Abstract:
:Poly(dA-dT).poly(dA-dT) can adopt the B- and D- forms in the fibrous state. Theoretical energy calculations and fiber diffraction analyses suggest that there can be three structural models of poly(dA-dT).poly(dA-dT) in each of these two forms viz right and left-handed Watson Crick models and left-handed Hoogsteen--a total of six possible models. Fiber data for the polymer in the B- or the D-form or energy calculations cannot distinguish any one model from the other. However, a comparison of observed proton chemical shifts with the theoretically computed ones and the NOE studies on exchangeable and nonexchangeable protons suggest that poly(dA-dT).poly(dA-dT) in low salt solution exists predominantly in the left-handed B-conformation.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Gupta G,Sarma MH,Dhingra MM,Sarma RH,Rajagopalan M,Sasisekharan Vdoi
10.1080/07391102.1983.10507450subject
Has Abstractpub_date
1983-10-01 00:00:00pages
395-416issue
2eissn
0739-1102issn
1538-0254journal_volume
1pub_type
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