Influence of stromal-epithelial interactions on androgen action.

Abstract:

:Androgen receptor (AR) signaling is vital to the development and function of the prostate and is a key pathway in prostate cancer. AR is differentially expressed in the stroma and epithelium, with both paracrine and autocrine control throughout the prostate. Stromal-epithelial interactions within the prostate are commonly dependent on AR signaling and expression. Alterations in these pathways can promote tumorigenesis. AR is also expressed in normal and malignant mammary tissues. Emerging data indicate a role for AR in certain subtypes of breast cancer that has the potential to be exploited therapeutically. The aim of this review is to highlight the importance of these interactions in normal development and tumorigenesis, with a focus on the prostate and breast.

journal_name

Endocr Relat Cancer

journal_title

Endocrine-related cancer

authors

Nieto CM,Rider LC,Cramer SD

doi

10.1530/ERC-14-0138

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

T147-60

issue

4

eissn

1351-0088

issn

1479-6821

pii

ERC-14-0138

journal_volume

21

pub_type

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