Antibiotic prevention of infections complicating radical abdominal hysterectomy.

Abstract:

:In this randomized, double-blind study, the effectiveness of a single-agent prophylactic antibiotic in reducing infections after radical abdominal hysterectomy with pelvic and para-aortic lymphadenectomy was compared with a placebo. A total of 12 doses of cefoxitin (2g) or placebo were given to 70 patients, starting the evening before surgery. Because of tumor spread beyond the cervix, radical hysterectomy was not performed in 17 patients who were, therefore, excluded from the study. Analysis of 53 patients who completed the study revealed that 15% of cefoxitin patients had surgical site-related infections compared with 52% of placebo patients (P = .005). Significant differences between the groups were also observed in nonsurgical site-related infections (23 versus 48%), overall morbidity (58 versus 89%), and the need for additional antibiotic therapy (38 versus 67%). Socioeconomic status was a significant risk factor with 57% of staff patients demonstrating increased site-related infections as compared with 17% of private patients (P = .002). No clinically significant side effects were observed. The authors recommend the use of antibiotic prophylaxis in patients undergoing radical abdominal hysterectomy for gynecologic malignancies.

journal_name

Obstet Gynecol

authors

Sevin BU,Ramos R,Lichtinger M,Girtanner RE,Averette HE

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

539-45

issue

4

eissn

0029-7844

issn

1873-233X

journal_volume

64

pub_type

临床试验,杂志文章
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    doi:

    authors: Quagliarello J,Steinetz BG,Weiss G

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    doi:

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  • Planned vaginal delivery following cesarean section.

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    doi:

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  • Blood transfusion complications: leukoagglutinin reactions.

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    doi:

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    pub_type: 杂志文章

    doi:

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    pub_type: 杂志文章

    doi:

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    更新日期:1992-02-01 00:00:00

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    doi:

    authors: Faustin D,Minkoff H,Schaffer R,Crombleholme W,Schwarz R

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    doi:

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  • Carcinoma in situ of the vagina. A study and review.

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  • Orogenital sex as a cause of nonfatal air embolism in pregnancy.

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  • Single-probe spectrophotometry in the assessment of fetal oxygenation.

    abstract::Six sheep fetuses were monitored with a single-probe tissue spectrophotometer. This spectrophotometer provides continuous digital output of the index of hemoglobin that is saturated with oxygen. To vary the fetal pO2, each maternal ewe was given room air, 100% oxygen, 12% oxygen, and 100% nitrogen via rebreathing bag....

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    authors: Egley CC,Seeds JW,Cefalo RC

    更新日期:1987-11-01 00:00:00

  • Sexual function in women with uterovaginal prolapse and urinary incontinence.

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  • Recurrence of Preterm Birth and Early Term Birth.

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    pub_type: 杂志文章

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  • Prenatal imaging: ultrasonography and magnetic resonance imaging.

    abstract::The Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop on September 18-19, 2006, to summarize the available evidence on the role and performance of current fetal imaging technology and to establish a research agenda. Ultrasonography is the imaging modality of choice for pre...

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    更新日期:2008-07-01 00:00:00

  • Transcervical Foley catheter with and without extraamniotic saline infusion for labor induction: a randomized controlled trial.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

    doi:

    authors: Haning RV Jr,Austin CW,Carlson IH,Kuzma DL,Zweibel WJ

    更新日期:1985-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2012-06-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Nuovo GJ,Blanco JS,Leipzig S,Smith D

    更新日期:1990-06-01 00:00:00

  • A new method of promoting fertility.

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    pub_type: 杂志文章

    doi:

    authors: Amelar RD,Dubin L

    更新日期:1975-01-01 00:00:00

  • Clinical significance of urethral instability.

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    pub_type: 杂志文章

    doi:

    authors: Weil A,Miège B,Rottenberg R,Krauer F

    更新日期:1986-07-01 00:00:00

  • Revisiting the fetal loss rate after second-trimester genetic amniocentesis: a single center's 16-year experience.

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