of postoperative continence and complications seen in our experience. MATERIALS AND METHODS:We made a retro...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(07)73740-3
更新日期:2007-09-01 00:00:00