Abstract:
:Cre/loxP recombination is a powerful strategy widely used for in vivo conditional gene targeting. This technique has made possible many important discoveries of gene function in normal and disease biology. However, due to the transgenic nature of most Cre mouse strains undesired phenotypes occasionally occur in Cre mice. Here we report skeletal defects in Osterix-Cre (Osx-Cre) transgenic mice including delayed calvarial ossification and fracture calluses at multiple skeletal sites. These data suggest that Osx-Cre containing controls should be used for both in vivo and in vitro skeletal analyses of conditional knockout mice generated with this Osx-Cre mouse strain.
journal_name
Transgenic Resjournal_title
Transgenic researchauthors
Huang W,Olsen BRdoi
10.1007/s11248-014-9828-6subject
Has Abstractpub_date
2015-02-01 00:00:00pages
167-72issue
1eissn
0962-8819issn
1573-9368journal_volume
24pub_type
杂志文章abstract::Neprilysin (NEP) is a cell surface metallopeptidase found in many tissues. Based mostly on pharmacological manipulations, NEP has been thought to protect blood vessels from plasma extravasation. We have suggested that NEP may protect against pulmonary vascular injury. However, these prior studies did not utilize mice ...
journal_title:Transgenic research
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journal_title:Transgenic research
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journal_title:Transgenic research
pub_type: 杂志文章,评审
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journal_title:Transgenic research
pub_type: 杂志文章
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journal_title:Transgenic research
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journal_title:Transgenic research
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doi:10.1007/s11248-014-9821-0
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journal_title:Transgenic research
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journal_title:Transgenic research
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journal_title:Transgenic research
pub_type: 杂志文章
doi:10.1007/s11248-006-9044-0
更新日期:2007-08-01 00:00:00
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journal_title:Transgenic research
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journal_title:Transgenic research
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
abstract::We generated a transgenic (Tg) mouse line expressing Cre recombinase under the control of the Gpr88 promoter within a bacterial artificial chromosome clone. We crossed the established Tg mice with reporter mice (CAG-CAT-Z Tg), which express Escherichia coli lacZ in response to Cre-mediated excision of the loxP-flanked...
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pub_type: 杂志文章
doi:10.1007/s11248-013-9711-x
更新日期:2013-12-01 00:00:00
abstract::SULT2A8 is a male-predominant and liver-specific mouse cytosolic sulfotransferase (SULT) that sulfonates 7α-hydroxyl (7α-OH) bile acids in vitro. Sulfonation regulates bile acid homeostasis, which in turn regulates cholesterol and energy metabolism. Using the Sult2a8-heterozygous (HT) mouse model created earlier in ou...
journal_title:Transgenic research
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更新日期:2020-12-01 00:00:00
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journal_title:Transgenic research
pub_type: 杂志文章
doi:10.1007/s11248-007-9101-3
更新日期:2008-04-01 00:00:00
abstract::Watermelon, an important fruit crop worldwide, is prone to attack by several viruses that often results in destructive yield loss. To develop a transgenic watermelon resistant to multiple virus infection, a single chimeric transgene comprising a silencer DNA from the partial N gene of Watermelon silver mottle virus (W...
journal_title:Transgenic research
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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doi:10.1007/s11248-010-9420-7
更新日期:2011-04-01 00:00:00
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journal_title:Transgenic research
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doi:10.1007/s11248-017-0039-9
更新日期:2017-12-01 00:00:00
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journal_title:Transgenic research
pub_type: 杂志文章
doi:10.1007/s11248-006-9054-y
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Transgenic research
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更新日期:1993-03-01 00:00:00
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journal_title:Transgenic research
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journal_title:Transgenic research
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Transgenic research
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journal_title:Transgenic research
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更新日期:2012-06-01 00:00:00
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journal_title:Transgenic research
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更新日期:2004-10-01 00:00:00
abstract::Embryonic stem (ES) cells provide a unique tool for cell-mediated gene transfer and targeted gene mutations due to the possibility of in vitro selection of desired genotypes. When selected cells contribute to the germ line in chimaeric embryos, transgenic animals may be generated with modified genetic traits. Though t...
journal_title:Transgenic research
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