Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1.

Abstract:

:Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase gene family that contributes to the invasiveness and metastasis in tumor progression. However, the role of LOXL2 in cellular signaling is incompletely understood. In this study, we investigated a possible mechanism of LOXL2 function in tumor metastases in vitro, using a human breast carcinoma cell line. Myristoylated alanine-rich C kinase substrate-like 1 (MARCKSL1), a modulator in the regulation of cellular homeostasis, was identified as a LOXL2 interacting protein. We examined the binding domains that are required for the interaction between LOXL2 and MARCKSL1. The scavenger-receptor domain of LOXL2 was shown to interact with the N-terminal domain of MARCKSL1. Luciferase activity was noticeably reduced by the transfection of MARCKSL1 in a dose-dependent manner. In addition, over-expression of LOXL2 activates cell growth by inhibiting MARCKSL1-induced apoptosis. The effect of LOXL2 on cell cycle and apoptosis-related components was also confirmed through the silencing of LOXL2 expression. LOXL2 activates the FAK/Akt/mTOR signaling pathways, and MARCKSL1 suppresses LOXL2-induced oncogenesis. These insights supply evidence that LOXL2 promotes cell proliferation and inhibits apoptotic cell death. Taken together, our results indicate an underlying mechanism for an increase of LOXL2-related activity in breast tumor cells.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Kim BR,Dong SM,Seo SH,Lee JH,Lee JM,Lee SH,Rho SB

doi

10.1016/j.cellsig.2014.05.010

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1765-73

issue

9

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(14)00180-6

journal_volume

26

pub_type

杂志文章
  • Modulation of neutrophil phospholipase C activity and cyclic AMP levels by fMLP-OMe analogues.

    abstract::The N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-OMe (1) analogues for-Thp-Leu-Ain-OMe (2), for-Thp-Leu-Phe-OMe (3), for-Met-Leu-Ain-OMe (4), for-Met-Delta(z)Leu-Phe-OMe (5), for-Met-Lys-Phe-For-Met-Lys-Phe (6), for-Met-Leu-Pheol-COMe (7), and for-Nle-Leu-Phe-OMe (8) have been studied. Some of these have been ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/s0898-6568(01)00140-1

    authors: Ferretti ME,Nalli M,Biondi C,Colamussi ML,Pavan B,Traniello S,Spisani S

    更新日期:2001-04-01 00:00:00

  • Selective down-regulation of angiotensin II receptor type 1A signaling by protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells.

    abstract::The heptahelical AT(1) G-protein-coupled receptor lacks inherent tyrosine kinase activity. Angiotensin II binding to AT(1) nevertheless activates several tyrosine kinases and stimulates both tyrosine phosphorylation and phosphatase activity of the SHP-2 tyrosine phosphatase in vascular smooth muscle cells. Since a bal...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2003.08.001

    authors: Doan T,Farmer P,Cooney T,Ali MS

    更新日期:2004-03-01 00:00:00

  • Factors affecting prostacyclin receptor agonist efficacy in different cell types.

    abstract::Octimibate and related nonprostanoid prostacyclin mimetics are partial agonists displaying highly tissue-specific responses. Octimibate demonstrated considerably greater efficacy for stimulation of adenylyl cyclase activity in Chinese hamster ovary cells transiently expressing mouse prostacyclin receptors (mIP-CHO cel...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/s0898-6568(01)00210-8

    authors: Kam Y,Chow KB,Wise H

    更新日期:2001-11-01 00:00:00

  • Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake.

    abstract::Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2009.01.022

    authors: Illario M,Monaco S,Cavallo AL,Esposito I,Formisano P,D'Andrea L,Cipolletta E,Trimarco B,Fenzi G,Rossi G,Vitale M

    更新日期:2009-05-01 00:00:00

  • Changes in intracellular cAMP reported by a Redistribution assay using a cAMP-dependent protein kinase-green fluorescent protein chimera.

    abstract::We report on a novel method to monitor changes in intracellular cAMP concentration ([cAMP]i) within intact living cells using a chimeric fusion of the catalytic subunit of cAMP-dependent protein kinase to green fluorescent protein (PKAcat-GFP). In stably transfected unstimulated fibroblasts, fusion protein fluorescenc...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2004.01.006

    authors: Almholt K,Tullin S,Skyggebjerg O,Scudder K,Thastrup O,Terry R

    更新日期:2004-08-01 00:00:00

  • The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells.

    abstract::Lysophosphatidic acid (LPA) plays a critical role in the pathophysiology of ovarian cancers. Previous studies have shown that LPA stimulates the proliferation of ovarian cancer cells via Gα12. The present study utilizing Protein/DNA array analyses of LPA-stimulated HeyA8 cells in which the expression of Gα12 was silen...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2013.08.012

    authors: Ha JH,Ward JD,Varadarajalu L,Kim SG,Dhanasekaran DN

    更新日期:2014-01-01 00:00:00

  • Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes.

    abstract::Non-alcoholic fatty liver disease is the most commonly occurring chronic liver disease, and hepatic steatosis, a condition defined as extensive lipid accumulation in hepatocytes, is associated with liver dysfunction and metabolic diseases, such as, obesity and type II diabetes. Apelin is an adipokine that acts on a G ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2017.08.003

    authors: Huang J,Kang S,Park SJ,Im DS

    更新日期:2017-11-01 00:00:00

  • Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

    abstract::Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N morphologically resembles inflammation-inducing pyroptosis - cell destruction triggered by activated caspase-1. The treatment with A + N (or camptothecin) strongly upregulat...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109552

    authors: Krześniak M,Zajkowicz A,Gdowicz-Kłosok A,Głowala-Kosińska M,Łasut-Szyszka B,Rusin M

    更新日期:2020-05-01 00:00:00

  • Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.

    abstract::Metformin, the most used drug for the treatment of diabetes type 2 patients, has been shown to have anti-cancer properties. In this study, we found that metformin induced apoptosis in Primary Effusion Lymphoma (PEL) cells, an aggressive B cell lymphoma associated with KSHV against which the conventional therapies usua...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2017.09.020

    authors: Granato M,Gilardini Montani MS,Romeo MA,Santarelli R,Gonnella R,D'Orazi G,Faggioni A,Cirone M

    更新日期:2017-12-01 00:00:00

  • Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549.

    abstract::Stathmin is overexpressed in a variety of assessed human malignancies and is correlated with tumor progression and poor prognosis. Downregulation of its expression will contribute to optimize therapeutic outcomes in the treatment of various malignancies. However, the mechanisms of stathmin gene overexpression are not ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2009.09.030

    authors: Fang L,Min L,Lin Y,Ping G,Rui W,Ying Z,Xi W,Ting H,Li L,Ke D,Jihong R,Huizhong Z

    更新日期:2010-01-01 00:00:00

  • Altered signal pathway in angiotensin II-stimulated neutrophils of patients with hypercholesterolaemia.

    abstract::Angiotensin II (AII) in 1-10 nM concentrations has an in vivo immunostimulating effect on human neutrophils. The release of superoxide anions and leukotrienes (LTs) is significantly increased by 10 nM AII-stimulated neutrophils of patients with hypercholesterolaemia (HCH). These oxidizing agents may be involved in the...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/s0898-6568(02)00017-7

    authors: Paragh G,Szabó J,Kovács E,Keresztes T,Kárpáti I,Balogh Z,Páll D,Fóris G

    更新日期:2002-09-01 00:00:00

  • CRISPR system: Discovery, development and off-target detection.

    abstract::As a revolutionary gene editing tool based on the adaptive immune defense mechanism of bacteria and archaea against exogenous DNA invasion, CRISPR/Cas system shows many remarkable characteristics over ZFNs and TALENs. However, off-target effect remains as one of the major imperfection of CRISPR/Cas system, hindering i...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2020.109577

    authors: Chen S,Yao Y,Zhang Y,Fan G

    更新日期:2020-06-01 00:00:00

  • Homer1 knockdown protects dopamine neurons through regulating calcium homeostasis in an in vitro model of Parkinson's disease.

    abstract::Homer1 protein is an important scaffold protein at postsynaptic density and has been demonstrated to play a central role in calcium signaling in the central nervous system. The aim of this study was to investigate the effects of Homer1 knockdown on MPP(+) induced neuronal injury in cultured dopamine (DA) neurons. We f...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2013.09.004

    authors: Chen T,Yang YF,Luo P,Liu W,Dai SH,Zheng XR,Fei Z,Jiang XF

    更新日期:2013-12-01 00:00:00

  • Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate].

    abstract::The ERBB1/2/4 inhibitor neratinib causes plasma membrane-associated K-RAS to mislocalize into intracellular vesicles; this effect is enhanced by HDAC inhibitors and the combination of [neratinib + sodium valproate] is now a phase I trial (NCT03919292). The present studies were performed to understand resistance mechan...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109525

    authors: Dent P,Booth L,Poklepovic A,Hoff DV,Hancock JF

    更新日期:2020-04-01 00:00:00

  • Inter- and intra-cellular mechanism of NF-kB-dependent survival advantage and clonal expansion of radio-resistant cancer cells.

    abstract::Understanding the underlying mechanism by which cancer cells acquire resistance to radiation and favorably selected for its clonal expansion will provide molecular insight into tumor recurrence at the treatment site. In the present study, we investigated the molecular mechanisms prompted in MCF-7 breast cancer cells i...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2017.01.011

    authors: Yu H,Aravindan N,Xu J,Natarajan M

    更新日期:2017-02-01 00:00:00

  • Positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis in budding yeast.

    abstract::The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anapha...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2016.07.005

    authors: Hatano Y,Naoki K,Suzuki A,Ushimaru T

    更新日期:2016-10-01 00:00:00

  • Function and evolution of ubiquitous bacterial signaling adapter phosphopeptide recognition domain FHA.

    abstract::Forkhead-associated domain (FHA) is a phosphopeptide recognition domain embedded in some regulatory proteins. With similar fold type to important eukaryotic signaling molecules such as Smad2 and IRF3, the role of bacterial FHA domain is intensively pursued. Reported bacterial FHA domain roles include: regulation of gl...

    journal_title:Cellular signalling

    pub_type: 杂志文章,评审

    doi:10.1016/j.cellsig.2012.11.019

    authors: Weiling H,Xiaowen Y,Chunmei L,Jianping X

    更新日期:2013-03-01 00:00:00

  • Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria.

    abstract::Zfra is a small size 31-amino-acid C2H2 zinc finger-like protein, which is known to interact with c-Jun N-terminal kinase 1 (JNK1), WW domain-containing oxidoreductase (WWOX, FOR or WOX1), TNF receptor-associated death domain protein (TRADD) and nuclear factor kappaB (NF-kappaB) during stress response. Here, we show t...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2008.02.018

    authors: Hsu LJ,Hong Q,Schultz L,Kuo E,Lin SR,Lee MH,Lin YS,Chang NS

    更新日期:2008-07-01 00:00:00

  • Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB.

    abstract::The TAK1 plays a pivotal role in the innate immune response of Drosophila by controlling the activation of JNK and NF-kappaB. Activation of TAK1 in mammals is mediated by two TAK1-binding proteins, TAB1 and TAB2, but the role of the TAB proteins in the immune response of Drosophila has not yet been established. Here, ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2005.08.020

    authors: Zhuang ZH,Sun L,Kong L,Hu JH,Yu MC,Reinach P,Zang JW,Ge BX

    更新日期:2006-07-01 00:00:00

  • ER stress signaling in ARPE-19 cells after inhibition of protein kinase CK2 by CX-4945.

    abstract::Protein kinase CK2 is a critical factor for the survival of cells. It is overexpressed in many cancer cells and provides protection against apoptosis in these cells. Inhibition of CK2 kinase activity in various cancer cells leads to apoptosis, which makes CK2 an attractive target for cancer therapy. Little is, however...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2014.03.014

    authors: Intemann J,Saidu NE,Schwind L,Montenarh M

    更新日期:2014-07-01 00:00:00

  • Adrenomedullin promotes cell cycle transit and up-regulates cyclin D1 protein level in human glioblastoma cells through the activation of c-Jun/JNK/AP-1 signal transduction pathway.

    abstract::Adrenomedullin is a secreted peptide hormone with multiple functions. Although a number of reports have indicated that adrenomedullin may be involved in tumor progression, its mechanism of action remains obscure. In this study, we have analysed the signal transduction pathway activated by adrenomedullin in human gliom...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2009.01.001

    authors: Ouafik L,Berenguer-Daize C,Berthois Y

    更新日期:2009-04-01 00:00:00

  • Both EGFR kinase and Src-related tyrosine kinases regulate human ether-à-go-go-related gene potassium channels.

    abstract::Human ether-à-go-go-related gene (hERG or Kv11.1) encodes the rapidly activated delayed rectifier K(+) current (I(Kr)) in the human heart. Potential regulation of hERG channel by protein tyrosine kinases (PTKs) is not understood. The present study was designed to investigate whether this channel is modulated by PTKs u...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2008.06.006

    authors: Zhang DY,Wang Y,Lau CP,Tse HF,Li GR

    更新日期:2008-10-01 00:00:00

  • Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.

    abstract::In this study, we demonstrate that EGF inhibits the TGF-β1-induced apoptosis of Huh7 cells. TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway. TGF-β1 also inhibits the activation of S6 kinase 1 which phosphorylates the serine 67 res...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2013.11.038

    authors: Matsuhashi S,Hamajima H,Xia J,Zhang H,Mizuta T,Anzai K,Ozaki I

    更新日期:2014-03-01 00:00:00

  • Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area.

    abstract::Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins, and that the Ser 824 residue of TRPV4 is phosphorylated by SGK1. In this study, ...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2011.11.002

    authors: Shin SH,Lee EJ,Hyun S,Chun J,Kim Y,Kang SS

    更新日期:2012-03-01 00:00:00

  • T cell tyrosine phosphorylation response to transient redox stress.

    abstract::Reactive Oxygen Species (ROS) are crucial to multiple biological processes involved in the pathophysiology of inflammation, and are also involved in redox signaling responses. Although previous reports have described an association between oxidative events and the modulation of innate immunity, a role for redox signal...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2014.12.014

    authors: Secchi C,Carta M,Crescio C,Spano A,Arras M,Caocci G,Galimi F,La Nasa G,Pippia P,Turrini F,Pantaleo A

    更新日期:2015-04-01 00:00:00

  • FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1.

    abstract::Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinic...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2020.109665

    authors: Fan GH,Zhu TY,Huang J

    更新日期:2020-08-01 00:00:00

  • Transforming growth factor-β stimulates human ovarian cancer cell migration by up-regulating connexin43 expression via Smad2/3 signaling.

    abstract::Reduced connexin43 (Cx43) expression is frequently detected in different types of human cancer. Cx43 has been shown to regulate cancer cell migration in a cell-type dependent manner. In both primary and recurrent human ovarian cancer, overexpression of TGF-β ligand and its receptors have been detected. TGF-β can regul...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2015.07.010

    authors: Qiu X,Cheng JC,Zhao J,Chang HM,Leung PC

    更新日期:2015-10-01 00:00:00

  • Nore1B regulates TCR signaling via Ras and Carma1.

    abstract::Nore1A was originally identified as a potential Ras effector, and Nore1B is an alternatively spliced isoform. Both share a Ras/Rap association domain (RA domain) but only Nore1A contains sequence motifs that predict SH3 domain binding and diacylglycerol/phorbol ester binding in the amino-terminal region. Here we repor...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2006.01.015

    authors: Ishiguro K,Avruch J,Landry A,Qin S,Ando T,Goto H,Xavier R

    更新日期:2006-10-01 00:00:00

  • Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.

    abstract::Timeless was originally identified in Drosophila as an essential component of circadian cycle regulation, where its function is tightly controlled at the protein level by tyrosine phosphorylation and subsequent degradation. In mammals, Timeless has also been implicated in circadian rhythms as well as cell cycle contro...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2012.12.009

    authors: O'Reilly LP,Zhang X,Smithgall TE

    更新日期:2013-04-01 00:00:00

  • Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A.

    abstract::Recent studies have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in cancer development and progression. However, the mechanism by which lncRNAs contribute to colorectal cancer remains unclear. In this study, we identified the lncRNA, DANCR, which was upregulated in colorectal cancer. The upregu...

    journal_title:Cellular signalling

    pub_type: 杂志文章

    doi:10.1016/j.cellsig.2019.109502

    authors: Lian J,Zhang H,Wei F,Li Q,Lu Y,Yu B,Yu L,Liang X,Wen Y,Jin K,Tang J,Xie W

    更新日期:2020-03-01 00:00:00