Interim report of results from an international collaborative study of the Proposed International Reference Preparation of porcine pancreatic kininogenase.

Abstract:

:A collaborative study of the ampouled preparation of porcine pancreatic kininogenase, the Proposed International Reference Preparation (PIRP), was carried out, on behalf of the World Health Organization, by 19 laboratories in seven countries. The PIRP was studied using in vivo bioassays, immunoassays and in vitro enzyme assays involving natural protein substrate and small molecular ester and peptide substrates. An analysis of results obtained from a majority of the participating laboratories is presented. Comparison of the PIRP with the widely used Bayer house standard of porcine pancreatic kininogenase showed general agreement for estimates of relative activity, although differences were detected in some assay systems. The PIRP was shown to be stable and appears to be suitable to serve as an international reference preparation. Comparison of the PIRP with a preparation of highly purified human urinary kininogenase showed a wide diversity of estimates so that no general comparison of activities for these preparations is possible.

journal_name

Adv Exp Med Biol

authors

Das RE,Hartley RE,Bangham DR

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

253-62

eissn

0065-2598

issn

2214-8019

journal_volume

156

pub_type

杂志文章
  • Subglottic and tracheal stenosis due to Wegener's granulomatosis.

    abstract::Wegener's granulomatosis (WG) is characterized histologically by necrotizing granulomatous angitis that most commonly involves the upper, lower respiratory tract and kidneys, but may affect any organ system. Otolaryngological manifestations are frequent and diverse but subglottic stenosis and tracheal stenosis are les...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-94-007-4546-9_28

    authors: Zycinska K,Wardyn K,Zielonka TM,Nitsch-Osuch A,Zarzycki S,Demkow U,Lukas W,Pirogowicz I

    更新日期:2013-01-01 00:00:00

  • Effects of insect body size on tracheal structure and function.

    abstract::Fossilized insect specimens from the late Paleozoic Era (approximately 250 million years ago) were significantly larger than related extant species. Geologic estimates suggest that atmospheric oxygen in the late Paleozoic Era was 35%. These findings have led to a prominent hypothesis that insect body size may be limit...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-0-387-75434-5_17

    authors: Kirkton SD

    更新日期:2007-01-01 00:00:00

  • Air Pollution and Mortality in China.

    abstract::Ambient air pollution has been an important environmental issue in most areas of China. This chapter summarized the mortality effects of short-term and long-term exposures to various air pollutants among Chinese population. The literature review identified sufficient information to support significant short-term morta...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-10-5657-4_5

    authors: Lin H,Wang X,Liu T,Li X,Xiao J,Zeng W,Ma W

    更新日期:2017-01-01 00:00:00

  • Progenitors in the Ependyma of the Spinal Cord: A Potential Resource for Self-Repair After Injury.

    abstract::Traumatic injury of the spinal cord leads to devastating conditions that affect ~2.5 million people worldwide. This is because the mammalian spinal cord reacts to injury with only limited endogenous repair. Functional restoration requires the replacement of lost cells, the growth and navigation of regenerating axons o...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-62817-2_13

    authors: Marichal N,Reali C,Rehermann MI,Trujillo-Cenóz O,Russo RE

    更新日期:2017-01-01 00:00:00

  • Inhibitors of Angiogenesis.

    abstract::Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes. Here, we focus on anti-angiogenic therapies, which r...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-32805-8_12

    authors: Büning H,Hacker UT

    更新日期:2016-01-01 00:00:00

  • Early Neurodevelopmental Exposure to Low Lead Levels Induces Fronto-executive Dysfunctions That Are Recovered by Taurine Co-treatment in the Rat Attention Set-Shift Test: Implications for Taurine as a Psychopharmacotherapy Against Neurotoxicants.

    abstract::Lead (Pb2+) is a developmental neurotoxicant that causes lifelong cognitive dysfunctions. In particular, Pb2+-induced frontoexecutive dysfunctions emerge later in life when the cortex is fully myelinated, thereby permitting the ability to assess the extent to which Pb2+ has developmentally impacted higher order cognit...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-13-8023-5_70

    authors: Neuwirth LS,Kim Y,Barrerra ED,Jo C,Chrisphonte JM,Hameed N,Rubi S,Dacius TF Jr,Skeen JC,Bonitto JR,Khairi E,Iqbal A,Ahmed I,Masood S,Tranquilee B,Thiruverkadu V

    更新日期:2019-01-01 00:00:00

  • Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling.

    abstract::We investigated, with use of a technique of feedback analysis, the dynamic changes in and around the renin-angiotensin system in vivo induced by ACE inhibition. Prolonged studies were performed over a half year on rabbits, which were treated by daily injections of saline or one of the inhibitors as follows: captopril,...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-9543-4_27

    authors: Wada T,Aoyagi T

    更新日期:1989-01-01 00:00:00

  • Graphene-Based Nanocomposites as Promising Options for Hard Tissue Regeneration.

    abstract::Tissues are often damaged by physical trauma, infection or tumors. A slight injury heals naturally through the normal healing process, while severe injury causes serious health implications. Therefore, many efforts have been devoted to treat and repair various tissue defects. Recently, tissue engineering approaches ha...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-0950-2_6

    authors: Shin YC,Song SJ,Jeong SJ,Kim B,Kwon IK,Hong SW,Oh JW,Han DW

    更新日期:2018-01-01 00:00:00

  • Lumbar and thoracic spinal cord oxygen tension during aortic cross-clamping.

    abstract::In order to investigate the changes in tissue oxygen and the efficiency of the collateral circulation in the different regions of the spinal cord (SC) during aortic occlusion, surface PO2 (sPO2) was measured on the exposed SC in the pig in the lumbar (L3-5) as well as in the thoracic (Th6-8) parts before, during and a...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-3291-6_17

    authors: Wadouh F,Hartmann M,Arndt CF,Metzger H,Borst HG

    更新日期:1985-01-01 00:00:00

  • Computational Inferring of Risk Subpathways Mediated by Dysfunctional Non-coding RNAs.

    abstract::Non-coding RNAs mediated core elements of pathways contributes to the disorder of biological function in diseases. Identification of non-coding RNAs mediated subpathways not only can help for deciphering the pathogenic mechanism of complex diseases, but also can gain insight into the functional roles of non-coding RNA...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-0719-5_9

    authors: Xu Y,Zhang Y,Li X

    更新日期:2018-01-01 00:00:00

  • A quantitative study of oxygen as a metabolic regulator.

    abstract::An acute reduction in oxygen delivery to a tissue is associated with metabolic changes aimed at maintaining ATP homeostasis. However, given the complexity of the human bioenergetic system, it is difficult to determine quantitatively how cellular metabolic processes interact to maintain ATP homeostasis during stress (e...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-0075-9_52

    authors: Radhakrishnan K,LaManna JC,Cabrera ME

    更新日期:2003-01-01 00:00:00

  • Fructose Consumption and Lipid Metabolism in Obese Children and Adolescents.

    abstract::Inappropriate dietary habits influence the development of excessive body weight. The role of added sugars, including fructose, notably is significant in this process. It is estimated that fructose intake has increased many times over the past two centuries. The aim of the study was to define the effect of fructose con...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2018_330

    authors: Czerwonogrodzka-Senczyna A,Rumińska M,Majcher A,Credo D,Jeznach-Steinhagen A,Pyrżak B

    更新日期:2019-01-01 00:00:00

  • High resolution computed tomography in 2-year follow-up of Stage I sarcoidosis.

    abstract::There are as yet no markers known to predict the course of sarcoidosis. High resolution computed tomography (HRCT) is a tool that enables to visualize subtle parenchymal opacities in the lungs. Therefore, the aim of this study was to assess the prognostic role of HRCT at Stage I sarcoidosis. Fifty one patients (28 mal...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-94-007-6627-3_50

    authors: Ziora D,Kornelia K,Jastrzebski D,Labus L,Zieleznik K,Kozielski J

    更新日期:2013-01-01 00:00:00

  • Localization of the normal cellular src protein to the growth cone of differentiating neurons in brain and retina.

    abstract::The protooncogene c-src is implicated in the development of the vertebrate nervous system. Its product pp60c-src is a tyrosine-specific protein kinase that is expressed in two phases of neural development. An activated form of the pp60c-src is highly enriched in the membrane of nerve growth cones and in the proximal n...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4757-5876-4_10

    authors: Maness PF,Shores CG,Ignelzi M

    更新日期:1990-01-01 00:00:00

  • Model systems for studying kisspeptin signalling: mice and cells.

    abstract::Kisspeptins are a family of overlapping neuropeptides, encoded by the Kiss1 gene, that are required for activation and maintenance of the mammalian reproductive axis. Kisspeptins act within the hypothalamus to stimulate release of gonadotrophic releasing hormone and activation of the pituitary-gonadal axis. Robust mod...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-6199-9_22

    authors: Colledge WH,Doran J,Mei H

    更新日期:2013-01-01 00:00:00

  • Bioadhesive drug carriers for postoperative chemotherapy in bladder cancer.

    abstract::Transurethral resection (TUR) is the primary mode of therapy for both diagnosis and treatment of bladder cancer. Due to the recurrency of tumoral tissues after TUR further treatment is necessary which is usually in the form of intravesical chemotherapy or immunotherapy. But these therapies have some disadvantages such...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:

    authors: Oztürk E,Eroğlu M,Ozdemir N,Denkbaş EB

    更新日期:2004-01-01 00:00:00

  • Headspace volatile aldehydes as indicators of lipid oxidation in foods.

    abstract::Aldehydes are secondary breakdown products of unsaturated lipids. In particular, polyunsaturated lipid fatty acids of the omega-6 and omega-3 families are highly susceptible to oxidation. Using static headspace analysis, the specific aldehyde markers were studied. While linoleic, gamma-linolenic and arachidonic acids ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-1247-9_9

    authors: Shahidi F

    更新日期:2001-01-01 00:00:00

  • The antiinflammatory effects of methotrexate are mediated by adenosine.

    abstract::In summary, intermittent, low dose methotrexate treatment is: 1.) antiinflammatory in the murine air pouch model of inflammation; 2.) selectively increases intracellular AICAR concentration; 3.) increases adenosine concentration in an inflammatory exudate; and, 4.) inhibits leukocyte accumulation at an inflamed site b...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-2584-4_89

    authors: Cronstein BN,Naime D,Ostad E

    更新日期:1994-01-01 00:00:00

  • Impact of dietary fatty acid balance on membrane structure and function of neuronal tissues.

    abstract::Neural tissue has generally been viewed as resistant to structural changes induced by exogenous factors. Research has shown that the brain responds to changes in diet by altering neurotransmitter synthesis, and by shifting neuroendocrine controls over a variety of physiological events. Animal model research also indic...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-3426-6_17

    authors: Clandinin MT,Suh M,Hargreaves K

    更新日期:1992-01-01 00:00:00

  • The cerebral microcirculation in ischemia and hypoxemia. The Arisztid G. B. Kovách Memorial Lecture.

    abstract::The cerebral capillary circulation exhibits heterogenous perfusion and undergoes characteristic changes in the distribution of RBC flow in response to systemic physiological stimuli. Hypoxemia, hypercapnia and hypotension increase the homogeneity of capillary perfusion, which is thought to preserve or enhance transcap...

    journal_title:Advances in experimental medicine and biology

    pub_type:

    doi:10.1007/978-1-4615-0075-9_32

    authors: Hudetz AG

    更新日期:2003-01-01 00:00:00

  • The relationship between the vitamin D system and cancer.

    abstract::The classic function of 1,25-dihydroxyvitamin D3, the hormonally active form of vitamin D, is the maintenance of normal levels of calcium and phosphorus in the blood. 1,25-Dihydroxyvitamin D3 binds to a specific receptor protein and exerts its biologic action by a mechanism analogous to that proposed for other steroid...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4613-1835-4_30

    authors: DeLuca HF,Ostrem V

    更新日期:1986-01-01 00:00:00

  • Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-Derived Models for Drug Testing.

    abstract::Metastasis is the major cause of breast cancer death worldwide. In metastatic breast cancer, circulating tumor cells (CTCs) can be captured from patient blood samples sequentially over time and thereby serve as surrogates to assess the biology of surviving cancer cells that may still persist in solitary or multiple me...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-35805-1_5

    authors: Kujur PK,Flores BCT,Ramalingam N,Chinen LTD,Jeffrey SS

    更新日期:2020-01-01 00:00:00

  • Mitochondria-Targeted Antioxidants for the Treatment of Cardiovascular Disorders.

    abstract::The heart continuously supplies blood to the entire body throughout the lifetime, requiring a huge amount of the bioenergy molecule adenosine triphosphate (ATP). As the major subcellular organs that produce ATP through oxidative phosphorylation and the citrate-synthesis cycle, mitochondria inevitably produce chemicall...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-55330-6_32

    authors: Kim HK,Han J

    更新日期:2017-01-01 00:00:00

  • Sex-Specific Physiology and Cardiovascular Disease.

    abstract::Sex differences in cardiovascular diseases can be classified as those which are specific to one sex and those that differ in incidence, prevalence, etiology, symptomatology, response to treatment, morbidity, and mortality in one sex compared to the other. All sex differences in cardiovascular conditions have their bas...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-77932-4_27

    authors: Shufelt CL,Pacheco C,Tweet MS,Miller VM

    更新日期:2018-01-01 00:00:00

  • A systems approach to discovering signaling and regulatory pathways--or, how to digest large interaction networks into relevant pieces.

    abstract::In the post-genomic era, the first step in any study of protein function is a homology search against the complete genome sequence of the organism of interest. By analogy, if we also wish to elucidate the cadre of signaling and regulatory pathways in the cell, an extremely powerful first step is to construct a complet...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-8861-4_3

    authors: Ideker T

    更新日期:2004-01-01 00:00:00

  • Approaches on Generating Optimized Sequences of Items Used in Assessment.

    abstract::Assessment is a key element in education. Given its multiple methods, assessment contains the aspect of correctness and honesty from both the assessor and the assessed. These methods can be classified and their types are numerous, starting from single questions to tests and practical work. Concerning tests, their vast...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-56246-9_6

    authors: Popescu DA,Nijloveanu D,Bold N

    更新日期:2017-01-01 00:00:00

  • Lipofuscin as an indicator of oxidative stress and aging.

    abstract::There is a considerable body of evidence indicating that oxidative stress is a causal factor both in lipofuscinogenesis as well as in aging. Studies on the effects of pro-oxidants and antioxidants on lipofuscin accumulation in cultured rat cardiac myocytes and human glial cells indicated that pro-oxidants accelerate w...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4899-5339-1_2

    authors: Sohal RS,Brunk UT

    更新日期:1989-01-01 00:00:00

  • Cytokine blockade in rheumatoid arthritis.

    abstract::As we enter the 2000's it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFalpha therapy, the current status of therapy and focus on the regulation of TNFalpha production in rheumatoid synovium. New approaches ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-1243-1_13

    authors: Feldmann M,Maini RN,Bondeson J,Taylor P,Foxwell BM,Brennan FM

    更新日期:2001-01-01 00:00:00

  • Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs.

    abstract::The unsatisfactory results of current anti-cancer therapies require the active search for new drugs, new treatment strategies and a deeper understanding of the host-tumour relationship. From this point of view, the drugs with a capacity to substitute the functions of altered tumour suppressor genes are of prominent in...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:

    authors: Hajdúch M,Havlíèek L,Veselý J,Novotný R,Mihál V,Strnad M

    更新日期:1999-01-01 00:00:00

  • Roles of Mitochondrial DNA in Energy Metabolism.

    abstract::Mitochondria are independent double-membrane organelles responsible for energy production, specifically by completing oxidative phosphorylation. Mitochondria are essential to regulate energy metabolism, signaling pathways, and cell death. Mitochondrial DNA (mtDNA) can be altered by metabolic disorders, oxidative stres...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-10-6674-0_6

    authors: Lv J,Bhatia M,Wang X

    更新日期:2017-01-01 00:00:00