Abstract：
:A double-blind crossover volunteer trial has been carried out to determine if oral doxapram reduces the respiratory depression caused by morphine 0.12 mg kg-1 i.m. Doxapram was given to the subjects 90 min before the morphine and significantly reduced the displacement of the ventilatory response to carbon dioxide caused by the morphine. This occurred despite the fact that the plasma concentrations of doxapram were significantly lower when the subject had been given morphine than when a placebo injection had been administered. Doxapram alone in doses of 300 mg and 600 mg did not alter significantly the respiratory variables measured in this study.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Randall NP,Pleuvry BJ,Fazackerley EJ,Modla CY,Prescott LF,Healy TEdoi
10.1093/bja/62.2.159subject
Has Abstractpub_date
1989-02-01 00:00:00pages
159-63issue
2eissn
0007-0912issn
1471-6771pii
S0007-0912(17)47439-3journal_volume
62pub_type
临床试验,杂志文章,随机对照试验abstract：:The kinetics of morphine were studied during balanced anaesthesia in 10 patients undergoing lower abdominal or body surface surgery, and compared with those obtained in nine awake patients receiving morphine i.v. for the relief of chronic non-cancer pain. All patients received morphine sulfphate pentahydrate 10 mg i.v...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.1.22
更新日期：1989-01-01 00:00:00
abstract：:The effects of doxacurium chloride, a new long-acting non-depolarizing neuromuscular blocking drug, on cardiac performance were studied in 45 patients undergoing high-dose fentanyl-diazepam-oxygen anaesthesia for cardiac surgery. Data were collected at baseline (10 min after tracheal intubation), and at 2, 5 and 10 mi...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/63.6.675
更新日期：1989-12-01 00:00:00
abstract：:The pupils in brainstem-dead patients are classically fixed and dilated. We present a case of a brainstem-dead patient whose pupils displayed persistent asynchronous pupillary constriction and dilatation independent of external physical stimuli. Central causes for the phenomenon were excluded leaving an unexplained pe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/86.5.717
更新日期：2001-05-01 00:00:00
abstract：:Six male patients were studied on the morning following upper abdominal surgery for highly selective vagotomy. Nalbuphine hydrochloride was infused i.v. at different rates that increased progressively in each hour over a 4-h period. In the last 15 min of each hour, the plasma nalbuphine concentrations were almost stea...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.11.1356
更新日期：1987-11-01 00:00:00
abstract：:The effect of prostaglandin E1 (PGE1) on local cerebral blood flow (LCBF) and carbon dioxide reactivity (CO2R) was studied during cerebral aneurysm surgery for subarachnoid haemorrhage in 24 patients under neuroleptanaesthesia. Eleven patients had good neurological status (Hunt and Kosnik grade I: group A) and 13 pati...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.3.268
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:Target-controlled infusion (TCI) systems use pharmacokinetic (PK) models to predict the drug infusion rates necessary to achieve a desired target plasma or effect-site concentration. As new PK models are developed and implemented in TCI systems, there can be uncertainty as to which target concentrations are ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.05.051
更新日期：2020-10-01 00:00:00
abstract：:Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/63.5.536
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Several medications have proved to be useful in preventing postoperative nausea and vomiting (PONV). However, routine antiemetic prophylaxis is not cost-effective. We evaluated the accuracy and discriminating power of an artificial neural network (ANN) to predict PONV. METHODS:We analysed data from 1086 in-...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/ael282
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients after major surgery. An association between POCD and the development of dementia has been suspected. In this study, we assessed if POCD was a risk factor for the occurrence of dementia. METHODS:Danish patients enrolled b...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,多中心研究
doi：10.1093/bja/aes466
更新日期：2013-06-01 00:00:00
abstract：:We present a new pattern of nerve stimulation--double burst stimulation (DBS)--to detect residual neuromuscular block manually. The DBS consists of two short lasting, 50-Hz tetanic stimuli or bursts separated by a 750-ms interval. The response to this pattern of stimulation is two single separated muscle contractions ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.3.274
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:The properties of methadone suggest a potential advantage for epidural over i.v. administration for pain relief, but little supportive evidence exists. METHODS:To investigate the pharmacokinetic and the pharmacodynamic properties of epidural and i.v. methadone, four doses of methadone (0.1, 0.25, 0.5, and 0...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet234
更新日期：2014-01-01 00:00:00
abstract：:Prolongation of the QT interval of the ECG represents an imbalance in cardiac autonomic function and may predict cardiac arrhythmia. Vagal activity protects against prolongation of the QT interval which may be associated with flattening of the T-wave of the ECG. The changes in QT interval, T-wave amplitude and respira...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/71.5.736
更新日期：1993-11-01 00:00:00
abstract：:We describe a scavenging device, primarily for use during inhalation induction of anaesthesia in children; it was designed to optimize the often conflicting requirements of clinical acceptability and adequate gas collection. The performance was assessed in three ways. The device reduced the nitrous oxide concentration...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/64.1.117
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The 15-item Quality of Recovery (QoR-15) scale is a validated patient-reported outcome questionnaire that measures the quality of postoperative recovery. This study aimed to validate a translated Korean version of QoR-15 (QoR-15K) in a broad range of surgical patients. METHODS:After Korean translation of th...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.06.040
更新日期：2020-10-01 00:00:00
abstract：:A new method has been developed to measure end-tidal carbon dioxide partial pressure (PECO2) during high frequency jet ventilation (HFJV). A digital flow controller incorporated in a computerized high frequency jet ventilator was used to deliver either a single deep breath or a series of three deep breaths. On user re...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/63.7.47
更新日期：1989-01-01 00:00:00
abstract：:We studied the effects of minor surgery and endotracheal intubation on postoperative breathing patterns. We measured breathing patterns and laryngeal resistance during the periods immediately before intubation (preoperative) and immediately after extubation following minor surgery (postoperative) in eight patients ana...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/87.5.706
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Desflurane at more than 1 minimum alveolar concentration (MAC) has been shown to prolong the QT interval, but it is unclear whether this is the case at lower concentrations. The aim of this study was to determine whether desflurane concentrations of <1 MAC affect tracheal intubation-induced prolongation of t...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aep355
更新日期：2010-02-01 00:00:00
abstract：:Since the preoperative administration of water might promote gastric emptying and dilute the remaining gastric contents, 50 patients were investigated before elective surgery. One group was given water 100 ml 2 h before operation; the other group was fasted as usual. Volume and pH of gastric contents were measured imm...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/60.7.803
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:Clonidine is an alpha 2 adrenergic agonist with analgesic properties. This study aimed to see if the addition of clonidine to morphine when given by patient-controlled analgesia (PCA) would improve analgesia beyond the first 12 h after surgery. METHODS:Sixty patients undergoing lower abdominal surgery were ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Endothelial dysfunction might be involved in the development of cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH). METHODS:This prospective observational study of 48 SAH subjects and 23 control subjects examined associations between reactive hyperaemia index (RHI) measured by peripheral art...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet331
更新日期：2014-02-01 00:00:00
abstract：:Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies. A high-concentration capsaicin 8% patch (Qutenza™) was recently approved in the EU a...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aer260
更新日期：2011-10-01 00:00:00
abstract：:We have compared iontophoretically and locally applied lidocaine for relief of pain on propofol injection. Pain was assessed on insertion of a 20-gauge i.v. cannula and at 10-s intervals for 30 s after injection of propofol. Pain scores on cannulation were significantly less in the iontophoresis group (median 1.1) tha...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/82.3.432
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Tracheal tube tip and cuff positions of different cuffed paediatric tracheal tube brands in the trachea can vary with design. METHODS:Data from three clinical studies with measured tracheal lengths were pooled in a database including 422 children aged from birth to 16 yr. Dimensional data of seven cuffed pa...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2018.05.002
更新日期：2018-08-01 00:00:00
abstract：:We investigated in 60 patients scheduled for elective aorto-coronary bypass grafting if loud sounds by themselves can induce cardiovascular responses and if these could be related to mid-latency auditory evoked potentials (MLAEP). Anaesthesia was induced in group I (n = 20) with flunitrazepam-fentanyl 0.01 mg kg-1 and...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/72.3.307
更新日期：1994-03-01 00:00:00
abstract：:The accuracy of five new oxygen and nitrous oxide flowmeter units was investigated using the bubble meter method. The results were compared with those previously found in flowmeters withdrawn from clinical use. New oxygen flowmeters demonstrated less inaccuracies than old flowmeters. No differences were found between ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.1.97
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:Pressure recording analytical method (PRAM) is a novel, arterial pulse contour-based method for measuring cardiac output (CO). Validation studies of PRAM in children are few, and have not assessed both absolute accuracy and ability to track changes in CO across a broad case mix. We aimed to compare CO as mea...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aes420
更新日期：2013-03-01 00:00:00
abstract：:We have studied the effects of alcuronium in 10 healthy, non-anaesthetized volunteers after they had been taking oral pyridostigmine 30 mg 8 hourly. The responses of adductor pollicis were recorded using an isolated forearm procedure (IFP) during onset and recovery of neuromuscular block produced by 1.5 mg of relaxant...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/66.3.365
更新日期：1991-03-01 00:00:00
abstract：:We calculated oxygen consumption by the reverse Fick principle (cVO2) using cardiac output measured with a new technique of continuous thermal dilution and compared these values with measurements made at the same time using a gas exchange method (mVO2). We studied nine patients in a stable condition after cardiac surg...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/75.6.719
更新日期：1995-12-01 00:00:00
abstract：:Three anaesthetic techniques based on isoflurane were compared in outpatients undergoing laparoscopy. Sixty healthy patients were randomly allocated to receive isoflurane via mask (spontaneous respiration), via tracheal tube (spontaneous respiration) or via tracheal tube with controlled ventilation. Moderate hypercarb...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/59.2.189
更新日期：1987-02-01 00:00:00
abstract：BACKGROUND:Lidocaine is frequently used as an agent to treat ventricular arrhythmias associated with acute myocardial ischaemia. Lidocaine is a potent blocker not only of sodium channels, but also of ATP-sensitive potassium channels. The opening of these channels is a key mechanism of ischaemic preconditioning. We inve...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh262
更新日期：2004-11-01 00:00:00
