Abstract：
OBJECTIVE:The purpose of this study was to examine the relationship between verbal learning and memory performance and hippocampal volume in subjects with co-morbid type 2 diabetes and major depression compared with healthy control subjects and subjects with type 2 diabetes alone. METHODS:Twenty four subjects with type 2 diabetes and 20 subjects with type 2 diabetes and major depression were recruited from endocrinology clinics and were compared with 32 healthy control subjects recruited from the community. Subjects were scanned on a 1.5 T GE scanner, and hippocampal volumes were measured using Freesurfer. The California Verbal Learning Test assessed learning and memory. Significant predictors of verbal learning performance (e.g., age, gender, education, blood pressure, stroke risk, hemoglobin A1c, and hippocampal volume) were determined using a stepwise linear regression. RESULTS:Subjects with diabetes and depression had significantly worse performance on verbal list learning compared with healthy control subjects. Hippocampal volume was a strong predictor of performance in healthy control subjects, and age and hippocampal volume were strong predictors in subjects with type 2 diabetes alone. Age alone was a significant predictor of verbal learning performance in subjects with diabetes and depression. CONCLUSIONS:The relationship between hippocampal volume and performance on the California Verbal Learning Test is decoupled in subjects with type 2 diabetes and major depression and this decoupling may contribute to poor verbal learning and memory performance in this study population.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Ajilore O,Lamar M,Medina J,Watari K,Elderkin-Thompson V,Kumar Adoi
10.1002/gps.4149subject
Has Abstractpub_date
2015-04-01 00:00:00pages
393-9issue
4eissn
0885-6230issn
1099-1166journal_volume
30pub_type
杂志文章abstract：OBJECTIVE:To find a blood biomarker and disease-related peptides in Alzheimer's disease (AD), we comprehensively detected serum peptides. METHODS:Ion intensity of serum peptides from 62 AD patients and 82 control subjects was measured by mass spectrometry. RESULTS:A total of 157 peptides were detected from 30 AD pati...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4047
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To consider the characteristics of first episode psychosis in older adults in a county in North East England. METHOD/DESIGN:The present study used a naturalistic design to compare individuals aged 65 years and over with those under 65, with a first episode psychosis. Data were collected on demographics, diag...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2437
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:We aimed to assess the effect of socioeconomic status and physical activity on cognitive function using a large population-based survey data in China. METHODS:We took advantage of the Chinese Longitudinal Healthy Longevity Survey conducted in 2014 to examine the relationship between sociodemographic, physica...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:This study evaluated the impact of an eight-session training program for aged care staff in managing dementia-related challenging behaviours. Participation in the training program with an additional five-session peer support group was compared with both participation in training only and a wait-list control c...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1754
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:In order to study secular changes in personality factors neuroticism and extroversion, representative population samples of non-demented 75-year-olds underwent psychiatric examinations in 1976-1977 (total n = 223, 138 women, 85 men) and 2005-2006 (total n = 556, 322 women and 234 men). METHODS:Eysenck Person...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.3825
更新日期：2013-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1872
更新日期：2008-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5200
更新日期：2019-12-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4452
更新日期：2017-02-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1138
更新日期：2004-07-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.448
更新日期：2001-11-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.3812
更新日期：2013-02-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2325
更新日期：2010-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199802)13:2<109::aid-gps74
更新日期：1998-02-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1556
更新日期：2006-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.1803
更新日期：2007-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/1099-1166(200011)15:11<1009::aid-gps228>3.
更新日期：2000-11-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2833
更新日期：2012-11-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.2650
更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199705)12:5<526::aid-gps53
更新日期：1997-05-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-02-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2331
更新日期：2010-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
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更新日期：2012-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2416
更新日期：2010-07-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.2210
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVES:Insulin resistance is a substantial health issue for American Indians, with type 2 diabetes overrepresented in this population as compared with non-Hispanic whites. Insulin resistance and its related conditions in turn increase risk for dementia and cognitive impairment. The aim of the current study was to d...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5108
更新日期：2019-07-01 00:00:00
