Abstract:
:Transient receptor potential (TRP) cation channels represent a large and diverse family of ion channels that act as important transducers of sensory information. The Melastatin subfamily member TRPM7 has garnered much interest due to its functional kinase domain; a unique feature among ion channels. TRPM7 primarily conducts Ca(2+) and Mg(2+) and its activity is regulated by intracellular Mg(2+), phospholipase C-mediated signaling and mechanical cues. A growing number of studies emphasize a regulatory role for TRPM7 in proliferation and cell survival as well as cytoskeletal reorganization during adhesion and migration. Knockout approaches in animal models have revealed that TRPM7 significantly contributes to embryonic development and organogenesis. In addition, a role for TRPM7 to the pathophysiology of several diseases has become evident in recent years. Here, we discuss how recent insights have contributed to our understanding of TRPM7 function and regulation in health and disease.
journal_name
Eur J Cell Bioljournal_title
European journal of cell biologyauthors
Visser D,Middelbeek J,van Leeuwen FN,Jalink Kdoi
10.1016/j.ejcb.2014.07.001subject
Has Abstractpub_date
2014-10-01 00:00:00pages
455-65issue
10-12eissn
0171-9335issn
1618-1298pii
S0171-9335(14)00066-1journal_volume
93pub_type
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
pub_type: 杂志文章,评审
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
pub_type: 杂志文章,评审
doi:10.1016/j.ejcb.2006.05.009
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journal_title:European journal of cell biology
pub_type: 杂志文章
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更新日期:1988-08-01 00:00:00
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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doi:10.1016/j.ejcb.2012.06.004
更新日期:2012-10-01 00:00:00
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journal_title:European journal of cell biology
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
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journal_title:European journal of cell biology
pub_type: 杂志文章
doi:10.1016/S0171-9335(99)80053-3
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journal_title:European journal of cell biology
pub_type: 杂志文章
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更新日期:1984-05-01 00:00:00
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journal_title:European journal of cell biology
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更新日期:1992-10-01 00:00:00
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journal_title:European journal of cell biology
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
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journal_title:European journal of cell biology
pub_type: 杂志文章
doi:
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journal_title:European journal of cell biology
pub_type: 杂志文章
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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