Immunology of inflammatory bowel disease and molecular targets for biologics.

abstract：:Biotherapeutic agents offer unique advantages over traditional treatments for infectious diarrhea, and several have been shown to be effective (Table 4). These therapeutic microbial agents are most effective in types of infectious diseases that are associated with a disruption of the normal intestinal microecology (e....

journal_title：Gastroenterology clinics of North America

authors： Elmer GW,McFarland LV

更新日期：2001-09-01 00:00:00

abstract：:Corticosteroids are a nonspecific immune modulator used in the treatment of ulcerative colitis. Topical and systemic forms of corticosteroids have been shown to be effective in induction of clinical remission and remain first-line therapy for acute severe ulcerative colitis. A large proportion of patients experience a...

journal_title：Gastroenterology clinics of North America

authors： George LA,Cross RK

更新日期：2020-12-01 00:00:00

abstract：:If one reviews the literature with zeal, it is increasingly apparent that few organs escape recruitment when IBD is chronic or progressive. Insights into mucosal pathophysiology have helped with understanding the more frequent extraintestinal manifestations, but the mechanisms attendant to the development of less comm...

journal_title：Gastroenterology clinics of North America

authors： Levine JB,Lukawski-Trubish D

更新日期：1995-09-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is defined by either subjective complaints indicative of problematic gastroesophageal reflux or objective complications directly attributable to reflux. Studies focused on GERD-related symptoms suggest a worldwide increase in prevalence of approximately 4% per year. Epidemiologic...

journal_title：Gastroenterology clinics of North America

authors： Pandolfino JE,Kwiatek MA,Kahrilas PJ

更新日期：2008-12-01 00:00:00

abstract：:Pediatric patients with inflammatory bowel disease (IBD) stand to benefit from quality improvement (QI) due to the chronic nature of the disease, frequent interaction with the health care system, and exposure to high-risk treatments. The use of QI in health care has led to significant improvements in quality and relia...

journal_title：Gastroenterology clinics of North America

authors： Egberg MD,Kappelman MD,Gulati AS

更新日期：2018-12-01 00:00:00

abstract：:Focal liver lesions occur commonly and with varying histology, each requiring radically different management. There are a multitude of imaging modalities currently being used for detecting and characterizing focal liver neoplasms. The primary modalities include ultrasonography, computed tomography (CT), magnetic reson...

journal_title：Gastroenterology clinics of North America

authors： Harisinghani MG,Hahn PF

更新日期：2002-09-01 00:00:00

abstract：:The development of colorectal neoplasia originates from normal colonic mucosa, progresses to the adenomatous polyp, and later may evolve into carcinoma. This procession of histologic change can be defined by a series of successive waves of clonal expansion that contain certain genetic alterations. These genetic altera...

journal_title：Gastroenterology clinics of North America

authors： Carethers JM

更新日期：1996-12-01 00:00:00

abstract：:The effect of Helicobacter pylori eradication treatment needs confirmation in patients with persistent symptoms and in those with complicated peptic ulcer. Endoscopic surveillance after eradication is needed in patients with advanced premalignant gastric lesions, previous early gastric cancer, gastric MALT lymphoma, a...

journal_title：Gastroenterology clinics of North America

authors： Kuipers EJ

更新日期：2015-09-01 00:00:00

abstract：:Because there are no reliable biological or laboratory markers associated with the condition, the diagnosis of irritable bowel syndrome(IBS) is based on patient descriptions of common symptoms such as abdominal pain accompanied by changes in stool form or frequency and associated symptoms such as bloating and distensi...

journal_title：Gastroenterology clinics of North America

authors： Cash BD,Chey WD

更新日期：2005-06-01 00:00:00

abstract：:Arguments proposed in this article may explain why a subgroup of patients, having so-called "functional heartburn," does not respond to acid inhibition therapy [19,20]. It is highly likely that acid is not the cause of heartburn in this group of subjects. These conclusions are supported further by observations of Wien...

journal_title：Gastroenterology clinics of North America

authors： Steinbach J,Fass R,Mittal RK

更新日期：2002-12-01 00:00:00

abstract：:Biologics are a primary focus for research and development of new treatments for IBD and other immune disorders. CDER, which is a branch of the FDA, oversees most of the biologics that are being used or tested for IBD, and it regulates nonbiologic medications for IBD. The approval process for most biologics for IBD is...

journal_title：Gastroenterology clinics of North America

authors： Tremaine WJ

更新日期：2006-12-01 00:00:00

abstract：:This article reviews the role of therapeutic endoscopy in the diagnosis and treatment of nonvariceal upper and lower gastrointestinal (GI) hemorrhage. The initial approach to patients with GI bleeding is reviewed. Endoscopic treatment of various stigmata of recent peptic ulcer hemorrhage is discussed in detail. Manage...

journal_title：Gastroenterology clinics of North America

authors： Savides TJ,Jensen DM

更新日期：2000-06-01 00:00:00

abstract：:Gastric cancers are a histologically heterogenous group of neoplasms arising from unique epidemiologic and molecular backgrounds. There is accumulating evidence that the intestinal type of gastric adenocarcinoma develops through a multistep process beginning with chronic gastritis triggered primarily by Helicobacter p...

journal_title：Gastroenterology clinics of North America

authors： Yakirevich E,Resnick MB

更新日期：2013-06-01 00:00:00

abstract：:Diverticulitis represents a spectrum of clinical entities ranging from minimal pericolitis in the adjacent mesentery to uncontrolled intra-abdominal sepsis and septic shock. The presentation most often described is left lower quadrant abdominal pain, fever, chills, and left lower quadrant tenderness associated with a ...

journal_title：Gastroenterology clinics of North America

authors： Pohlman T

更新日期：1988-06-01 00:00:00

abstract：:Bile supersaturation is necessary for cholesterol gallstones to form. Not all people with supersaturated bile form gallstones, however, and additional factors must be present. The role of pronucleating substances has been extensively studied. Of these, proteins, especially mucin, are best understood. Mucin is secreted...

journal_title：Gastroenterology clinics of North America

authors： Ko CW,Lee SP

更新日期：1999-03-01 00:00:00

abstract：:Managed care organizations and their products will continue to change in response to consumer demands, competitive pressures, and regulatory requirements. Providers who gain an understanding of the world managed care organizations live in can also expect to influence these organizations for mutual benefit. Just as man...

journal_title：Gastroenterology clinics of North America

authors： Behnke LM

更新日期：1997-12-01 00:00:00

abstract：:Diarrhea is a common clinical feature of inflammatory bowel diseases and may be accompanied by abdominal pain, urgency, and fecal incontinence. The pathophysiology of diarrhea in these diseases is complex, but defective absorption of salt and water by the inflamed bowel is the most important mechanism involved. In add...

journal_title：Gastroenterology clinics of North America

authors： Wenzl HH

更新日期：2012-09-01 00:00:00

abstract：:Nutritional strategies have been explored as primary or adjunct therapies for inflammatory bowel disease (IBD). Exclusive enteral nutrition is effective for the induction of remission in Crohn disease and is recommended as a first-line therapy for children. Dietary strategies focus on adjusting the ratio of consumed n...

journal_title：Gastroenterology clinics of North America

authors： Limketkai BN,Wolf A,Parian AM

更新日期：2018-03-01 00:00:00

abstract：:Colorectal cancer (CRC) develops from a dysplastic precursor lesion, regardless of whether it arises sporadically, in the setting of high-risk hereditary conditions, or in the context of chronic inflammation like inflammatory bowel disease (IBD). This review focuses on the molecular alterations associated with CRC pat...

journal_title：Gastroenterology clinics of North America

authors： Itzkowitz SH

更新日期：2006-09-01 00:00:00

abstract：:In conclusion, H. pylori infection can be detected by a variety of methods. The simplest, least expensive noninvasive method is serologic testing. Unfortunately, positive serology can only presume current infection. Urea breath testing is also noninvasive and is positive only in the setting of current infection; it is...

journal_title：Gastroenterology clinics of North America

authors： Brown KE,Peura DA

更新日期：1993-03-01 00:00:00

abstract：:Three (author's standard) or five biopsy specimens (two antral, two corpus, one incisura) as suggested by the Sydney system (original and revised version) [figure: see text] correctly separate infected mucosa from uninfected mucosa. No combination identified correctly the presence of intestinal metaplasia to be consid...

journal_title：Gastroenterology clinics of North America

authors： el-Zimaity HM

更新日期：2000-12-01 00:00:00

abstract：:Anal cancer is rare and this helps to explain why anal pre-neoplastic conditions are poorly understood, especially with regard to their natural history and management. Anal intraepithelial neoplasia is closely linked to human papillomavirus infection and is particularly common in homosexuals and in immunosuppressed pa...

journal_title：Gastroenterology clinics of North America

authors： Shepherd NA

更新日期：2007-12-01 00:00:00

abstract：:BA is a rare disease of unclear etiology; nevertheless, its impact in the field of pediatric hepatology is significant. It is the most common surgically correctable cause of neonatal cholestasis and is the most common pediatric disease referred for liver transplantation. Little progress has been made with regard to im...

journal_title：Gastroenterology clinics of North America

authors： Haber BA,Russo P

更新日期：2003-09-01 00:00:00

abstract：:HCV in the East is a complex scenario with prevalence rates of 0.5% to as high as 4.7%, and variable distributions of genotypes, with a dominance of genotype 1b in East Asia, genotype 3 in South Asia and South East Asia, and genotype 6 in Indochina. Approvals for the new oral directing antiviral agents (DAAs), in the ...

journal_title：Gastroenterology clinics of North America

authors： Dan YY,Lim SG

更新日期：2015-12-01 00:00:00

abstract：:Radionuclide studies of the upper gastrointestinal tract have been useful in many gastrointestinal disorders. However, the literature relating to radionuclide techniques in morbid obesity is limited and, at times, controversial. It is hoped that this brief review will stimulate interest in the use of tracer techniques...

journal_title：Gastroenterology clinics of North America

authors： DeRogatis AJ

更新日期：1987-06-01 00:00:00

abstract：:Precursor lesions in the GIT include flat dysplasias, adenomas, dysplasia superimposed on nonneoplastic polyps, endocrine cell dysplasia, ACF, and condyloma accuminatum. Interobserver variability can be a problem in reporting dysplasia, and ancillary techniques including flow cytometry, image analysis, proliferation m...

journal_title：Gastroenterology clinics of North America

authors： Haber MM

更新日期：2002-06-01 00:00:00

abstract：:In patients with Crohn's disease on biologic medications, the use of therapeutic drug monitoring leads to a personalized approach to optimize treatment. Using an algorithmic approach, measurement of drug concentrations and anti-drug antibodies can be used to improve treatment outcomes. Therapeutic drug concentrations ...

journal_title：Gastroenterology clinics of North America

authors： Heron V,Afif W

更新日期：2017-09-01 00:00:00

abstract：:This brief review summarizes the physiology and pharmacology of eicosanoids and describes how they have been tested for possible application in liver disease and transplantation. The objective is to trace the stepwise application from the laboratory to the bedside. Although many questions remain to be answered, the ob...

journal_title：Gastroenterology clinics of North America

authors： Ruwart MJ,Henley KS

更新日期：1996-06-01 00:00:00

abstract：:Foreign body ingestion is a common occurrence in children and in specific high-risk groups of adults such as those with underlying esophageal disease, prisoners, the mentally retarded, and those with psychiatric illnesses. Although most foreign bodies pass through the gastrointestinal tract without difficulty, sharp, ...

journal_title：Gastroenterology clinics of North America

authors： Brady PG

更新日期：1991-12-01 00:00:00

abstract：:Therapeutic gastrointestinal endoscopy has a much greater risk of inducing gastrointestinal hemorrhage than diagnostic endoscopy. For example, colonoscopic polypectomy has a risk of approximately 1.6% of inducing bleeding, compared with a risk of approximately 0.02% for diagnostic colonoscopy. Higher-risk procedures i...

journal_title：Gastroenterology clinics of North America

authors： Cappell MS,Abdullah M

更新日期：2000-03-01 00:00:00