Ontogenesis of autonomic receptors in detrusor muscle and bladder sphincter of human fetus.

Abstract:

:An investigation was made of the distribution and the ontogenesis of various types of receptors in the bladder detrusor muscles and sphincter isolated from human fetuses at different stages of pregnancy. Cholinergic receptors appear very early in the fetal urinary bladder since contractile responses to bethanechol, competitively blocked by atropine, are observed in detrusor muscle preparations at three months and in the sphincter at four months. Later on, the density of cholinergic receptors increases in the detrusor muscle whereas there is a progressive reduction in the sphincter.

journal_name

Urology

journal_title

Urology

authors

Mitolo-Chieppa D,Schönauer S,Grasso G,Cicinelli E,Carratú MR

doi

10.1016/0090-4295(83)90201-7

subject

Has Abstract

pub_date

1983-06-01 00:00:00

pages

599-603

issue

6

eissn

0090-4295

issn

1527-9995

pii

0090-4295(83)90201-7

journal_volume

21

pub_type

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