Abstract:
:The nonspecies specific immunosuppressive and anti-inflammatory properties of a major protein (SV-IV) secreted from the epithelium of rat seminal vesicles (SV) are described. To detect the immunosuppressive effect, peripheral blood lymphocytes (PBL) were pretreated for 2 hr at 37 degrees with SV-IV, and the protein was maintained in the incubation medium during the whole culture time. We obtained evidence that, during preincubation of PBL and SV-IV the protein was transformed by a transglutaminase (TGase) released from PBL into modified low and high molecular weight forms able to bind to PBL surfaces. It is suggested that T lymphocytes are the possible targets of the immunosuppressive effect. SV-IV seems to inhibit only the early phase of the proliferative response of T lymphocytes to mitogens without having any direct effect on the enzymatic system involved in DNA synthesis. Moreover, the protein SV-IV was also shown to possess an anti-inflammatory property due to a block of the arachidonic acid cascade at the level of the enzyme phospholipase A2 (PLA2). The physiological significance of the immunosuppressive and anti-inflammatory properties of SV-IV are discussed in relation to different aspects of the mammalian reproduction.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Metafora S,Peluso G,Persico P,Ravagnan G,Esposito C,Porta Rdoi
10.1016/0006-2952(89)90158-5subject
Has Abstractpub_date
1989-01-01 00:00:00pages
121-31issue
1eissn
0006-2952issn
1873-2968pii
0006-2952(89)90158-5journal_volume
38pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Biochemical pharmacology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(96)00457-1
更新日期:1996-10-11 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1984-11-01 00:00:00