Abstract:
:Slow channel inhibiting agents, particularly verapamil, appear to produce beneficial effects in relieving symptoms of dyspnea, chest pain, and syncope or presyncope in over 70% of patients with hypertrophic cardiomyopathy. Symptomatic relief occurs in patients with and without left ventricular outflow obstruction. Exercise hemodynamics, exercise tolerance, and cardiac performance during exercise tend to improve. The mechanisms for this symptomatic improvement, however, are not fully explained. Relief of symptoms is observed irrespective of any changes in the resting or provocable left ventricular outflow gradient. Similarly, changes in left ventricular systolic function, which in general remains unaffected, cannot be the basis for the beneficial response. Slow channel inhibiting agents, however, appear to improve left ventricular diastolic function, the mechanism of which is yet to be elucidated. Nevertheless, improved left ventricular diastolic function may provide an explanation for the relief of some symptoms in patients with hypertrophic cardiomyopathy. The influence of therapy with slow channel inhibiting agents on arrhythmias, sudden death, and on long-term prognosis of patients with hypertrophic cardiomyopathy remains uncertain at the present time and should be the subject of future investigations.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Chatterjee K,Raff G,Anderson D,Parmley WWdoi
10.1016/0033-0620(82)90016-0subject
Has Abstractpub_date
1982-11-01 00:00:00pages
193-210issue
3eissn
0033-0620issn
1873-1740pii
0033-0620(82)90016-0journal_volume
25pub_type
杂志文章,评审abstract::The sympathetic nervous system occupies a prominent role in heart failure both as a marker of severity of disease and also as an important factor in its progression. Beta blocker therapy, once thought heretical in heart failure, has consistently improved cardiac function and slowed progression of disease. Large clinic...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.1999.0410301
更新日期:1999-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.pcad.2019.01.004
更新日期:2019-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2006.08.008
更新日期:2006-11-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(05)80013-1
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2000.19314
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(78)90015-4
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2007.11.006
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2010.02.003
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abstract::The application of ultrasound to clinical evaluation of the symptomatic patient requires less precision and accuracy than when it is used as an instrument to study atherogenesis. The clinician's goal is to locate hemodynamically significant lesions; studies of atherogenesis require auxometry (measurement of the growth...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章
doi:10.1016/0033-0620(84)90007-0
更新日期:1984-01-01 00:00:00
abstract::The success of modern therapies in congenital heart disease has produced a large and growing population of adults with congenital heart disease as a chronic condition. Such success increasingly raises a host of ethical issues, from resource utilization to end of life decision-making. The importance of a multidisciplin...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.10.004
更新日期:2012-11-01 00:00:00
abstract::During the past decade, an overall theme has emerged, validating the exploration of gender-based differences in coronary heart disease (CHD) as a basis for clinical strategies to improve outcomes for women. Underrepresentation of women in most of CHD and lack of gender-specific reporting in many clinical trials contin...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2003.08.003
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To assess the cardiorespiratory fitness (CRF) impact on the association between exercise blood pressure (BP) and mortality risk. PATIENTS AND METHODS:We assessed CRF in 15,004 US Veterans (mean age 57.5 ± 11.2 years) who completed a standardized treadmill test between January 1, 1988 and July 28, 2017 and ha...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2021.01.003
更新日期:2021-01-26 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2000.0420273
更新日期:2000-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2020.06.003
更新日期:2020-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.01.008
更新日期:2018-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,多中心研究,评审
doi:10.1016/j.pcad.2011.02.001
更新日期:2011-03-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2009.09.002
更新日期:2009-11-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2020.10.004
更新日期:2020-10-24 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章
doi:10.1053/pcad.2001.20501
更新日期:2001-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 历史文章,杂志文章
doi:10.1016/j.pcad.2010.01.001
更新日期:2010-07-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2014.05.009
更新日期:2014-07-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.10.001
更新日期:2018-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章
doi:10.1016/j.pcad.2017.08.005
更新日期:2017-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(77)90004-4
更新日期:1977-09-01 00:00:00
abstract::The recent advent of an entirely subcutaneous implantable defibrillator (ICD) has provided a relevant contribution to the debate concerning the use of ICD therapy in patients at high risk for death. Although conventional transvenous ICDs have proven very effective during the past 23 years, they still appear to be limi...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.03.006
更新日期:2012-05-01 00:00:00
abstract::Left ventricular (LV) dysfunction has been shown to be significantly related to ongoing myocardial ischemia, hibernation, and thus, coronary artery disease. Current treatments for patients with LV dysfunction and concomitant coronary artery disease center around the potential benefit of coronary revascularization, in ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2013.01.003
更新日期:2013-03-01 00:00:00
abstract::Trastuzumab is the standard of care for the treatment of patients with ERB2-positive breast cancer. In a minority of patients, trastuzumab is associated with an increased incidence of cardiac dysfunction that ranges from asymptomatic decreases in left ventricular ejection fraction to symptomatic heart failure. In tria...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2010.07.001
更新日期:2010-09-01 00:00:00
abstract::Beta blockers have long been used in patients who have experienced a myocardial infarction. However, many new therapies are available for this patient group, and as a result, the current role of beta blockers may have become uncertain. In this article we address a series of questions related to the important and conti...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2002.31586
更新日期:2002-01-01 00:00:00