Extracorporeal membrane oxygenation for severe acute respiratory failure.


:Extracorporeal membrane oxygenation (ECMO) is a technique for providing life support, in case the natural lungs are failing and are not able to maintain a sufficient oxygenation of the body's organ systems. ECMO technique was an adaptation of conventional cardiopulmonary bypass techniques and introduced into treatment of severe acute respiratory distress syndrome (ARDS) in the 1970s. The initial reports of the use of ECMO in ARDS patients were quite enthusiastic, however, in the following years it became clear that ECMO was only of benefit in newborns with acute respiratory failure. In neonates treated with ECMO, survival rates of 80% could be achieved. In adult patients with ARDS, two large randomized controlled trials (RCTs) published in 1979 and 1994 failed to show an advantage of ECMO over conventional treatment; survival rates were only 10% and 33%, respectively, in the ECMO groups. Since then, ECMO technology as well as conventional treatment of adult ARDS have undergone further improvements. In conventional treatment lung-protective ventilation strategies were introduced and ECMO was made safer by applying heparin-coated equipment, membranes and tubings. Many ECMO centres now use these advanced ECMO technology and report survival rates in excess of 50% in uncontrolled data collections. The question, however, of whether the improved ECMO can really challenge the advanced conventional treatment of adult ARDS is unanswered and will need evaluation by a future RCT.


Crit Care


Lewandowski K





Has Abstract


2000-01-01 00:00:00












  • The World Trade Center attack. Lessons for all aspects of health care.

    abstract::The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness has now been replaced by anger, fear, and the determination to be better prepared next time. This determination not onl...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Tamber PS,Vincent JL

    更新日期:2001-12-01 00:00:00

  • Bench-to-bedside review: Beta-adrenergic modulation in sepsis.

    abstract::Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: de Montmollin E,Aboab J,Mansart A,Annane D

    更新日期:2009-01-01 00:00:00

  • Stenting versus aggressive medical therapy for intracranial arterial stenosis: more harm than good.

    abstract:BACKGROUND:Atherosclerotic intracranial arterial stenosis is an important cause of stroke that is increasingly being treated with percutaneous transluminal angioplasty and stenting (PTAS) to prevent recurrent stroke. However, PTAS has not been compared with medical management in a randomized trial. METHODS:Objective: ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Al Hasan M,Murugan R

    更新日期:2012-05-09 00:00:00

  • Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study.

    abstract:INTRODUCTION:Resuscitation with saline is a standard initial response to hypotension or shock of almost any cause. Saline resuscitation is thought to generate an increase in cardiac output through a preload-dependent (increased end-diastolic volume) augmentation of stroke volume. We sought to confirm this to be the mec...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Kumar A,Anel R,Bunnell E,Zanotti S,Habet K,Haery C,Marshall S,Cheang M,Neumann A,Ali A,Kavinsky C,Parrillo JE

    更新日期:2004-06-01 00:00:00

  • Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock.

    abstract:INTRODUCTION:This prospective, randomized, controlled, experimental animal study looks at the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and microcirculation in ovine acute lung injury (ALI) and septic shock, resulting from smoke inhalation injury. METHODS:Twenty-one sheep (37 ± 2 ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Maybauer MO,Maybauer DM,Fraser JF,Szabo C,Westphal M,Kiss L,Horvath EM,Nakano Y,Herndon DN,Traber LD,Traber DL

    更新日期:2010-01-01 00:00:00

  • How the relationships between general practitioners and intensivists can be improved: the general practitioners' point of view.

    abstract:INTRODUCTION:The present study assessed the opinion of general practitioners (GPs) concerning their relationships with intensivists. METHODS:An anonymous questionnaire was mailed to 7,239 GPs. GPs were asked about their professional activities, postgraduate intensive care unit (ICU) training, the rate of patient admit...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Etesse B,Jaber S,Mura T,Leone M,Constantin JM,Michelet P,Zoric L,Capdevila X,Malavielle F,Allaouchiche B,Orban JC,Fabbro-Peray P,Lefrant JY,AzuRéa Group.

    更新日期:2010-01-01 00:00:00

  • N-terminal pro-brain natriuretic peptide as an early prognostic factor in cancer patients developing septic shock.

    abstract:INTRODUCTION:The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS:We designed a prospective, consecutive, observational study over a one-ye...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Mokart D,Sannini A,Brun JP,Faucher M,Blaise D,Blache JL,Faucher C

    更新日期:2007-01-01 00:00:00

  • A 10-second fluid challenge guided by transthoracic echocardiography can predict fluid responsiveness.

    abstract:INTRODUCTION:The accurate assessment of intravascular volume status for the therapy of severe hypovolemia and shock is difficult and critical to critically ill patients. Non-invasive evaluation of fluid responsiveness by the rapid infusion of a very limited amount of volume is an important clinical goal. This study aim...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Wu Y,Zhou S,Zhou Z,Liu B

    更新日期:2014-05-27 00:00:00

  • Partial pressure of end-tidal carbon dioxide successful predicts cardiopulmonary resuscitation in the field: a prospective observational study.

    abstract:INTRODUCTION:Prognosis in patients suffering out-of-hospital cardiac arrest is poor. Higher survival rates have been observed only in patients with ventricular fibrillation who were fortunate enough to have basic and advanced life support initiated soon after cardiac arrest. An ability to predict cardiac arrest outcome...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Kolar M,Krizmaric M,Klemen P,Grmec S

    更新日期:2008-01-01 00:00:00

  • Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study.

    abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival probability among adult hospitalized patients with COVID-19. METHODS:In this multicent...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Zhang S,Guo M,Duan L,Wu F,Hu G,Wang Z,Huang Q,Liao T,Xu J,Ma Y,Lv Z,Xiao W,Zhao Z,Tan X,Meng D,Zhang S,Zhou E,Yin Z,Geng W,Wang X,Zhang J,Chen J,Zhang Y,Jin Y

    更新日期:2020-07-16 00:00:00

  • Early goal-directed resuscitation of patients with septic shock: current evidence and future directions.

    abstract::Severe sepsis and septic shock are among the leading causes of mortality in the intensive care unit. Over a decade ago, early goal-directed therapy (EGDT) emerged as a novel approach for reducing sepsis mortality and was incorporated into guidelines published by the international Surviving Sepsis Campaign. In addition...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Gupta RG,Hartigan SM,Kashiouris MG,Sessler CN,Bearman GM

    更新日期:2015-08-28 00:00:00

  • Central venous pressure measurement is associated with improved outcomes in septic patients: an analysis of the MIMIC-III database.

    abstract:PURPOSE:Measurement of central venous pressure (CVP) can be a useful clinical tool. However, the formal utility of CVP measurement in preventing mortality in septic patients has never been proven. METHODS:The Medical Information Mart for Intensive Care III (MIMIC-III) database was searched to identify septic patients ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chen H,Zhu Z,Zhao C,Guo Y,Chen D,Wei Y,Jin J

    更新日期:2020-07-14 00:00:00

  • Psychological intervention to prevent ICU-related PTSD: who, when and for how long?

    abstract::Experiencing treatment on a modern intensive care unit (ICU) is a potentially traumatic event. People who experience traumatic events have an increased risk of depression, anxiety disorders and post-traumatic stress disorder (PTSD). Extended follow-up has confirmed that many patients suffer physical and psychological ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Hatch R,McKechnie S,Griffiths J

    更新日期:2011-01-01 00:00:00

  • Critically ill patients with Middle East respiratory syndrome coronavirus infection.

    abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available f...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Al-Dorzi HM,Alsolamy S,Arabi YM

    更新日期:2016-03-16 00:00:00

  • The incretin effect in critically ill patients: a case-control study.

    abstract:INTRODUCTION:Patients admitted to the intensive care unit often develop hyperglycaemia, but the underlying mechanisms have not been fully described. The incretin effect is reduced in patients with type 2 diabetes. Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resis...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Nielsen ST,Janum S,Krogh-Madsen R,Solomon TP,Møller K

    更新日期:2015-11-16 00:00:00

  • Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance.

    abstract::Five to 10% of the coronavirus SARS-CoV-2-infected patients, i.e., with new coronavirus disease 2019 (COVID-19), are presenting with an acute respiratory distress syndrome (ARDS) requiring urgent respiratory and hemodynamic support in the intensive care unit (ICU). However, nutrition is an important element of care. T...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Thibault R,Seguin P,Tamion F,Pichard C,Singer P

    更新日期:2020-07-19 00:00:00

  • Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study.

    abstract:INTRODUCTION:Manifestations of sepsis are sensitive but are poorly specific of infection. Our aim was to assess the value of daily measurements of C-reactive protein (CRP), temperature and white cell count (WCC) in the early identification of intensive care unit (ICU)-acquired infections. METHODS:We undertook a prospe...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Póvoa P,Coelho L,Almeida E,Fernandes A,Mealha R,Moreira P,Sabino H

    更新日期:2006-01-01 00:00:00

  • Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review.

    abstract:INTRODUCTION:Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several limitations. A surge of interest exists in the use of point-of-care tests to diagnose hypo- and hypercoagulability in sepsis. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched from 1 Janu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Müller MC,Meijers JC,Vroom MB,Juffermans NP

    更新日期:2014-02-10 00:00:00

  • Presence of Candida cell wall derived polysaccharides in the sera of intensive care unit patients: relation with candidaemia and Candida colonisation.

    abstract:INTRODUCTION:Prompt diagnosis of candidaemia and invasive candidosis is crucial to the early initiation of antifungal therapy. The poor sensitivity of blood cultures (BCs) has led to the development of fungal glycan tests as a diagnostic adjunct. We analysed the performance of tests for the detection of circulating β-D...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Poissy J,Sendid B,Damiens S,Ichi Ishibashi K,François N,Kauv M,Favory R,Mathieu D,Poulain D

    更新日期:2014-06-29 00:00:00

  • Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock.

    abstract:INTRODUCTION:Stimulation of beta2-adrenergic receptors (beta2-ARs) inhibits tumor necrosis factor-alpha (TNF-alpha) release in monocytes. In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. The aims of this study were to analyze the molecular mechanisms ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Link A,Selejan S,Maack C,Lenz M,Böhm M

    更新日期:2008-01-01 00:00:00

  • The influence of body composition on therapeutic hypothermia: a prospective observational study of patients after cardiac arrest.

    abstract:INTRODUCTION:Patients after out-of-hospital cardiac arrest (OHCA) benefit from therapeutic hypothermia for 24 hours. The time needed to reach hypothermia (target temperature of 32 degrees C to 34 degrees C) varies widely. In this study, we explore the relation between measures of body composition and the time needed to...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Jimmink JJ,Binnekade JM,Paulus F,Mathus-Vliegen EM,Schultz MJ,Vroom MB

    更新日期:2008-01-01 00:00:00

  • Automatic detection of ventilatory modes during invasive mechanical ventilation.

    abstract:BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Murias G,Montanyà J,Chacón E,Estruga A,Subirà C,Fernández R,Sales B,de Haro C,López-Aguilar J,Lucangelo U,Villar J,Kacmarek RM,Blanch L

    更新日期:2016-08-14 00:00:00

  • Hyperoncotic colloids and acute kidney injury: a meta-analysis of randomized trials.

    abstract:INTRODUCTION:It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear. METHODS:A meta-analysis was conducted of randomized controlled trials evaluating AKI after infusion of hyperoncotic albumin and hydroxyethyl starch (...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析


    authors: Wiedermann CJ,Dunzendorfer S,Gaioni LU,Zaraca F,Joannidis M

    更新日期:2010-01-01 00:00:00

  • Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis.

    abstract:OBJECTIVE:In septic patients, multiple retrospective studies show an association between large volumes of fluids administered in the first 24 h and mortality, suggesting a benefit to fluid restrictive strategies. However, these studies do not directly estimate the causal effects of fluid-restrictive strategies, nor do ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Shahn Z,Shapiro NI,Tyler PD,Talmor D,Lehman LH

    更新日期:2020-02-22 00:00:00

  • Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.

    abstract::Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a systems-based approach, similar to that in acute myocardial infarction, stroke and trauma, called ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Nguyen HB,Jaehne AK,Jayaprakash N,Semler MW,Hegab S,Yataco AC,Tatem G,Salem D,Moore S,Boka K,Gill JK,Gardner-Gray J,Pflaum J,Domecq JP,Hurst G,Belsky JB,Fowkes R,Elkin RB,Simpson SQ,Falk JL,Singer DJ,Rivers EP

    更新日期:2016-07-01 00:00:00

  • Long term effect of a medical emergency team on cardiac arrests in a teaching hospital.

    abstract:INTRODUCTION:It is unknown whether the reported short-term reduction in cardiac arrests associated with the introduction of the medical emergency team (MET) system can be sustained. METHOD:We conducted a prospective, controlled before-and-after examination of the effect of a MET system on the long-term incidence of ca...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Jones D,Bellomo R,Bates S,Warrillow S,Goldsmith D,Hart G,Opdam H,Gutteridge G

    更新日期:2005-01-01 00:00:00

  • Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients.

    abstract:INTRODUCTION:Tight glucose control therapy (TGC) has been implemented to control hyperglycemia in ICU patients. TGC may also influence serum potassium concentrations. We therefore investigated the influence of TGC on both serum glucose and serum potassium concentrations and associated mortality. METHOD:We performed a ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Uijtendaal EV,Zwart-van Rijkom JE,de Lange DW,Lalmohamed A,van Solinge WW,Egberts TC

    更新日期:2015-06-22 00:00:00

  • The benefit of specialized team approaches in patients with acute kidney injury undergoing continuous renal replacement therapy: propensity score matched analysis.

    abstract:INTRODUCTION:Continuous renal replacement therapy (CRRT) has been widely used in critically ill acute kidney injury (AKI) patients. Moreover, some centers operate a specialized CRRT team (SCT) composed of physicians and nurses, but few studies have yet determined the superiority of SCT control. METHODS:A total of 334 ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Oh HJ,Lee MJ,Kim CH,Kim DY,Lee HS,Park JT,Na S,Han SH,Kang SW,Koh SO,Yoo TH

    更新日期:2014-08-13 00:00:00

  • Glucose absorption and gastric emptying in critical illness.

    abstract:INTRODUCTION:Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and ab...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chapman MJ,Fraser RJ,Matthews G,Russo A,Bellon M,Besanko LK,Jones KL,Butler R,Chatterton B,Horowitz M

    更新日期:2009-01-01 00:00:00

  • Estimation of the diameter and cross-sectional area of the internal jugular veins in adult patients.

    abstract:INTRODUCTION:Unawareness of an asymmetry between the right and left internal jugular vein (IJV) and methodological pitfalls in previous studies raise concerns about such asymmetry. Hence the aim of this prospective non-interventional study was to validate the hypothesis that right IJV diameter is greater than those of ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Tartière D,Seguin P,Juhel C,Laviolle B,Mallédant Y

    更新日期:2009-01-01 00:00:00