Abstract：
:Since there appears to be an association between depressed lymphocyte function and liver disease, the effect of bile salts on lymphocyte function was determined in vitro. Peripheral lymphocytes from normal volunteers were incubated with varying concentrations of three bile salts (chenodeoxycholate, deoxycholate, or ursodeoxycholate) and stimulated by the mitogens phytohemagglutinin or concanavalin. The three bile salt concentrations used in these experiments were 75, 100, and 250, mumol/L, which are similar to serum levels found in various types of liver disease. Blast transformation, as measured by tritiated thymidine incorporation, was significantly depressed by all three bile salts at all concentrations and with both mitogens. Suppression increased with the higher bile salt concentrations. However, ursodeoxycholate suppressed lymphocyte function significantly less than did either chenodeoxycholate or deoxycholate. These data suggest that elevated serum bile levels associated with liver disease may contribute to immunosuppression and that ursodeoxycholate, an epimer of chenodeoxycholate that is used for gallstone dissolution, depresses lymphocyte function significantly less than does chenodeoxycholate.
journal_name
Surgeryjournal_title
Surgeryauthors
Keane RM,Gadacz TR,Munster AM,Birmingham W,Winchurch RAsubject
Has Abstractpub_date
1984-04-01 00:00:00pages
439-43issue
4eissn
0039-6060issn
1532-7361journal_volume
95pub_type
杂志文章相关文献
SURGERY文献大全abstract：:A patient who underwent jejunoileal bypass for morbid obesity developed servere renal failure associated with hyperoxaluria and renal oxalosis. Renal function improved and oxalate excretion decreased following hemodialysis and restoration of gastrointestinal continuity. ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：BACKGROUND:Although intracellular protease activation is thought to be an early event in acute pancreatitis, factors determining progression from edematous to necrotizing pancreatitis are largely unknown. With enterokinase as a probe and an immunoassay quantifying free trypsinogen activation peptides (TAP), we sought e...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:Mortality after acute respiratory distress syndrome is higher in males than in females. Gender differences in pulmonary vascular reactivity and local inflammatory response may explain this disparity. We hypothesized that endothelium-dependent pulmonary vasorelaxation is impaired in males and that this effect...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.03.002
更新日期：2005-07-01 00:00:00
abstract：:To further define the clinicopathologic features and determinants of survival, we reviewed the cases of 110 patients with primary hepatic malignancy managed surgically between 1975 and 1986. Presenting signs of symptoms were pain (57%), fatigue (48%), abdominal mass (40%), and weight loss (33%). Twenty-six percent of ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：BACKGROUND:Primary hyperparathyroidism is associated with an increased cardiovascular morbidity and mortality. However, mechanisms underlying this association are currently unclear. As there is clear evidence of the independent role of aldosterone on the cardiovascular system, the aim of this study was to evaluate aldo...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.09.041
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Interferon regulatory factor-1 (IRF-1) is a transcriptional factor originally cloned from fibroblasts that activates interferons and certain interferon-responsive genes. Because IRF-1 is an "early-immediate" nuclear protein, it can function acutely after trauma or septic stimuli. We have identified IRF-1 exp...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:The correct timing of surgery in cases of gallstone pancreatitis is debatable. To delineate more clearly the influence of the timing of surgery in the treatment of the disease, a prospective randomized clinical study of early surgery (less than 48 hours after admission) and delayed surgery (more than 48 hours after ad...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1988-10-01 00:00:00
abstract：BACKGROUND:Discrimination of malignant proximal bile duct (PBD) stricture from a benign lesion is difficult with nonsurgical methods; indeed, 8% to 13% of PBD strictures prove to be benign after histologic examination of the surgically resected specimen. METHODS:In a 7-year period 178 patients with PBD stricture were ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Patients undergoing ventral hernia repair (VHR) are at risk of an inadvertent enterotomy during surgery. Inadvertent enterotomies potentially contaminate the surgical field presenting a management dilemma for the surgeon. The aim of our study was to define the incidence and risk factors for a recognized inad...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.04.003
更新日期：2018-08-01 00:00:00
abstract：:During the 23-year period from January 1959 to February 1982, 142 patients (78 men and 64 women) underwent arterial reconstructive operations for obstruction of the brachiocephalic arteries. A single vessel was involved in 75% and multiple vessels were involved in 25% of the cases. Distal involvement of internal carot...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND:Hypoparathyroidism is the most frequent permanent complication of thyroid surgery. Our hypothesis is that human precursor cells in culture can be differentiated into parathyroid cells and used to reconstitute function. Human embryonic stem cells (hESCs) are a stable model to study differentiation into parath...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.09.021
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Outcomes after operative management of benign hepatic lesions are ill-defined. We sought to define patient-reported quality of life (QOL) postoperatively for benign hepatic tumors. METHODS:Patients who underwent surgery for benign liver lesions (n = 255) were invited to complete a QOL survey designed using ...
journal_title：Surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.surg.2012.05.004
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Little is known about the value of sequential transcatheter arterial chemoembolization and portal vein embolization compared with portal vein embolization alone before major hepatectomy for large hepatocellular carcinoma. We aimed to compare early and long-term outcomes of these two strategies. METHODS:We i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.09.023
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Complex anal fistulas are unsuitable for fistulotomy because of the risk of fecal incontinence. The anal fistula plug (AFP) has demonstrated fistula healing without sphincter division. This study aims to evaluate the cost-effectiveness of the AFP compared to the endoanal advancement flap (EAAF) as an alterna...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.05.018
更新日期：2010-01-01 00:00:00
abstract：:To compare the effects on canine ciliary and bronchial mucosal function of varying periods of ventilation with dry vs. humidified gas mixtures, 29 anesthetized dogs underwent 2, 4, and 6 hours of ventilation through a Carlen's double-lumen tube. Six dogs were evaluated by clearance studies, nine by differential bronch...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：BACKGROUND:Venous thromboembolism, presenting as deep vein thrombosis or pulmonary embolism, can be associated with considerable morbidity after major abdominal and pelvic surgery. Perioperative thromboprophylaxis with low-molecular-weight heparin is well established, but the duration of treatment remains debated. We a...
journal_title：Surgery
pub_type： 杂志文章,meta分析
doi：10.1016/j.surg.2018.05.028
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:A pathologic complete response (pCR) can be observed in up to 25% of patients after preoperative chemoradiotherapy for rectal cancer and is associated with an improved long-term prognosis. However, few data are available regarding the effect of pCR on postoperative morbidity. This study aimed to assess the i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Postoperative pancreatic fistula represents the most important complication after distal pancreatectomy. The aim of this study was to evaluate the use of a preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula (German Clinical Trials Regis...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2016.09.005
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Permanent hypoparathyroidism is common after thyroidectomy. The present study evaluated the risk for morbidity in patients operated with total thyroidectomy with and without permanent hypoparathyroidism. METHODS:Data was retrieved from the Scandinavian Quality Register for Thyroid, Parathyroid, and Adrenal ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.06.056
更新日期：2020-01-01 00:00:00
abstract：:A case report of a patient with Marfan's syndrome who developed acute supravalvular aortic stenosis following aortic valve replacement and reconstruction of the ascending aorta is presented. Early recognition of this complication permitted reoperation and successful repair. One similar case has been reported previousl...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Management of critically ill patients is a challenge in low resource settings where there is a paucity of trained staff, infrastructure, resources, and drugs. We aimed to study the characteristics of surgical patients admitted in intensive care unit in a limited resource setting and determine factors associa...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.04.010
更新日期：2019-08-01 00:00:00
abstract：:This study examined whether treatment with the oxygen free radical scavengers, superoxide dismutase and catalase, could improve functional recovery in hearts subjected to regional ischemia and global cardioplegic arrest. Regional left ventricular (LV) function was assessed in open chest pigs with sonomicrometry and mi...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:Up to 70% of children with small bowel transplantation (SBTx) experience acute cellular rejection (ACR). Allospecific CD154+ T cells predict liver ACR in children in a novel, 16-hour mixed leukocyte response (MLR) assay, but remain untested in SBTx. METHODS:The expression of CD154 was measured in 4 subsets-...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.04.006
更新日期：2009-08-01 00:00:00
abstract：:We will describe the development of new resectional techniques with the use of the ultrasonic scalpel in 33 patients with liver disease. Our experience is presented in the performance of anatomic and nonanatomic liver resections by use of this device. Its saline-cooled tip vibrated at ultrasonic frequencies and select...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：BACKGROUND AND AIMS:The optimal protocol of the treatment for early gastric cancer has not been fully established. The current study was designed to elucidate the relationship between the depth of tumors with or without an ulcer and the presence of lymph node metastasis and to establish the optimal and practical therap...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.114217
更新日期：2001-06-01 00:00:00
abstract：:A modification of cholangiomanometry in which the papilla of Vater was stimulated by hydrochloric acid was devised as a means to evaluate the papillary function. Manometric tracings could be classified into four patterns according to the mode of response to hydrochloric acid of the papilla. Pattern I was the type in w...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Activated nuclear factor-kappaB (NF-kappaB) is associated reportedly with the pathogenesis of numerous malignancies. This study investigated whether a common insertion (ins)/deletion (del) polymorphism (-94 ins/del ATTG) in the NFKB1 promoter is associated with susceptibility to gastric cancer and its tumor ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.11.001
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:The goal of the current study is to characterize the presentation, therapy, and outcomes of acute limb ischemia (ALI) associated with type B aortic dissection (AoD). METHODS:The prospective/retrospective International Registry for Acute Aortic Dissection (IRAD) database and a single institutional database w...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.06.019
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:The process of extrinsic reinnervation after small bowel transplantation is poorly understood. METHODS:Jejunal and ileal specimens, obtained from the dogs that underwent intestinal autotransplantation by an end-to end (E-E) or end-to-side arterial reconstruction, were analyzed at 1 (n = 7), 3 (n = 6), 6 (n ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:The effect of the time interval between colorectal and liver resection for metastatic lesions on the patient's survival remains controversial. Pretreatment classification for predicting the prognosis of this disease has not yet been reported. METHODS:Nine clinical factors revealed by preoperative examinatio...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2001.112001
更新日期：2001-04-01 00:00:00
