Ranitidine compared with cimetidine in the short-term healing of duodenal ulcer.

Abstract:

:The efficacy of ranitidine (150 mg twice daily) and cimetidine (200 mg three times daily and 400 mg at night) in the short-term healing of duodenal ulcer has been assessed in a randomized controlled trial involving 106 patients. There were 3 drop-outs. Forty-two out of 53 patients (79%) treated with ranitidine had healed ulcers at 4 weeks compared with 37 out of 50 treated with cimetidine (74%). This difference is not significant. At 8 weeks the healing rate for ranitidine (98%) was significantly greater than that for cimetidine (86%) (P less than 0.05). There was no significant difference in healing rates between men and women and between smokers and non-smokers. Side effects were not a problem with either drug. There were no differences of clinical significance between laboratory values in the two treatment groups, although a minor increase in mean creatinine levels occurred in the cimetidine-treated group.

journal_name

Postgrad Med J

authors

Lee FI,Fielding JD,Costello FT

doi

10.1136/pgmj.59.688.88

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

88-92

issue

688

eissn

0032-5473

issn

1469-0756

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章

    doi:

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    pub_type: 杂志文章

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    更新日期:1979-06-01 00:00:00

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    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

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    更新日期:2004-05-01 00:00:00

  • An audit of "do not attempt resuscitation" decisions in two district general hospitals: do current guidelines need changing?

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    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究

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  • Peyronie's disease in a district general hospital.

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