Lymphocyte homing antagonists in the treatment of inflammatory bowel diseases.

Abstract:

:Lymphocyte homing antagonists represent promising therapeutic agents for the treatment of idiopathic inflammatory bowel disease (IBD). Several critical molecules involved in the recruitment of inflammatory cells in the intestine, including integrins and chemokine receptors, have been successfully targeted for the treatment of IBD. These agents have shown great promise for the induction and maintenance of remission for both Crohn disease and ulcerative colitis. This article discusses currently approved prototypic agents for the treatment of IBD (natalizumab, anti-α4 integrin; vedolizumab, anti-α4β7 integrin), and several other agents in the same class currently under development.

authors

Saruta M,Papadakis KA

doi

10.1016/j.gtc.2014.05.012

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

581-601

issue

3

eissn

0889-8553

issn

1558-1942

pii

S0889-8553(14)00069-7

journal_volume

43

pub_type

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