Changes of the fibrinolytic system of animals induced by injection of tissue plasminogen activator.

abstract：:Acutely ill medical patients are at moderate to high risk of venous thromboembolism (VTE): approximately 10-30% of general medical patients may develop deep-vein thrombosis or pulmonary embolism, and the latter is a leading contributor to deaths in hospital. Medical conditions associated with a high risk of VTE includ...

journal_title：Thrombosis research

authors： Cohen AT,Nandini B,Wills JO,Ota S

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Systemic embolism is the most serious complication of cardioversion of atrial fibrillation (AF) and the immediate post-cardioversion period is associated with increased risk for thrombus formation. For this reason, treatment with vitamin K antagonist (VKA) is recommended for patients with AF. No informatio...

journal_title：Thrombosis research

authors： Poli D,Antonucci E,Grifoni E,Paoletti O,Rancan E,Dentali F,Testa S

更新日期：2012-05-01 00:00:00

abstract：:The effect of tissue factor pathway inhibitor (TFPI) on thrombin and factor Xa generation was studied in an in vitro system using a prothrombin complex concentrate. It was found that TFPI, via the direct inhibition of factor Xa and the tissue factor/factor VIIa complex, inhibited both the further generation of factor ...

journal_title：Thrombosis research

authors： Kaiser B,Hoppensteadt DA,Jeske W,Wun TC,Fareed J

更新日期：1994-09-15 00:00:00

abstract：:Many patients with diabetes mellitus show increased platelet aggregation and prostaglandin synthesis in response to physiological agents such as ADP and collagen when their platelets are tested in platelet-rich plasma or washed platelet suspensions. However, the relationship between increased platelet aggregation in v...

journal_title：Thrombosis research

authors： Ingerman-Wojenski CM,Smith M,Silver MJ

更新日期：1987-06-01 00:00:00

abstract：:The von Willebrand factor (vWF) is found in plasma and in platelets. The concentration and multimeric composition of the vWF in platelets of 160 patients with bleeding tendency were examined since very little is known about the platelet vWF. For quantitative analysis of the platelet vWF, a modified ELISA was establish...

journal_title：Thrombosis research

authors： Eller T,Brauer P,Albert J,Mayer J,Keller F

更新日期：1992-03-01 00:00:00

abstract：:The Coa-set Fibrin Monomer test (CFM-test) is a quantitative method for determination of soluble fibrin in plasma. The fibrin standard of the CFM-test is produced by bathroxobin conversion of purified fibrinogen to fibrin. Plasma treated with minute amounts of thrombin may be considered as a more physiological way of ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Godal HC

更新日期：1993-11-15 00:00:00

abstract：:Aggregation responses of platelet-rich plasma (PRP) from monocrotaline pyrrole (MCTP)-treated rats were examined to help elucidate the role of platelets in MCTP-induced pulmonary hypertension. PRP from rats treated one or four days earlier with MCTP (5 mg/kg, i.v.) or vehicle exhibited the same slope and maximum aggre...

journal_title：Thrombosis research

authors： Hilliker KS,Deyo JA,Bell TG,Roth RA

更新日期：1983-11-01 00:00:00

abstract：:Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...

journal_title：Thrombosis research

authors： Ettelaie C,Howell RM

更新日期：1992-10-15 00:00:00

abstract：AIM:Mean platelet volume (MPV) in the healthy population has not been studied before. Therefore, the aim of the study was to measure MPV in normal subjects in a large cohort of Turkish adults. METHODS:A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. Subjects who had smoking habit, ...

journal_title：Thrombosis research

authors： Demirin H,Ozhan H,Ucgun T,Celer A,Bulur S,Cil H,Gunes C,Yildirim HA

更新日期：2011-10-01 00:00:00

abstract：:Dextran sulfate and polybrene were immobilized on polypropylene tubes with plastic adhesive. Serum albumin was also immobilized on the tube by heat-denaturation. In the those tubes thrombin was protected from inactivation in the presence of 0.1 M NaCl remarkably. Cholesterol coated on the tube also protected the enzym...

journal_title：Thrombosis research

authors： Oshima G

更新日期：1988-07-01 00:00:00

abstract：:Hemorrhagic and thrombotic complications are common in the term and preterm infant. Limited information is currently available about neonatal platelet structure and function, and how these may predispose infants to bleeding problems. This study comparing platelet ultrastructure of 71 different term and preterm infants...

journal_title：Thrombosis research

authors： Saving KL,Jennings DE,Aldag JC,Caughey RC

更新日期：1994-03-15 00:00:00

abstract：:The prevention of venous thromboembolism (VTE) in women with cancer requires special consideration. The presence of cancer results in both non-surgical and surgical patients having increased risk of VTE. This usually leads to a modification of the recommended preventive therapy, affecting the type, dose and length of ...

journal_title：Thrombosis research

authors： Cohen AT,Wills JO,Bharathi N,Solis JV

更新日期：2011-02-01 00:00:00

abstract：:Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thromb...

journal_title：Thrombosis research

authors： Berliner JI,Rybicki AC,Kaplan RC,Monrad ES,Freeman R,Billett HH

更新日期：2002-07-15 00:00:00

abstract：INTRODUCTION:Inherited abnormalities of fibrinogen (FG) are rare coagulation disorders divided into two types: quantitative abnormalities (afibrinogenemia and hypofibrinogenemia) or qualitative abnormalities (dysfibrinogenemia and hypo-dysfibrinogenemia) of circulating fibrinogen. In particular, congenital afibrinogene...

journal_title：Thrombosis research

authors： Amri Y,Toumi Nel H,Hadj Fredj S,de Moerloose P

更新日期：2016-07-01 00:00:00

abstract：:The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...

journal_title：Thrombosis research

authors： Beebe DP,Aronson DL

更新日期：1988-07-01 00:00:00

abstract：:Using a stable cross-linked SAK/plg complex, the effects of alpha 2-plasmin inhibitor on plasminogen activation by SAK were investigated. alpha 2-Plasmin inhibitor inhibited dose-dependently plasminogen activation by the SAK/plg complex. When FCB-2 or EACA was added to the reaction mixture of SAK/plg complex and alpha...

journal_title：Thrombosis research

authors： Okada K,Nonaka T,Matsumoto H,Fukao H,Ueshima S,Matsuo O

更新日期：1994-10-15 00:00:00

abstract：INTRODUCTION:Plasminogen activator inhibitor (PAI-1) may have an independent prognostic value in breast cancer (BC). PAI-1 4G/5G polymorphism may have significance for antigen expression. Thus, we analyzed the possible associations between PAI-1 4G/5G polymorphism, plasma PAI-1 levels, and clinicopathological features ...

journal_title：Thrombosis research

authors： Palmirotta R,Ferroni P,Savonarola A,Martini F,Ciatti F,Laudisi A,Sini V,Del Monte G,Guadagni F,Roselli M

更新日期：2009-09-01 00:00:00

abstract：:The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this ...

journal_title：Thrombosis research

authors： Lenk H

更新日期：2014-11-01 00:00:00

abstract：:The incidence of thrombotic events is higher in neonates compared to children of other age groups. Perinatal and maternal risk factors, as well as the developing neonatal hemostatic system, are contributing factors in the higher rate of thrombosis in this pediatric population. This review summarizes the available lite...

journal_title：Thrombosis research

authors： Yang JY,Chan AK

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:The contact system proteins factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK) have roles in coagulation, fibrinolysis, thrombin-induced platelet activation, cell adhesion and angeogenisis. It has been suggested that inherited or acquired deficiencies of these proteins may be ri...

journal_title：Thrombosis research

authors： Gallimore MJ,Harris SL,Jones DW,Winter M

更新日期：2004-01-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been recognized as associated with ischemic heart disease (IHD) although the optimal set of risk genotypes has not be identified. This study aimed to examine whether identified high-risk SNPs are associated with early onset of IHD. In the GENOCOR study, 44 high-risk ...

journal_title：Thrombosis research

authors： Vecoli C,Adlerstein D,Shehi E,Bigazzi F,Sampietro T,Foffa I,Carpeggiani C,L'abbate A,Andreassi MG

更新日期：2014-05-01 00:00:00

abstract：:The influence of red blood cells on platelet aggregation has recently been a subject of considerable interest. We have studied the effect of red cells on spontaneously formed platelet aggregates in rotating vials at 37 degrees C. Platelet aggregation was quantified by measuring the fall in number of single platelets w...

journal_title：Thrombosis research

authors： Saniabadi AR,Lowe GD,Barbenel JC,Forbes CD

更新日期：1985-05-01 00:00:00

abstract：:Concentration-response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 le...

journal_title：Thrombosis research

authors： Vrzheshch PV,Tatarintsev AV,Yershov DE,Varfolomeyev SD

更新日期：1992-06-01 00:00:00

abstract：:An in vivo rabbit model of venous thrombosis which includes physiological blood flow was used to compare the efficacy of the potent and specific factor Xa inhibitor recombinant tick anticoagulant peptide (rTAP) with standard heparin in the prevention of venous thrombus formation. In anesthetized rabbits, an autologous...

journal_title：Thrombosis research

authors： Fioravanti C,Burkholder D,Francis B,Siegl PK,Gibson RE

更新日期：1993-08-15 00:00:00

abstract：:Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss (MBL) >80 mL per cycle, that interferes with a woman's physical, emotional, social wellbeing and quality of life. Aetiology is due to underlying uterine pathologies, coagulopathy, ovulation dysfunction, or iatrogenic. Up to 20% of women with H...

journal_title：Thrombosis research

authors： Davies J,Kadir RA

更新日期：2017-03-01 00:00:00

abstract：:Cardiovascular diseases are one of the leading causes of morbidity and mortality in industrialized countries, and although many processes play a role in the development of vascular disease, thrombosis is the primary event that precipitates stroke and acute coronary syndromes. The blood platelets are of significant imp...

journal_title：Thrombosis research

authors： Alexandru N,Popov D,Georgescu A

更新日期：2012-02-01 00:00:00

abstract：:Ticlopidine (100 mg/kg/day or 400 mg/kg/day) was administered to rats and rabbits for 48 hr before and during the experiments. Aggregation studies of twice-washed platelets resuspended in Tyrode solution containing apyrase and 0.35% albumin showed that inhibition by ticlopidine of aggregation induced by ADP, collagen,...

journal_title：Thrombosis research

authors： Cattaneo M,Winocour PD,Somers DA,Groves HM,Kinlough-Rathbone RL,Packham MA,Mustard JF

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Maximal exercise may be a trigger for cardiovascular events. The aim of the study was to investigate changes in blood coagulation and fibrinolysis following maximal short-term exercises with different durations up to 90 s. METHODS:A total of 15 healthy nonsmokers underwent three isokinetic maximal tests o...

journal_title：Thrombosis research

authors： Hilberg T,Prasa D,Stürzebecher J,Gläser D,Schneider K,Gabriel HH

更新日期：2003-03-15 00:00:00

abstract：:Whilst the term cancer associated thrombosis (CAT) offers an overarching term for all thrombotic events encountered during the cancer journey, the reality is that this is a far too simplistic reflection of a complex multifactorial process occurring within a heterogeneous population. The management of CAT needs to cons...

journal_title：Thrombosis research

authors： Noble S,Sui J

更新日期：2016-04-01 00:00:00

abstract：:Activation of the coagulation and inflammatory systems are physiologically occurring during pregnancy. However, excess activation of either system is well documented in gestational vascular diseases (GVD). GVD are placenta-mediated pregnancy complications and a major cause of feto-maternal morbidity and mortality. The...

journal_title：Thrombosis research

authors： Kohli S,Isermann B

更新日期：2017-03-01 00:00:00