Abstract：
:Although the use of monoclonal antibodies to characterize the Ia antigen system is still in its infancy, the usefulness of this approach is clearly apparent. Since xenogeneic immunization can be used to generate these antibodies, the chances are good that a greater variety of Ia types and determinants will be detected compared to those detected with conventional alloantisera. In addition, the advantages of unlimited quantity and constant specificity allow a much greater degree of standardization than was previously possible. Finally, monoclonal antibodies open up lines of investigation, such as the examination of correlations between the monoclonal antibody's inhibition of T-cell proliferation and the antibody's corresponding Ia epitope-binding characteristics, that it would be impossible to approach using conventional alloantisera.
journal_name
Methods Enzymoljournal_title
Methods in enzymologyauthors
Zweig SE,Shevach EMdoi
10.1016/0076-6879(83)92010-4subject
Has Abstractpub_date
1983-01-01 00:00:00pages
66-85eissn
0076-6879issn
1557-7988journal_volume
92pub_type
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journal_title：Methods in enzymology
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更新日期：2007-01-01 00:00:00
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abstract：:Mitochondria are considered one of the main sources of reactive oxygen species (ROS). The overgeneration of ROS can evoke an intracellular state of oxidative stress, leading to permanent cell damage. Thus, the intracellular accumulation of ROS may not only disrupt the functions of specific tissues and organs but also ...
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abstract：:Benzylisoquinoline alkaloids (BIAs) constitute a diverse class of plant secondary metabolites that includes the opiate analgesics morphine and codeine. Collectively, BIAs exhibit a myriad of pharmacological activities, including antimicrobial, antitussive, antispasmodic, and anticancer properties. Despite 2500 known B...
journal_title：Methods in enzymology
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