Binding site specificity of gamma-radiation-induced crosslinking between phenylalanine and a phenylalanine-containing tetrapeptide.

abstract：:Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in Sfpi1 on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of the Sfpi1 gene (DSG) and point mutation of the allele Sfpi1 gene (PMASG). In this study, we ...

journal_title：Radiation research

authors： Ojima M,Hirouchi T,Etani R,Ariyoshi K,Fujishima Y,Kai M

更新日期：2019-12-01 00:00:00

abstract：:Monte Carlo simulations are used in the development of a nanotechnology-based multi-pixel beam array small animal microirradiation system. The microirradiation system uses carbon nanotube field emission technology to generate arrays of individually controllable X-ray pixel beams that electronically form irregular irra...

journal_title：Radiation research

authors： Schreiber EC,Chang SX

更新日期：2009-03-01 00:00:00

abstract：:The survival of synchronous G1 or asynchronous Chinese hamster ovary cells in vitro to heat treatment may depend on the cellular population density at the time of heating and/or as the cells are cultured after heating. The addition of lethally irradiated feeder cells may increase survival at 10(-3) by as much as 10- t...

journal_title：Radiation research

authors： Highfield DP,Holahan EV,Holahan PK,Dewey WC

更新日期：1984-01-01 00:00:00

abstract：:Previous studies showed that a 6-week pretreatment of rats with testosterone plus estradiol enhanced the recovery of spermatogenesis 9 weeks after gamma irradiation, resulting in a dose-modifying factor (DMF) of about 2. To test whether the effect of the hormone treatment was mediated through changes in oxygen tension...

journal_title：Radiation research

authors： Wilson G,Kangasniemi M,Meistrich ML

更新日期：1999-07-01 00:00:00

abstract：:The radiation dose received by crew members in interplanetary space is influenced by the stage of the solar cycle. Using the recently developed models of the galactic cosmic radiation (GCR) environment and the energy-dependent radiation transport code, we have calculated the dose at 0 and 5 cm water depth; using a com...

journal_title：Radiation research

authors： Badhwar GD,Cucinotta FA,O'Neill PM

更新日期：1994-05-01 00:00:00

abstract：:The relationship between binucleate cell formation and the loss of colony-forming ability was examined in several cultured mammalian cell lines irradiated with X rays. The maximum fraction of binucleate cells after X irradiation increased dose-dependently within the range in which reproductive cell death might predomi...

journal_title：Radiation research

authors： Sasaki H,Yoshinaga H,Kura S

更新日期：1986-12-01 00:00:00

abstract：:It has been shown that several X-ray-sensitive Chinese hamster cell mutants defective in repair of DNA double-strand breaks (DSBs) are also impaired in the process of V(D)J recombination. The hamster mutants with this phenotype represent three distinct complementation groups, represented by the xrs series, XR-1 and V-...

journal_title：Radiation research

authors： Zdzienicka MZ,Jongmans W,Oshimura M,Priestley A,Whitmore GF,Jeggo PA

更新日期：1995-09-01 00:00:00

abstract：:It was reported by others that hands-free accessories increase the absorption of RF energy in a human head compared to a handset alone. The results of this study show that the opposite is observed when proper dosimetric methods are employed. It is pointed out that for correct estimation of the exposure level it is nec...

journal_title：Radiation research

authors： Bit-Babik G,Chou CK,Faraone A,Gessner A,Kanda M,Balzano Q

更新日期：2003-04-01 00:00:00

abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...

journal_title：Radiation research

authors： Maeda J,Bell JJ,Genet SC,Fujii Y,Genet MD,Brents CA,Genik PC,Kato TA

更新日期：2014-10-01 00:00:00

abstract：:Human keratinocytes show a bystander effect when exposed to low doses of low-LET radiation. In this paper, data are presented showing a method of correcting the overall survival curve to enable analysis of the relative contributions of the bystander effect and the effect attributable to direct interaction of the radia...

journal_title：Radiation research

authors： Seymour CB,Mothersill C

更新日期：2000-05-01 00:00:00

abstract：:To examine more fully the nature of chromosomal radiosensitivity in ataxia telangiectasia (AT) cells, we employed 24-color combinatorial painting to visualize 137Cs gamma-ray-induced chromosome-type aberrations in cells of two AT and one normal primary human fibroblast strains irradiated in log-phase growth. As a meas...

journal_title：Radiation research

authors： Loucas BD,Cornforth MN

更新日期：2004-11-01 00:00:00

abstract：:In an attempt to elucidate mechanisms underlying the variation in radiosensitivity during the cell cycle, mutations in the HPRT gene were selected with 6-thioguanine, quantified and characterized in synchronous human bladder carcinoma cells (EJ30-15) that were irradiated in G1 or S phase with 3 or 6 Gy. Synchronous ce...

journal_title：Radiation research

authors： Leonhardt EA,Trinh M,Forrester HB,Johnson RT,Dewey WC

更新日期：1997-12-01 00:00:00

abstract：:A dose of heat which renders 98% of a population of Chinese hamster ovary cells reproductively dead has no significant effect on their Na+, K+, or Mg2+ content by 28 h postheat. In contrast, the cellular Ca2+ content increases in a dose-dependent manner as observed at 22 h after heating for 15-35 min at 45 degrees C. ...

journal_title：Radiation research

authors： Vidair CA,Dewey WC

更新日期：1986-02-01 00:00:00

abstract：:In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The comparative effects of liposomal and free DTP...

journal_title：Radiation research

authors： Grémy O,Miccoli L,Lelan F,Bohand S,Cherel M,Mougin-Degraef M

更新日期：2018-05-01 00:00:00

abstract：:Previously, we described the radiation-induced (RI) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) effect as the increased MTT metabolization at the intermediate dose region after the irradiation of an MCF-7/6 cell monolayer with an X-ray dose gradient. We wondered if the cell monolayer at the inte...

journal_title：Radiation research

authors： Blockhuys S,Vanhoecke B,Smet J,De Paepe B,Van Coster R,Bracke M,De Wagter C

更新日期：2013-04-01 00:00:00

abstract：:Although conclusive evidence has been obtained for the presence of radiation-induced bystander effects, the mechanisms that trigger and regulate these processes are still largely unknown. The bystander effect may play a critical role in determining the biological effectiveness of low-dose exposures, but questions on h...

journal_title：Radiation research

authors： Schettino G,Folkard M,Michael BD,Prise KM

更新日期：2005-03-01 00:00:00

abstract：:The retention of 241Am in mice 48 h after administration by gavage is reported here. The 241Am was given to mice in the form of either 241Am nitrate or 241Am citrate. The 241Am was also injected into rats in the same form. The homogenized livers of those rats were subsequently administered by gavage to another group o...

journal_title：Radiation research

authors： Hisamatsu S,Takizawa Y

更新日期：1987-08-01 00:00:00

abstract：:Comparatively high exposures to power-frequency electric and magnetic fields produce established biological effects that are explained by accepted mechanisms and that form the basis of exposure guidelines. Lower exposures to magnetic fields (< 1 microT average in the home) are classified as "possibly carcinogenic" on ...

journal_title：Radiation research

authors： Swanson J,Kheifets L

更新日期：2006-04-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are 2.9 times more frequently induced in yeast cells exposed to sparsely ionizing 30-MeV electrons under oxic compared to anoxic conditions. The rejoining of DSBs induced under anoxic conditions was investigated under conditions allowing repair of potentially lethal damage and compared ...

journal_title：Radiation research

authors： Frankenberg-Schwager M,Frankenberg D,Harbich R

更新日期：1991-12-01 00:00:00

abstract：:The radiation environment in low-Earth orbit is a complex mixture of galactic cosmic radiation, particles of trapped belts and secondary particles generated in both the spacecraft and Earth's atmosphere. Infrequently, solar energetic particles are injected into the Earth's magnetosphere and can penetrate into low-Eart...

journal_title：Radiation research

authors： Badhwar GD

更新日期：1997-11-01 00:00:00

abstract：:It is well established that high-LET radiations efficiently induce chromosome aberrations. However, data on the effect of protons on telomere maintenance, as involved in genomic stability, are scarce and contradictory. Here we demonstrate that high-LET protons induce telomere lengthening in human primary fibroblasts a...

journal_title：Radiation research

authors： Berardinelli F,Antoccia A,Cherubini R,De Nadal V,Gerardi S,Cirrone GA,Tanzarella C,Sgura A

更新日期：2010-11-01 00:00:00

abstract：:The photodynamic properties of a second-generation photodynamic sensitizer, meta-tetra(hydroxyphenyl)chlorin (mTHPC) were studied by dye-sensitized photoinactivation (650 nm) of HT29 human adenocarcinoma cells in culture. The photocytotoxicity of mTHPC in vitro depended on the presence of molecular oxygen. A strong in...

journal_title：Radiation research

authors： Melnikova VO,Bezdetnaya LN,Potapenko AY,Guillemin F

更新日期：1999-10-01 00:00:00

abstract：:Extension of previous investigations at this laboratory regarding life shortening and tumor induction in the mouse has provided more complete dose-response information in the low dose region of X rays and neutrons. A complete observation of survival and late pathology has been carried out on over 2000 BC3F1 female mic...

journal_title：Radiation research

authors： Covelli V,Coppola M,Di Majo V,Rebessi S,Bassani B

更新日期：1988-02-01 00:00:00

abstract：:Cisplatin and binuclear rhodium (Rh2) carboxylates appear to potentiate radiation-induced killing of Salmonella typhimurium cells largely as a consequence of one-electron reduction that leads to an active radiolytic product. This conclusion is supported by results from experiments wherein the hydrated electron and the...

journal_title：Radiation research

authors： Richmond RC,Mahtani HK

更新日期：1991-07-01 00:00:00

abstract：:The well-established process of potentially lethal damage (PLD) repair enhances plateau-phase cell survival after exposure to ionizing radiation. PLD repair requires that confluent cells be incubated prior to plating for a colony-forming assay rather than being plated immediately. Enhanced double-strand break (DSB) re...

journal_title：Radiation research

authors： Igarashi K,Miura M

更新日期：2008-10-01 00:00:00

abstract：:We studied the LET and ion species dependence of the RBE for cell killing to clarify the differences in the biological effects caused by the differences in the track structure that result from the different energy depositions for different ions. Normal human skin fibroblasts were irradiated with heavy-ion beams such a...

journal_title：Radiation research

authors： Tsuruoka C,Suzuki M,Kanai T,Fujitaka K

更新日期：2005-05-01 00:00:00

abstract：:Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...

journal_title：Radiation research

authors： Latre L,Genescà A,Martín M,Ribas M,Egozcue J,Blasco MA,Tusell L

更新日期：2004-08-01 00:00:00

abstract：:Octacalcium phosphate (OCP) {Ca8H2(PO4)6×5H2O] has attracted increasing attention over the last decade as a transient intermediate to the biogenic apatite for bone engineering and in studies involving the processes of pathological calcification. In this work, OCP powders obtained by hydrolysis of dicalcium phosphate d...

journal_title：Radiation research

authors： Shurtakova DV,Yavkin BV,Mamin GV,Orlinskii SB,Sirotinkin VP,Fedotov AY,Shinkarev A,Antuzevics A,Smirnov IV,Tovtin VI,Starostin EE,Gafurov MR,Komlev VS

更新日期：2020-12-10 00:00:00

abstract：:Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative to normal cells, cancer cells are believed to exist under a condition of chronic mitochondrial oxidative stress that is compensated for by increases in gluc...

journal_title：Radiation research

authors： Zahra A,Fath MA,Opat E,Mapuskar KA,Bhatia SK,Ma DC,Rodman SN III,Snyders TP,Chenard CA,Eichenberger-Gilmore JM,Bodeker KL,Ahmann L,Smith BJ,Vollstedt SA,Brown HA,Hejleh TA,Clamon GH,Berg DJ,Szweda LI,Spitz DR,Buat

更新日期：2017-06-01 00:00:00

abstract：:Identification of medical countermeasures (MCM) to mitigate radiation damage and/or protect first responders is a compelling unmet medical need. The prostaglandin E2 (PGE2) analog, 16,16 dimethyl-PGE2 (dmPGE2), has shown efficacy as a radioprotectant and radiomitigator that can enhance hematopoiesis and ameliorate int...

journal_title：Radiation research

authors： Patterson AM,Wu T,Chua HL,Sampson CH,Fisher A,Singh P,Guise TA,Feng H,Muldoon J,Wright L,Plett PA,Pelus LM,Orschell CM

更新日期：2020-12-10 00:00:00