Abstract:
:Lymphocyte homing antagonists represent promising therapeutic agents for the treatment of idiopathic inflammatory bowel disease (IBD). Several critical molecules involved in the recruitment of inflammatory cells in the intestine, including integrins and chemokine receptors, have been successfully targeted for the treatment of IBD. These agents have shown great promise for the induction and maintenance of remission for both Crohn disease and ulcerative colitis. This article discusses currently approved prototypic agents for the treatment of IBD (natalizumab, anti-α4 integrin; vedolizumab, anti-α4β7 integrin), and several other agents in the same class currently under development.
journal_name
Gastroenterol Clin North Amjournal_title
Gastroenterology clinics of North Americaauthors
Saruta M,Papadakis KAdoi
10.1016/j.gtc.2014.05.012subject
Has Abstractpub_date
2014-09-01 00:00:00pages
581-601issue
3eissn
0889-8553issn
1558-1942pii
S0889-8553(14)00069-7journal_volume
43pub_type
杂志文章,评审abstract::The health care burden of hepatitis C virus (HCV) infection is projected to continue to increase over the next two decades, so improving the efficacy of anti-HCV therapy has the potential to significantly affect health care utilization associated with the disease. Adherence to standard combination therapy and maintain...
journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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