CSF smooth-muscle constrictor activity associated with cerebral vasospasm and mortality in SAH patients.

Abstract:

:Cerebrospinal fluid (CSF) was collected preoperatively (by lumbar puncture) or perioperatively (by lumbar or ventricular drain) from 32 patients with subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms. Samples were also obtained from six control patients without evidence of subarachnoid blood. Smooth-muscle constrictor activity in the CSF was measured by bioassay using the isolated rat stomach fundus preparation. Concentrations of unidentified smooth-muscle constrictor substances were considerably greater in CSF from a group of seven patients with evidence of severe angiographic vasospasm and/or delayed ischemic deficits who died (73.8 +/- 39.7 nmol/liter prostaglandin E2 (PGE2) equivalents), as compared to 25 other SAH patients who survived (6.5 +/- 1.4 nmol/liter PGE2 equivalents), and six control patients (1.17 +/- 0.34 nmol/liter PGE2 equivalents). The data suggest that there is a relationship between smooth-muscle constrictor substances in the CSF after SAH and both the degree of angiographic vasospasm and the outcome. It is possible that this relationship might be exploited clinically.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Kaye AH,Tagari PC,Teddy PJ,Adams CB,Blaso WP,Boullin DJ

doi

10.3171/jns.1984.60.5.0927

subject

Has Abstract

pub_date

1984-05-01 00:00:00

pages

927-34

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

60

pub_type

杂志文章
  • Hemostasis activation in patients undergoing brain tumor surgery.

    abstract::Patients undergoing brain tumor surgery are at high risk for the occurrence of a thromboembolic event. To identify a laboratory marker suitable for risk estimation the authors studied the perioperative time pattern of routine coagulation parameters and the specific hemostasis activation marker D-dimer in 28 consecutiv...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.87.4.0508

    authors: Vukovich TC,Gabriel A,Schaeffer B,Veitl M,Matula C,Spiss CK

    更新日期:1997-10-01 00:00:00

  • Spinal cord injury without radiographic abnormality and Chiari malformation.

    abstract::Spinal cord injury without radiographic abnormality and asymptomatic Chiari I malformation have an unusual coincidence. A young boy who had recently fallen from his porch was transferred to the neurosurgery service with a high cervical central cord syndrome. Careful study demonstrated no radiographic abnormality and, ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1993.79.6.0833

    authors: Bondurant CP,Oró JJ

    更新日期:1993-12-01 00:00:00

  • Pressure-dependent effect of shock waves on rat brain: induction of neuronal apoptosis mediated by a caspase-dependent pathway.

    abstract:OBJECT:Shock waves have been experimentally applied to various neurosurgical treatments including fragmentation of cerebral emboli, perforation of cyst walls or tissue, and delivery of drugs into cells. Nevertheless, the application of shock waves to clinical neurosurgery remains challenging because the threshold for s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2007.106.4.667

    authors: Kato K,Fujimura M,Nakagawa A,Saito A,Ohki T,Takayama K,Tominaga T

    更新日期:2007-04-01 00:00:00

  • History of neurosurgery at University of Toronto: the St. Michael's story.

    abstract::In this paper, the authors describe the history of neurosurgery at St. Michael's Hospital, University of Toronto. St. Michael's has long been regarded as one of the top teaching and research hospitals in Canada. A detailed literature review of published and unpublished works was performed to formulate a succinct but i...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/2016.9.JNS161119

    authors: Alotaibi NM,Guha D,Ahuja CS,Spears J,Muller PJ,Tucker WS,Hudson AR,Macdonald RL

    更新日期:2017-12-01 00:00:00

  • Leptomeningeal cyst of the posterior fossa. Case report.

    abstract::A patient with a posttraumatic leptomeningeal cyst is described. The cyst simulated an occipital encephalocele and communicated with an epidural cerebrospinal fluid collection in the posterior fossa. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.5.0704

    authors: Nemoto S,Hoffman HJ

    更新日期:1986-11-01 00:00:00

  • Gamma knife surgery of superficially located meningioma.

    abstract:OBJECT:The authors analyzed tumor control rates and complications in patients with superficially located meningiomas after gamma knife surgery (GKS). METHODS:Between 1998 and 2003, GKS was performed in 23 patients with 26 lesions in whom follow-up imaging for 1 year or more was available. The male/female ratio was 1:2...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.s_supplement.0255

    authors: Kim DG,Kim ChH,Chung HT,Paek SH,Jeong SS,Han DH,Jung HW

    更新日期:2005-01-01 00:00:00

  • Clinical and electroneurographic evaluation of sensory/motor-differentiated nerve repair in the hand.

    abstract::In 17 patients acetylcholinesterase activity was used to differentiate between sensory and motor fascicles in median and ulnar nerve repair of the hand. Eleven patients received follow-up evaluation 1 to 11 years after surgery, and at that time clinical and electroneurographic examinations were performed to evaluate t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.78.5.0709

    authors: Deutinger M,Girsch W,Burggasser G,Windisch A,Mayr N,Freilinger G

    更新日期:1993-05-01 00:00:00

  • Value of gas myelography in early management of acute cervical spinal cord injuries.

    abstract::Gas myelography was carried out in 22 patients with acute cervical spinal cord injuries in whom oily contrast media seemed contraindicated. The authors believe this technique makes a valuable contribution to the basic decision regarding the surgical versus medical treatment of a specific patient with a cervical cord i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.42.3.0330

    authors: Rossier AB,Berney J,Rosenbaum AE,Hachen J

    更新日期:1975-03-01 00:00:00

  • Imaging of spontaneous intraventricular rupture of a septum pellucidum colloid cyst: case report.

    abstract::Intraventricular rupture of a colloid cyst is a rare phenomenon and has been proposed as a mechanism for sudden death in patients with colloid cysts. Imaging of a colloid cyst during rupture has been described in only one other instance. The authors report a highly unusual case of a 53-year-old man who presented with ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.5.JNS153015

    authors: Westwick HJ,Obaid S,Morin-Roy F,Champagne PO,Bouthillier A

    更新日期:2017-06-01 00:00:00

  • Racial phenotypes in moyamoya disease: a comparative analysis of clinical presentation and natural history in a single multiethnic cohort of 250 hemispheres.

    abstract:OBJECTIVE:The authors aimed to determine whether differences exist in presentation and natural history when comparing Asian patients with moyamoya disease (MMD) to those of other ethnicities in North America. METHODS:A database of 137 patients with MMD presenting to their institution between 1994 and 2015 was reviewed...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.7.JNS191507

    authors: Feghali J,Xu R,Yang W,Liew J,Tamargo RJ,Marsh EB,Huang J

    更新日期:2019-10-04 00:00:00

  • Endoscopic transorbital surgery for Meckel's cave and middle cranial fossa tumors: surgical technique and early results.

    abstract::OBJECTIVETumors involving Meckel's cave remain extremely challenging because of the surrounding complex neurovascular structures and deep-seated location. The authors investigated a new minimal-access technique using the endoscopic transorbital approach (eTOA) through the superior eyelid crease to Meckel's cave and mi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.6.JNS181099

    authors: Jeon C,Hong CK,Woo KI,Hong SD,Nam DH,Lee JI,Choi JW,Seol HJ,Kong DS

    更新日期:2018-11-01 00:00:00

  • Effect of regional spinal cord blood flow and central control in recovery from spinal cord injury.

    abstract::Forty-two cats were subjected to decerebration, thoracic and lumbar laminectomies, and isolation of the sciatic nerves. Spinal evoked potentials in response to bilateral sciatic nerve stimulation were recorded at L-3, and the spinal cord blood flow (SCBF) was measured by the hydrogen clearance technique. Thoracic cord...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.71.5.0747

    authors: Chehrazi BB,Scremin O,Decima EE

    更新日期:1989-11-01 00:00:00

  • Safe removal of retained ventricular catheters using intraluminal choroid plexus coagulation. Technical note.

    abstract::The authors describe a simple technique that reduces the incidence of retained ventricular catheters and minimizes the risk of life-threatening intraventricular hemorrhage during the removal of an obstructed, adherent ventricular catheter in patients with hydrocephalus. The technique requires no special equipment and ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.6.1101

    authors: Whitfield PC,Guazzo EP,Pickard JD

    更新日期:1995-12-01 00:00:00

  • New York City at the dawn of neurological surgery.

    abstract::Although there are many cities that can claim to have been the incubator of modern neurological surgery, the rise of this surgical subspecialty in New York City in the late 19th and early 20th century mirrors what was occurring around the world. The first confirmed brain tumor operation in the US was performed there i...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/2015.7.JNS15732

    authors: Solomon RA

    更新日期:2016-11-01 00:00:00

  • Molecular genetic investigation of the neurofibromatosis type 2 tumor suppressor gene in sporadic meningioma.

    abstract::The authors investigated the role of somatic mutations of the neurofibromatosis type 2 (NF2) gene in sporadic meningioma. Neurofibromatosis 2 is a dominantly inherited familial tumor syndrome predisposing affected patients to a variety of central nervous system tumors including vestibular schwannoma and meningioma. Ne...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.84.5.0847

    authors: Harada T,Irving RM,Xuereb JH,Barton DE,Hardy DG,Moffat DA,Maher ER

    更新日期:1996-05-01 00:00:00

  • Atretic cephalocele: the tip of the iceberg.

    abstract::Atretic cephalocele appears as an unimportant and benign lesion. This malformation consists of meningeal and vestigial tissues (arachnoid, glial, or central nervous system rests). The authors report the findings in 16 cases (seven parietal and nine occipital) of rudimentary cephaloceles. Twelve patients presented with...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.2.0230

    authors: Martinez-Lage JF,Sola J,Casas C,Poza M,Almagro MJ,Girona DG

    更新日期:1992-08-01 00:00:00

  • Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model.

    abstract:OBJECT:The purpose of this study was to evaluate both replication-competent and replication-restricted recombinant vesicular stomatitis virus (VSV) vectors as therapeutic agents for high-grade gliomas by using an organotypic brain tissue slice-glioma coculture system. METHODS:The coculture system involved growing diff...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.100.6.1049

    authors: Duntsch CD,Zhou Q,Jayakar HR,Weimar JD,Robertson JH,Pfeffer LM,Wang L,Xiang Z,Whitt MA

    更新日期:2004-06-01 00:00:00

  • Surgical treatment of patients with vestibular schwannomas after failed previous radiosurgery.

    abstract:OBJECT:An increasing number of patients with vestibular schwannomas (VSs) are being treated with radiosurgery. Treatment failure or secondary regrowth after radiosurgery, however, has been observed in 2%-9% of patients. In large tumors that compress the brainstem and in patients who experience rapid neurological deteri...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.12.JNS111682

    authors: Gerganov VM,Giordano M,Samii A,Samii M

    更新日期:2012-04-01 00:00:00

  • Immunobiology of primary intracranial tumors. Part 4: levamisole as an immune stimulant in patients and in the ASV glioma model.

    abstract::Levamisole was evaluated as an immune stimulant in a randomized controlled study of patients with anaplastic gliomas, who had undergone surgical resection and who were also treated with radiotherapy and BCNU chemotherapy. Of 102 patients placed into the study, 85 were determined to comprise the adequately treated grou...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3171/jns.1981.54.2.0220

    authors: Mahaley MS Jr,Steinbok P,Aronin P,Dudka L,Zinn D

    更新日期:1981-02-01 00:00:00

  • Engorged epidural venous plexus and cervical myelopathy due to cerebrospinal fluid overdrainage: a rare complication of ventricular shunts. Case report.

    abstract::The authors report on a 17-year-old boy with cervical myelopathy from dilated epidural veins due to cerebrospinal fluid (CSF) overdrainage. The patient had a long-standing subdural-peritoneal shunt and presented with incapacitating spastic tetraparesis. Magnetic resonance imaging revealed significant cervical spinal c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2007.106.3.227

    authors: Wolfe SQ,Bhatia S,Green B,Ragheb J

    更新日期:2007-03-01 00:00:00

  • Somatic IDH1 mutation in a pituitary adenoma of a patient with Maffucci syndrome.

    abstract::Maffucci syndrome is a rare disease characterized by multiple enchondromas and soft-tissue hemangiomas. Additionally, neuroendocrine tumors including pituitary adenomas have been described in these patients. The underlying genetic etiology lies in somatic mosaicism of mutations in isocitrate dehydrogenase 1 (IDH1) or ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.4.JNS15191

    authors: Hao S,Hong CS,Feng J,Yang C,Chittiboina P,Zhang J,Zhuang Z

    更新日期:2016-06-01 00:00:00

  • Endoscopic repair of cerebrospinal fluid leaks in the lateral sphenoid sinus recess.

    abstract:OBJECT:Cerebrospinal fluid leaks may occur as a result of trauma or following surgery, and occasionally may also be spontaneous. Leakage of CSF from the lateral sphenoid recess is rare and challenging to treat. The authors present their experience with repairs of 10 CSF leaks that were confined to the lateral sphenoid ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.7.JNS09306

    authors: Forer B,Sethi DS

    更新日期:2010-02-01 00:00:00

  • Role of endothelin in pial artery vasoconstriction and altered responses to vasopressin after brain injury.

    abstract::Pial artery constriction following fluid-percussion injury to the brain is associated with elevated cerebrospinal fluid (CSF) vasopressin concentration in newborn pigs. It has also been observed that fluid-percussion injury reverses the function of vasopressin from that of a dilator to a constrictor. Endothelin-1 (ET-...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.5.0901

    authors: Armstead WM

    更新日期:1996-11-01 00:00:00

  • Comparative anatomical analysis between the minipterional and supraorbital approaches.

    abstract:OBJECTIVE:Keyhole approaches, namely the minipterional approach (MPTa) and the supraorbital approach (SOa), are alternatives to the standard pterional approach to treat lesions located in the anterior and middle cranial fossae. Despite their increasing popularity and acceptance, the indications and limitations of these...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.12.JNS193196

    authors: Martínez-Pérez R,Albonette-Felicio T,Hardesty DA,Prevedello DM

    更新日期:2020-03-13 00:00:00

  • Dotlike hemosiderin spots on T2*-weighted magnetic resonance imaging as a predictor of stroke recurrence: a prospective study.

    abstract:OBJECT:Microangiopathy associated with hypertension is a notable cause of cerebral small vessel disease (SVD), including deep intracerebral hemorrhage (ICH) and lacunar infarct. Dotlike low-intensity spots (dotlike hemosiderin spots: dotHSs) on T2*-weighted magnetic resonance (MR) images have been histologically diagno...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2004.101.6.0915

    authors: Imaizumi T,Horita Y,Hashimoto Y,Niwa J

    更新日期:2004-12-01 00:00:00

  • Magnetic resonance imaging of obliterated arteriovenous malformations up to 23 years after radiosurgery.

    abstract::The authors report outcomes in 18 patients with arteriovenous malformations (AVMs) who were treated with gamma knife radiosurgery and in whom magnetic resonance (MR) imaging was obtained a mean of 14 years (range 8-23 years) after treatment and 10 years (range 4-17 years) after confirmed obliteration of the AVM. All p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.86.4.0589

    authors: Kihlström L,Guo WY,Karlsson B,Lindquist C,Lindqvist M

    更新日期:1997-04-01 00:00:00

  • Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease.

    abstract:OBJECT:Glial cell line-derived neurotrophic factor (GDNF) has been shown to confer neuroprotective effects on dopaminergic neurons. The authors investigated the effects of GDNF on 6-hydroxydopamine (6-OHDA)-treated dopaminergic neurons in vitro and in vivo. METHODS:First, the authors examined how 1, 10, or 100 ng/ml o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.1.0080

    authors: Yasuhara T,Shingo T,Muraoka K,Kobayashi K,Takeuchi A,Yano A,Wenji Y,Kameda M,Matsui T,Miyoshi Y,Date I

    更新日期:2005-01-01 00:00:00

  • Treatment by specialist surgical neurooncologists improves survival times for patients with malignant glioma.

    abstract:OBJECT:Surgeries for CNS tumors are frequently performed by general neurosurgeons and by those who specialize in surgical neurooncology. Subspecialization in neurosurgical practice has become common and may improve patient morbidity and mortality rates. However, the potential benefits for patients of having their surge...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS132057

    authors: Khan UA,Bhavsar A,Asif H,Karabatsou K,Leggate JR,Sofat A,Kamaly-Asl ID

    更新日期:2015-02-01 00:00:00

  • Invading meningiomas of the sphenoid ridge.

    abstract::The authors report a series of 34 meningiomas of the sphenoid ridge. Eight tumors were totally removed uneventfully: two from the middle sphenoid ridge and six from the pterion or Sylvian point. Five tumors were not operated on because of their extensions or the patient's age. Twenty-one tumors raised serious surgical...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.5.0587

    authors: Bonnal J,Thibaut A,Brotchi J,Born J

    更新日期:1980-11-01 00:00:00

  • Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma.

    abstract:OBJECT:The differentiation of malignant lymphomas from gliomas or malignant gliomas by conventional MRI can be difficult. The authors studied Gd-enhanced MR images to obtain a differential diagnosis between malignant lymphomas and gliomas without central necrosis or cystic changes and investigated the diagnostic value ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.9.JNS14106

    authors: Yamasaki F,Takayasu T,Nosaka R,Amatya VJ,Doskaliyev A,Akiyama Y,Tominaga A,Takeshima Y,Sugiyama K,Kurisu K

    更新日期:2015-06-01 00:00:00