Susceptibilities of bacterial and fungal urinary tract isolates to desferrioxamine.

abstract：:An in vitro model of monocyte-derived dendritic cells (MO-DC) and CD4(+) T cells, representing the primary targets of sexual human immunodeficiency virus (HIV) transmission, was used to evaluate the antiviral and immune suppressive activity of new classes of nonnucleoside reverse transcriptase inhibitors, diaryltriazi...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Herrewege Y,Vanham G,Michiels J,Fransen K,Kestens L,Andries K,Janssen P,Lewi P

更新日期：2004-10-01 00:00:00

abstract：:Pradimicin S (PRM-S) is a highly water-soluble, negatively charged derivative of the antibiotic pradimicin A (PRM-A) in which the terminal xylose moiety has been replaced by 3-sulfated glucose. PRM-S does not prevent human immunodeficiency virus (HIV) adsorption on CD4(+) T cells, but it blocks virus entry into its ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Balzarini J,François KO,Van Laethem K,Hoorelbeke B,Renders M,Auwerx J,Liekens S,Oki T,Igarashi Y,Schols D

更新日期：2010-04-01 00:00:00

abstract：:An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region w...

journal_title：Antimicrobial agents and chemotherapy

authors： Janvier F,Jeannot K,Tessé S,Robert-Nicoud M,Delacour H,Rapp C,Mérens A

更新日期：2013-07-01 00:00:00

abstract：:Peroxide antimalarials, including artemisinin, are important for the treatment of multidrug-resistant malaria. These peroxides are known to react with iron or heme to produce reactive intermediates that are thought to be responsible for their antimalarial activities. This study investigated the potential interaction o...

journal_title：Antimicrobial agents and chemotherapy

authors： Creek DJ,Ryan E,Charman WN,Chiu FC,Prankerd RJ,Vennerstrom JL,Charman SA

更新日期：2009-08-01 00:00:00

abstract：:Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metab...

journal_title：Antimicrobial agents and chemotherapy

authors： Hufford CD,Baker JK,McChesney JD,Clark AM

更新日期：1986-08-01 00:00:00

abstract：:The efficacies of cilofungin and amphotericin B separately and together in mice with disseminated candidiasis were studied. Male CD-1 mice (age, 5 weeks) were infected intravenously with 3 X 10(5) CFU of Candida albicans. At 4 days postinfection, intraperitoneal therapy was initiated and was continued for 14 days. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Hanson LH,Perlman AM,Clemons KV,Stevens DA

更新日期：1991-07-01 00:00:00

abstract：:KBP-7072 is a novel aminomethylcycline antibiotic in clinical development for community-acquired pneumonia. The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the murine pneumonia infection model against Staphylococcus aureus and S...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Liu Q,Wang P,Wang Y,Bader JC,Ambrose PG,Andes DR

更新日期：2019-02-26 00:00:00

abstract：:The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC beta-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC...

journal_title：Antimicrobial agents and chemotherapy

authors： Okamoto K,Gotoh N,Nishino T

更新日期：2002-08-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:The in vitro susceptibilities of 112 clinical isolates of Haemophilus ducreyi to six antimicrobial agents were determined. These isolates were obtained in Kigali, Rwanda, during three studies on genital ulcer disease performed in 1986 (18 isolates), 1988 (23 isolates), and 1991 (71 isolates). All H. ducreyi isolates w...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Dyck E,Bogaerts J,Smet H,Tello WM,Mukantabana V,Piot P

更新日期：1994-07-01 00:00:00

abstract：:Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

journal_title：Antimicrobial agents and chemotherapy

authors： Heifets L,Sanchez T,Vanderkolk J,Pham V

更新日期：1999-01-01 00:00:00

abstract：:We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming ...

journal_title：Antimicrobial agents and chemotherapy

authors： D'Souza R,Pinto NA,Higgins PG,Hwang I,Yong D,Choi J,Lee K,Chong Y

更新日期：2017-04-24 00:00:00

abstract：:Rifabutin pharmacokinetics were studied by the population approach (NONMEM) with 40 human immunodeficiency virus-infected patients receiving rifabutin at different doses for prophylaxis or therapy of mycobacterial infections. A two-compartment open model with first-order absorption was used as the structural pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Papa P,Torre D,Andreoni M,Poggio A,Bassetti M,Marone P

更新日期：1998-08-01 00:00:00

abstract：:3-Deazauridine, a synthetic analogue of uridine and a potential antitumor agent, was found to possess antiviral activity against a number of ribonucleic acid-containing animal viruses in mammalian cell culture. Inhibition of virus-induced cytopathogenic effects by 3-deazauridine was observed in cells infected with rhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Shannon WM,Arnett G,Schabel FM Jr

更新日期：1972-09-01 00:00:00

abstract：:The density of the biofilm layer produced on a plastic surface by 23 clinical isolates and 1 reference strain of slime-positive, coagulase-negative staphylococci was measured following growth in subinhibitory concentrations (sub-MICs) of cefamandole or vancomycin ranging from 2 to 0.008 micrograms/ml. All strains were...

journal_title：Antimicrobial agents and chemotherapy

authors： Dunne WM Jr

更新日期：1990-03-01 00:00:00

abstract：:Clinical treatment failures have been reported to occur in early Lyme borreliosis (LB) for many suitable antimicrobial agents. Investigations of possible resistance mechanisms of the Borrelia burgdorferi complex must analyze clinical isolates obtained from LB patients, despite their receiving antibiotic treatment. Her...

journal_title：Antimicrobial agents and chemotherapy

authors： Hunfeld KP,Ruzic-Sabljic E,Norris DE,Kraiczy P,Strle F

更新日期：2005-04-01 00:00:00

abstract：:Telavancin displays potent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA), including strains with reduced susceptibility to vancomycin. We compared the efficacies of telavancin and vancomycin against MRSA strains with vancomycin MICs of ≥1 μg/ml in a neutropenic murine lung in...

journal_title：Antimicrobial agents and chemotherapy

authors： Crandon JL,Kuti JL,Nicolau DP

更新日期：2010-12-01 00:00:00

abstract：:In our study we examined the anti-human immunodeficiency virus type 1 (anti-HIV-1) activity of a novel HIV-1 protease inhibitor, PNU-140690 (tipranavir), against patient-derived isolates resistant to multiple other protease inhibitors (PIs). The aim of our experiments was to investigate the genotypes and the in vitro ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rusconi S,La Seta Catamancio S,Citterio P,Kurtagic S,Violin M,Balotta C,Moroni M,Galli M,d'Arminio-Monforte A

更新日期：2000-05-01 00:00:00

abstract：:The in vitro activity of OPC-17116, a new C-5 methyl fluoroquinolone, was compared with the activities of other fluoroquinolones. OPC-17116 inhibited 50% of the members of the family Enterobacteriaceae tested and 90% of Haemophilus influenzae, Neisseria species, and Moraxella catarrhalis isolates at less than or equal...

journal_title：Antimicrobial agents and chemotherapy

authors： Neu HC,Fang W,Gu JW,Chin NX

更新日期：1992-06-01 00:00:00

abstract：:Kill-kinetic methods were used to provide data on the bactericidal activity of subinhibitory (0.5x MIC), inhibitory (1x MIC), and suprainhibitory (4x MIC) concentrations of LY146032 against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis. These bactericidal activities were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Liu C,Weeks LS

更新日期：1987-08-01 00:00:00

abstract：:The minimal inhibitory concentration of temocillin (BRL 17421) against 476 clinical isolates was determined by an agar dilution method. Temocillin was active against most of the Enterobacteriaceae, Haemophilus, and Neisseria strains tested. The compound showed low activity or was inactive against Bacteroides, Campylob...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Landuyt HW,Pyckavet M,Lambert A,Boelaert J

更新日期：1982-10-01 00:00:00

abstract：:Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluc...

journal_title：Antimicrobial agents and chemotherapy

authors： Chau AS,Chen G,McNicholas PM,Mann PA

更新日期：2006-11-01 00:00:00

abstract：:Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i.e., the period when...

journal_title：Antimicrobial agents and chemotherapy

authors： Legrand E,Yrinesi J,Ekala MT,Péneau J,Volney B,Berger F,Bouchier C,Bertani S,Musset L,Meynard JB,Mercereau-Puijalon O

更新日期：2012-03-01 00:00:00

abstract：:Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants that survived were identified by transposon sequencing (Tn-Seq). We determined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Molina-Quiroz RC,Lazinski DW,Camilli A,Levy SB

更新日期：2016-10-21 00:00:00

abstract：:There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing sign...

journal_title：Antimicrobial agents and chemotherapy

authors： Todd DA,Parlet CP,Crosby HA,Malone CL,Heilmann KP,Horswill AR,Cech NB

更新日期：2017-07-25 00:00:00

abstract：:A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002. Species identification was confirmed by standard biochemical tests and analysis of 16S ribosomal DNA, gyrA, and gyrB sequences; all of the results were consistent with the S. aureus identification...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenover FC,Weigel LM,Appelbaum PC,McDougal LK,Chaitram J,McAllister S,Clark N,Killgore G,O'Hara CM,Jevitt L,Patel JB,Bozdogan B

更新日期：2004-01-01 00:00:00

abstract：:Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

journal_title：Antimicrobial agents and chemotherapy

authors： Escamilla J

更新日期：1976-01-01 00:00:00

abstract：:T-8581 is a new water-soluble triazole antifungal agent. The geometric mean IC80s (GM-IC80S; where the IC80 is the lowest drug concentration which reduced the optical density at 630 nm by 80% compared with the optical density at 630 nm of the drug-free control) for Candida albicans were as follows: T-8581, 0.218 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Yotsuji A,Shimizu K,Araki H,Fujimaki K,Nishida N,Hori R,Annen N,Yamamoto S,Hayakawa H,Imaizumi H,Watanbe Y,Narita H

更新日期：1997-01-01 00:00:00

abstract：:The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, n...

journal_title：Antimicrobial agents and chemotherapy

authors： Staehli Hodel EM,Csajka C,Ariey F,Guidi M,Kabanywanyi AM,Duong S,Decosterd LA,Olliaro P,Beck HP,Genton B

更新日期：2013-02-01 00:00:00

abstract：:Monobactams containing 3 beta-aminothiazolyl oxime side chains (SQ 81,377, SQ 81,402, azthreonam, and SQ 26,917) have poor affinities for the broad-spectrum beta-lactamases TEM-2 and K1. Addition of a 4-methyl substituent significantly increased stability to hydrolysis by these enzymes. P99 cephalosporinase from Enter...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Freudenberger JS,Sykes RB

更新日期：1982-09-01 00:00:00