Abstract:
:We describe 2 adult women (72 and 54 years), 1 with a low-grade noninvasive papillary urothelial carcinoma of the renal pelvis, who 14 years later developed a papillary carcinoma in 1 thyroid lobe and a medullary carcinoma in the contralateral lobe. Both neoplasms were similar in size and appeared symmetrical. Despite its small size, the medullary carcinoma metastasized in multiple cervical lymph nodes. The second patient had a high-grade invasive papillary urothelial carcinoma of the renal pelvis that infiltrated the renal parenchyma and metastasized in one of the lungs. Five months later, a papillary carcinoma was discovered in the thyroid gland. The 2 papillary thyroid carcinomas were of the follicular variant. Adjacent to 1 papillary carcinoma, there was a dominant nodule of a colloid and adenomatous goiter. The medullary carcinoma contained stromal amyloid and was immunoreactive for calcitonin and carcinoembryonic antigen. There was no C-cell hyperplasia (medullary carcinoma in situ). The 2 patients are alive, 1 is living with pulmonary metastasis from the high-grade urothelial carcinoma. Twelve cases of this neoplastic association were registered in the Survey, Epidemiology, and End Results Program from 1980 to 2009. We believe that the combination of these unusual neoplasms in the same patient may represent a new sporadic neoplastic syndrome.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Albores-Saavedra J,Dorantes-Heredia R,Chablé-Montero F,Córdova-Ramón JC,Henson DEdoi
10.1016/j.anndiagpath.2014.08.003subject
Has Abstractpub_date
2014-10-01 00:00:00pages
286-90issue
5eissn
1092-9134issn
1532-8198pii
S1092-9134(14)00069-0journal_volume
18pub_type
杂志文章abstract::The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to m...
journal_title:Annals of diagnostic pathology
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doi:10.1016/j.anndiagpath.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::Apocrine metaplasia (APM) is a common finding in the breast of postmenopausal women and is seen in a broad spectrum of lesions ranging from microscopic cysts to invasive apocrine carcinoma. Apocrine metaplasia within sclerosing adenosis is known as apocrine adenosis (AA) and is considered a benign lesion of the breast...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.05.001
更新日期:2010-02-01 00:00:00
abstract::Approximately 15% of patients with high-grade cervical intraepithelial neoplasia (CIN 2-3), treated by the loop electrosurgical excision procedure (LEEP) will experience a persistence or recurrence of their disease. The full spectrum of pathologic factors that may be predictive of an increased probability of this even...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2007.01.012
更新日期:2008-02-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(03)00073-x
更新日期:2003-08-01 00:00:00
abstract::A few cases of uterine angiosarcoma have been detailed in the literature: 2 new cases are herein described featuring some unusual clinical or phenotypic differences compared with previously published cases, such as occurrence in premenopausal age or a poorly differentiated histology. The patients were 35 and 81 years ...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2007.08.001
更新日期:2008-06-01 00:00:00
abstract::We report a case of recurrent body cavity-based non-Hodgkin's lymphoma in a patient with advanced acquired immunodeficiency syndrome who presented with bilateral pleural effusions, without evidence of an associated tumor mass. The lymphoma cells were large and pleomorphic, lacking pan-T- and pan-B-cell markers, but ex...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(98)80050-6
更新日期:1998-04-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2005.09.002
更新日期:2006-08-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/adpa.2001.27923
更新日期:2001-10-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.05.006
更新日期:2009-12-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(98)80032-4
更新日期:1998-02-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/s1092-9134(99)80006-9
更新日期:1999-02-01 00:00:00
abstract::The purpose of the study is to assess whether a protocol for submitting clinically suspected endometrial polyps will improve the detection rate of polyps and evaluation of the background endometrium. A retrospective review from 1999 to 2015 was performed. Cases were divided into (1) polyps and curettings placed in 2 c...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2016.05.002
更新日期:2016-08-01 00:00:00
abstract::Triple negative breast cancer (TNBC) represents a small subtype of breast cancer yet it has the worst outcome. Immunotherapy using immune checkpoint inhibitors combined with chemotherapy was recently approved by the FDA raising the hope for an improved outcome. The approval was based on demonstration of a positive PD-...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2021.151703
更新日期:2021-01-09 00:00:00
abstract::According to colleagues specializing in genitourinary pathology, the so-called postoperative spindle cell nodule of the bladder can be extremely difficult to distinguish from a spindle cell sarcomatoid carcinoma. What I have learned in 25 years about spindle cell sarcomatoid carcinoma of the larynx may, by analogy, po...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/j.anndiagpath.2004.01.009
更新日期:2004-04-01 00:00:00
abstract::Intraductal lesions of the pancreas are an uncommon but increasingly recognized group of entities mainly because of advances in imaging technology. In the past, precise categorization and understanding of true pancreatic intraduct neoplasms were hampered not only by their relative rarity but also because of the pletho...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2016.04.009
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2017.02.003
更新日期:2017-06-01 00:00:00
abstract::Brain in the middle ear or nasal cavity: heterotopia or encephalocele? The answer to this question is greatly influenced by clinical information. Sometimes, however, this information is insufficient and the pathologist's opinion may influence patient management. It seems that most pathologists tend to get the answer w...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/j.anndiagpath.2004.04.009
更新日期:2004-08-01 00:00:00
abstract::Myospherulosis is a rare tumor caused by interaction of extravasated erythrocytes and exogenous or endogenous lipids. Fifty-nine articles presented 181 patients with myospherulosis since first description in 1969. Myospherulosis seems to occur in any age and in any part of the body; however, most frequent sites are pa...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2012.12.003
更新日期:2013-08-01 00:00:00
abstract::Core needle biopsy (CNB) is the most common sampling technique for the histologic evaluation of breast abnormalities. Diagnosing benign proliferative, borderline and some in-situ lesions in CNB is challenging and subject to a significant degree of interobserver variability. In addition, due to the inherent limitations...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2019.151407
更新日期:2019-12-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2016.08.005
更新日期:2017-02-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2008.02.014
更新日期:2009-06-01 00:00:00
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journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/s1092-9134(97)80013-5
更新日期:1997-12-01 00:00:00
abstract::Breast carcinoma with osteoclast-like giant cells (OGCs) is a rare disease characterized by the infiltration of OGCs in the tumor; however, cytological aspects of this tumor type remain elusive. We examined the cytological features in fine needle aspiration (FNA) biopsy smears obtained from 5 patients who were histolo...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2017.11.003
更新日期:2018-04-01 00:00:00
abstract::Lymphoglandular bodies (LGBs) have been described as cytoplasmic fragments of lymphocytes and a specific feature of organized lymphoid tissue. The recognition of LGBs is useful in distinguishing malignant lymphomas from carcinomas and sarcomas in cytology specimens, especially in Giemsa-stained tissues. So far, there ...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2007.10.001
更新日期:2008-08-01 00:00:00
abstract::We report a case of synovial chondromatosis of the tibiofibular joint in a 25-year-old woman that was diagnosed by fine-needle aspiration (FNA). The patient presented with pain in the left knee and a mass in the popliteal fossa. Synovial chondromatosis usually presents with joint symptoms and is often associated with ...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(00)90015-7
更新日期:2000-04-01 00:00:00
abstract::A 4-cm paravertebral mediastinal tumor was resected in a 70-year-old male patient treated for hypertension. The tumor displayed both paraganglioma and ganglioneuroma areas that were in equal proportion and often merged one into the other. Paraganglioma areas contained synaptophysin and chromogranin-positive chief cell...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2004.12.010
更新日期:2005-04-01 00:00:00
abstract::Uterine smooth muscle tumors are usually spindle cell lesions, but a minority is composed of epithelioid cells. Foci of clear cells can be found in these latter tumors. Recently, it has been shown that some of these tumors can be positive for HMB45, and some authors have advocated calling these lesions perivascular ep...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1053/j.anndiagpath.2004.10.011
更新日期:2005-02-01 00:00:00
abstract::A 57-year-old man had an expanding cystic lesion of the anterior maxilla that demonstrated destruction and disruption of local structures. A cystic odontogenic neoplasm as well as various forms of odontogenic carcinoma was suspected. Incisional biopsy and microscopic examination revealed an aggressive epithelial odont...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(99)80056-2
更新日期:1999-08-01 00:00:00
abstract::An uncommon manifestation of plasma cell neoplasia occurs outside the bone marrow and is designated "extramedullary plasmacytoma." These are usually encountered in mucosal sites of the head and neck region. The gastrointestinal tract may be secondarily involved in multiple myeloma or be the site of primary extramedull...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(03)00017-0
更新日期:2003-06-01 00:00:00
abstract::The purpose of this study is to assess whether composite or coordinate immunoexpression patterns of estrogen receptor (ER), progesterone receptor (PR), and Wilms tumor 1 (WT1) gene can significantly distinguish between endometrial serous carcinoma (ESC) and ovarian serous carcinoma (OSC). Immunohistochemical analyses ...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2013.04.011
更新日期:2013-10-01 00:00:00