Hypertrophic cardiomyopathy--therapy with slow channel inhibiting agents.


:Slow channel inhibiting agents, particularly verapamil, appear to produce beneficial effects in relieving symptoms of dyspnea, chest pain, and syncope or presyncope in over 70% of patients with hypertrophic cardiomyopathy. Symptomatic relief occurs in patients with and without left ventricular outflow obstruction. Exercise hemodynamics, exercise tolerance, and cardiac performance during exercise tend to improve. The mechanisms for this symptomatic improvement, however, are not fully explained. Relief of symptoms is observed irrespective of any changes in the resting or provocable left ventricular outflow gradient. Similarly, changes in left ventricular systolic function, which in general remains unaffected, cannot be the basis for the beneficial response. Slow channel inhibiting agents, however, appear to improve left ventricular diastolic function, the mechanism of which is yet to be elucidated. Nevertheless, improved left ventricular diastolic function may provide an explanation for the relief of some symptoms in patients with hypertrophic cardiomyopathy. The influence of therapy with slow channel inhibiting agents on arrhythmias, sudden death, and on long-term prognosis of patients with hypertrophic cardiomyopathy remains uncertain at the present time and should be the subject of future investigations.


Prog Cardiovasc Dis


Chatterjee K,Raff G,Anderson D,Parmley WW




Has Abstract


1982-11-01 00:00:00














  • CT Assessment of Myocardial Perfusion and Fractional Flow Reserve.

    abstract::Coronary computed tomography angiography (CTA) offers a non-invasive method to detect coronary plaque and stenosis. However, to date, CTA has been most useful as a method of ruling out coronary artery disease (CAD) among patients with low to intermediate pretest probability of significant CAD. The reduced specificity ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Hulten E,Ahmadi A,Blankstein R

    更新日期:2015-05-01 00:00:00

  • An Update on the Role of Cardiorespiratory Fitness, Structured Exercise and Lifestyle Physical Activity in Preventing Cardiovascular Disease and Health Risk.

    abstract::The cardiovascular disease (CVD) pandemic has placed considerable strain on healthcare systems, quality of life, and physical function, while remaining the leading cause of death globally. Decades of scientific investigations have fortified the protective effects of cardiorespiratory fitness (CRF), exercise training, ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Ozemek C,Laddu DR,Lavie CJ,Claeys H,Kaminsky LA,Ross R,Wisloff U,Arena R,Blair SN

    更新日期:2018-01-01 00:00:00

  • Optimal use of coronary care units: a review.

    abstract::Patients at a low probability of acute cardiac pathology constitute a considerable proportion in many coronary care units (CCUs), such that physicians should consider more effective alternatives than CCU admission "to rule out myocardial infarction." In this article, strategies to increase the efficiency of managing p...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Grijseels EW,Deckers JW,Hoes AW,Hartman JA,van der Does E,Simoons ML

    更新日期:1995-05-01 00:00:00

  • Benefits of the Mediterranean Diet: Insights From the PREDIMED Study.

    abstract::The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-vir...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Martínez-González MA,Salas-Salvadó J,Estruch R,Corella D,Fitó M,Ros E,PREDIMED INVESTIGATORS.

    更新日期:2015-07-01 00:00:00

  • The 'perfect storm' and acute coronary syndrome onset: do psychosocial factors play a role?

    abstract::The revolution in cardiac care over the past two decades, characterized by emergent revascularization, drug eluting stents, anti-platelet medications, and advanced imaging has had little impact on overall ACS recurrence, or ACS prevention. The "Perfect Storm" refers to a confluence of events and processes, including a...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Burg MM,Edmondson D,Shimbo D,Shaffer J,Kronish IM,Whang W,Alcántara C,Schwartz JE,Muntner P,Davidson KW

    更新日期:2013-05-01 00:00:00

  • Cardiovascular adjustments to exercise: hemodynamics and mechanisms.

    abstract::The integrated response to severe exercise involves fourfold to fivefold increases in cardiac output, which are due primarily to increases in cardiac rate and to a lesser extent to augmentation of stroke volume. The increase in stroke volume is partly due to an increase in end-diastolic cardiac size (Frank-Starling me...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Vatner SF,Pagani M

    更新日期:1976-09-01 00:00:00

  • Initial Assessment and Triage of the Stroke Patient.

    abstract::Nearly 800,000 strokes occur in the United States each year, and stroke is the leading cause of preventable permanent disability. Timely recognition and treatment are imperative to reduce stroke-related morbidity and mortality. Given the evidence supporting intravenous thrombolysis and mechanical thrombectomy for isch...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Zweifler RM

    更新日期:2017-01-01 00:00:00

  • Implementing movement at the workplace: Approaches to increase physical activity and reduce sedentary behavior in the context of work.

    abstract::The purpose of this article is to highlight approaches to increase movement, physical activity (PA), and cardiorespiratory fitness, and reduce sedentary behavior (SB) in the context of the workplace. A deliberate strategy that will enable the successful promotion of movement at the workplace includes a business plan a...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Pronk NP

    更新日期:2020-10-24 00:00:00

  • The contribution of the Framingham Heart Study to the prevention of cardiovascular disease: a global perspective.

    abstract::The Framingham Heart Study has been a trailblazer in the field of cardiovascular epidemiology. The wealth of novel scientific data that it has generated over 5 decades has made a significant contribution to cardiovascular disease (CVD) prevention in the United States and indirectly influenced global CVD prevention str...

    journal_title:Progress in cardiovascular diseases

    pub_type: 历史文章,杂志文章


    authors: Mendis S

    更新日期:2010-07-01 00:00:00

  • Biology of ischemic cerebral cell death.

    abstract::With the approval of alteplase (tPA) therapy for stroke, it is likely that combination therapy with tPA to restore blood flow, and agents like glutamate receptor antagonists to halt or reverse the cascade of neuronal damage, will dominate the future of stroke care. The authors describe events and potential targets of ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Small DL,Morley P,Buchan AM

    更新日期:1999-11-01 00:00:00

  • Infective endocarditis of the mitral valve: optimal management.

    abstract::Infective endocarditis continues to be associated with significant morbidity and mortality despite recent advances in its management and remains a serious and challenging condition requiring a multidisciplinary approach. Surgery is essential in at least 50% of cases. Surgical outcomes have improved with the introducti...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Zakkar M,Chan KM,Amirak E,Herrey A,Punjabi PP

    更新日期:2009-05-01 00:00:00

  • Epidemiology, risk factors, and consequences of obstructive sleep apnea and short sleep duration.

    abstract::We will review the epidemiology, risk factors, and consequences of obstructive sleep apnea (OSA) and short/long sleep duration. Obstructive sleep apnea is a disease characterized by recurrent upper airway obstruction during sleep. Obstructive sleep apnea is common, with moderate to severe disease present in approximat...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Al Lawati NM,Patel SR,Ayas NT

    更新日期:2009-01-01 00:00:00

  • Systolic dysfunction in heart failure with normal ejection fraction: speckle-tracking echocardiography.

    abstract::Left ventricular (LV) ejection fraction (EF) and LV end-systolic volumes are important measures of LV global function. However, in many patients with symptoms of heart failure, these measures are within normal limits. This condition is classified as heart failure with normal ejection fraction (HFNEF). Reduced EF and i...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Edvardsen T,Helle-Valle T,Smiseth OA

    更新日期:2006-11-01 00:00:00

  • Functional anatomy and pathophysiologic principles in mitral regurgitation: Non-invasive assessment.

    abstract::Mitral regurgitation (MR) is the most prevalent cause of valvular heart disease (VHD) in western countries. In the Euro Heart Survey on VHD, MR was the second most common heart VHD requiring surgery. It is also the most common form of VHD in community and population-based studies from the United States. The categoriza...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Maréchaux S,Illman JE,Huynh J,Michelena HI,Nkomo VT,Tribouilloy C

    更新日期:2017-01-01 00:00:00

  • Cardiovascular effects of ephedra alkaloids: a comprehensive review.

    abstract::The Ephedra alkaloids have received much press lately secondary to reported adverse events in those using whole extracts as "dietary supplements" for weight loss or athletic performance enhancement. These reports are troubling given the increasing use of these supplements by the general public. We reviewed the availab...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Andraws R,Chawla P,Brown DL

    更新日期:2005-01-01 00:00:00

  • Diagnosis and treatment of high density lipoprotein deficiency.

    abstract::Low serum high density lipoprotein cholesterol level (HDL-C) <40 mg/dL in men and <50 mg/dL in women is a significant independent risk factor for cardiovascular disease (CVD), and is often observed in patients with hypertriglyceridemia, obesity, insulin resistance, and diabetes. Patients with marked deficiency of HDL-...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Schaefer EJ,Anthanont P,Diffenderfer MR,Polisecki E,Asztalos BF

    更新日期:2016-01-01 00:00:00

  • Reducing infarct size in the setting of acute myocardial infarction.

    abstract::Acute myocardial infarction is caused by coronary occlusion, and the mainstay of treatment has become reperfusion by either coronary angioplasty with possible stenting or surgical bypass grafting. Unfortunately, reperfusion can seldom be done soon enough to prevent infarction. Thus, the search for effective cardioprot...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Downey JM,Cohen MV

    更新日期:2006-03-01 00:00:00

  • Contrast agent--associated nephrotoxicity.

    abstract::Radiocontrast media can lead to a reversible form of acute renal failure that begins soon after the contrast dye administration and generally is benign. Contrast media accounts for 10% of all causes of hospital-acquired acute renal failure and represents the third leading cause of in-hospital renal function deteriorat...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Briguori C,Tavano D,Colombo A

    更新日期:2003-05-01 00:00:00

  • Influence of Holter monitor and electrophysiologic study methods and efficacy criteria on the outcome of patients with ventricular tachycardia and ventricular fibrillation in the ESVEM trial.

    abstract::Because not all laboratories use the monitoring and stimulation protocols used in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial, we reanalyzed the ESVEM patients' data using alternative, commonly used Holter monitor (HM) and programmed stimulation efficacy criteria to determine if d...

    journal_title:Progress in cardiovascular diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Reiffel JA,Reiter MJ,Freedman RA,Mann D,Huang SK,Hahn E,Hartz V,Mason J,ESVEM Investigators.

    更新日期:1996-03-01 00:00:00

  • Multimodality imaging in bicuspid aortic valve.

    abstract::Bicuspid aortic valve (BAV) patients are at increased risk of valve dysfunction and ascending aorta aneurysm. Imaging techniques are essential to establish diagnosis, identify complications and indicate surgical treatment. Transthoracic echocardiography (TTE) is the imaging technique of choice to diagnose BAV, valve m...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Galian-Gay L,Rodríguez-Palomares J,Guala A,Michelena HI,Evangelista A

    更新日期:2020-01-01 00:00:00

  • Evaluation of suspected right ventricular pathology in the athlete.

    abstract::Rigorous training remodels the heart of elite endurance athletes to produce the phenotype of the "athlete's heart." This remodeling, which advantages cardiac performance, creates challenges in the diagnosis of cardiac disorders within this population. This is particularly so for right ventricular pathologies because o...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Sniderman JD,Sado DM,Sniderman AD,McKenna WJ

    更新日期:2012-03-01 00:00:00

  • Natural history of thoracic aortic aneurysms: size matters, plus moving beyond size.

    abstract::Thoracic aortic aneurysms (TAAs) are a prevalent and deadly disease that, without diagnosis and treatment, eventuates in life-threatening aortic dissection or rupture. While TAAs normally grow in an indolent manner, once a certain size (a "hinge point") is reached, the risk of dissection, rupture, and death increases ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Chau KH,Elefteriades JA

    更新日期:2013-07-01 00:00:00

  • Cardiac imaging in the geriatric population: what do we think we know, and what do we need to learn?

    abstract::Cardiac imaging plays an important role in coronary artery disease (CAD), congestive heart failure (HF) and valvular heart disease (VHD) in the elderly. Imaging defines the structure and function of the cardiac system, refining the understanding of patients' anatomy and physiology and informing a host of clinical care...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Mehta N,Chokshi NP,Kirkpatrick JN

    更新日期:2014-09-01 00:00:00

  • Stem cells and their potential in cell-based cardiac therapies.

    abstract::Stem cells are potential agents for the treatment of myocardial infarcts among other heart diseases. Over the past decade, the scientific community has extensively used a wide variety of cells and examined their capacity to both regenerate the infarcted myocardium and improve functionally the diseased hearts. Some of ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Christoforou N,Gearhart JD

    更新日期:2007-05-01 00:00:00

  • Global health assistance for chronic illness: a look at the practical.

    abstract::The changing pattern of disease in the developing world calls for a change in the structure, goals, and personnel of global health assistance. Chronic diseases are now the dominant threat to health and are becoming a challenge to economic advancement in developing economies. Because confronting these diseases, heart d...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Greenberg H,Raymond SU,Leeder SR

    更新日期:2008-07-01 00:00:00

  • Myocardial perfusion imaging using contrast echocardiography.

    abstract::Microbubbles are an excellent intravascular tracer, and both the rate of myocardial opacification (analogous to coronary microvascular perfusion) and contrast intensity (analogous to myocardial blood volume) provide unique insights into myocardial perfusion. A strong evidence base has been accumulated to show comparab...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Pathan F,Marwick TH

    更新日期:2015-05-01 00:00:00

  • Acute mountain sickness: pathophysiology, prevention, and treatment.

    abstract::Barometric pressure falls with increasing altitude and consequently there is a reduction in the partial pressure of oxygen resulting in a hypoxic challenge to any individual ascending to altitude. A spectrum of high altitude illnesses can occur when the hypoxic stress outstrips the subject's ability to acclimatize. Ac...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Imray C,Wright A,Subudhi A,Roach R

    更新日期:2010-05-01 00:00:00

  • Exercise in valvular heart disease: risks and benefits.

    abstract::Valvular heart disease (VHD) carries documented risks for active individuals. At the same time, many individuals with intermediate degrees of valve disease can safely exercise and even participate in competitive athletics. Unfortunately for clinicians caring for these patients, data are scarce. Understanding the patho...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Parker MW,Thompson PD

    更新日期:2011-05-01 00:00:00

  • The cellular ionic basis of hypertension and allied clinical conditions.

    abstract::Two central concepts of human hypertensive disease remain poorly understood: (1) elevated blood pressure as merely one component of an underlying systemic condition, characterized by multiple defects in diverse tissues (eg, "Syndrome X"), and (2) the heterogeneity of hypertension, in which different and even opposite ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Resnick L

    更新日期:1999-07-01 00:00:00

  • Myocardial infarction and risk region relationships: evaluation by direct and noninvasive methods.

    abstract::Optimal quantitation of myocardial infarction requires resolution of the three-dimensional geometry of the ischemic region at a time that progression of tissue necrosis has been completed and can be sharply delineated from noninfarcted myocardium but before significant remodeling of the ventricular chamber. Although t...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Cobb FR,Chu A

    更新日期:1988-03-01 00:00:00