Abstract:
BACKGROUND:Severe obesity and metabolic syndrome have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). We evaluated the diagnostic value of liver stiffness measurement (LSM), by transient elastography (FibroScan®) in bariatric surgery candidates with suspected NAFLD. METHODS:A total of 100 prospectively included consecutive severely obese subjects underwent bariatric surgery with liver needle biopsy. LSM was performed in the 15 days preceding liver biopsy. RESULTS:According to Kleiner's classification, 28 patients had no fibrosis, 50 had stage F1 fibrosis, 13 had stage F2 fibrosis, and nine had stage F3 fibrosis. LSMs were higher in patients with fibrosis stage F ≥2, than in patients with a fibrosis stage below F2 (p < 0.001). Fibrosis stage (p < 0.002), amount of steatosis (%) (p < 0.001), BMI (p < 0.02), and activity score (p = 0.027) were independently correlated with LSM. Homeostasis model assessment (HOMA) index was also significantly and independently correlated with LSM (p < 0.01). The area under the receiver operating characteristic curve (AUROC) generated by FibroScan® was 0.81 ± 0.05 for predicting fibrosis stage F ≥2 and 0.85 ± 0.04 for predicting F3 fibrosis. The decrease in LSM 1 year after bariatric surgery was significantly correlated with changes in HOMA index (r = 0.43, p = 0.01), but not with changes in BMI or weight. CONCLUSION:FibroScan® allows the early diagnosis of fibrosis in severely obese patients. Our results also suggest that FibroScan® could identify a subgroup of NAFLD patients at high risk of progressive liver disease and that LSM could be used as a surrogate marker of insulin resistance. Further studies are required to evaluate the prognostic value of FibroScan®.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Naveau S,Lamouri K,Pourcher G,Njiké-Nakseu M,Ferretti S,Courie R,Tranchart H,Ghinoiu M,Balian A,Prévot S,Perlemuter G,Dagher Idoi
10.1007/s11695-014-1235-9subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1693-701issue
10eissn
0960-8923issn
1708-0428journal_volume
24pub_type
临床试验,杂志文章相关文献
OBESITY SURGERY文献大全abstract:BACKGROUND:Type 1 diabetes mellitus (T1DM) has a rising global prevalence. Although it is vastly outnumbered by type 2 diabetes mellitus rates, it remains a persistent worldwide source of morbidity and mortality. Increasingly, its sufferers are afflicted by obesity and its complications. The objective of the study is t...
journal_title:Obesity surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11695-015-1999-6
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Biliopancreatic diversion (BPD) is the most effective bariatric procedure. Around 70% of these patients have secondary hyperparathyroidism (SH) in the long term as a consequence of calcium and vitamin D malabsorption. This work was aimed to study the influence of SH on bone turnover and its relationship with...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-009-0028-z
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Impairment in health-related quality of life (HRQOL) is described as a major concern for severely obese adolescents seeking intentional weight loss. We aimed to compare HRQOL in obese adolescents seeking weight loss with body mass index (BMI)-matched younger adults and community norms. METHODS:Eighty-one ad...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-015-1677-8
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Despite their current limitations, metabolic surgery and natural orifice transluminal endoscopic surgery (NOTES), set new horizons. In this article, the first three cases of adjustable gastric banding (AGB) through transvaginal access in obese women are described. METHODS:In the General and Vascular Surgery...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-010-0130-2
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Bile acids have been implicated in the mechanism by which Roux-en-Y gastric bypass (RYGB) can induce remission of type 2 diabetes (T2D). Our goal was to identify circulating proteins whose levels changed after RYGB when dysglycemic parameters normalized. MATERIALS AND METHODS:This was a retrospective study ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-04993-4
更新日期:2020-09-28 00:00:00
abstract:PURPOSE:The number of laparoscopic adjustable gastric banding (LAGB) removal has increased throughout the years. The aim of the study was to evaluate the outcomes in patients undergoing LAGB removal with or without further bariatric surgery. MATERIALS AND METHODS:Data prospectively collected from consecutive patients ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3373-y
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The staple line leakage is a dangerous complication of sleeve gastrectomy. Various strategies have been tried to reduce the leakage risk. The amniotic membrane (AmM) is the inner layer of the placental membranes and has anti-inflammatory, anti-fibrosis, and anti-scarring effects, and it also has lower immune...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-04027-8
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Despite reported effectiveness, weight loss surgery (WLS) still remains one of the least preferred options for outpatient providers, especially in Germany. The aim of this study was to examine the effect of stigma and knowledge on recommendation of WLS and referral to a surgeon by general practitioners (GPs)...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2104-5
更新日期:2016-10-01 00:00:00
abstract::Roux-Y gastric bypass with transection in an anterio-posterior oblique fashion and an 11-12 mm internal diameter gastrojejunostomy supported by an external strip of linea alba fascia is safe and effective as a primary or revision procedure, with a very low failure and revision rate. ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089291765561051
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Duodenal-jejunal bypass (DJB) surgery can induce rapid and durable remission of type 2 diabetes mellitus (T2DM), but the intrinsic mechanisms remain to be elucidated. Recent studies indicated that improved hepatic insulin resistance and insulin signaling transduction might contribute to the diabetic control ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-014-1308-9
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Laparoscopic adjustable gastric banding (LAGB) is a proven method for weight reduction. Less is known about pregnancies in patients after LAGB. METHODS:Information was gathered, through database and survey, on women who underwent LAGB at NYU Medical Center between 2001 and 2008 then became pregnant. RESULT...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-010-0265-1
更新日期:2011-10-01 00:00:00
abstract::The female population represents three-fourths of patients undergoing a bariatric procedure and could be scheduled for surgery in their postpartum period. We report a difficult case of a female patient who underwent a laparoscopic sleeve gastrectomy 6 weeks postpartum. The postpartum period is accompanied by pronounce...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2154-8
更新日期:2016-06-01 00:00:00
abstract::In an attempt to improve the results of biliopancreatic diversion in the treatment of morbid obesity, two aspects of the procedure performed at Laval Hospital were modified to reduce adverse physiological consequences. The distal gastrectomy was replaced by a parietal gastrectomy which preserves vagal continuity along...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089293765559728
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:We tested the hypothesis that the amount of weight lost after Roux-en-Y gastric bypass (RYGBP) correlates with plasma ghrelin levels. METHODS:36 morbidly obese patients were studied 3 years after RYGBP (6 men, 30 women) with mean initial BMI 51 kg/m2 and 8 healthy controls (2 men, 6 women) with mean BMI 25 ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/0960892054621071
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Partially covered self-expandable metallic stents (PCSEMS), although an effective treatment for anastomotic/staple line leaks and strictures, can be difficult to remove. This study examines the effectiveness of the inversion technique for the removal of PCSEMS in the treatment of leaks and stricture...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-2811-6
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Despite recognition of the importance of laparoscopic adjustable gastric banding (LAGB) aftercare for optimal surgical outcomes and the failure of some patients to attend regularly, factors influencing LAGB aftercare attrition have not been thoroughly examined in the literature. METHODS:Patients' perspectiv...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-013-1086-9
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Revisional surgery has become a widely accepted alternative for weight loss failure/regain after bariatric surgery. However, it is associated to higher morbi-mortality and lesser weight loss than primary bariatric procedure. Our aims are to present a novel technique for weight loss treatment after failed lap...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-014-1463-z
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:It is unclear whether specific gut microbiota is associated with remission of type 2 diabetes (T2D) after distinct types of bariatric surgery. AIMS:The aim of this study is to examine gut microbiota changes after laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery in obese patien...
journal_title:Obesity surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11695-016-2399-2
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed procedures for surgical weight loss. It has been shown that overweight may be associated with an increased risk of gastric cancer. However, the risk of remnant gastric cancer after RYGB has not been defined yet and the development of n...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-019-03892-7
更新日期:2019-08-01 00:00:00
abstract::Lithium is one of the major treatment options in bipolar disorder. Bariatric surgery can significantly modify the oral bioavailability of drugs, and lithium is no exception; although in most cases drug absorption seems to decrease, in the case of lithium, toxicity is the risk. In this article, we describe a 61-year-ol...
journal_title:Obesity surgery
pub_type: 杂志文章,评审
doi:10.1007/s11695-018-3597-x
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Sleeve gastrectomy (SG) is the most common bariatric procedure performed worldwide. However, without a standardised surgical technique, heterogeneous outcomes and complications such as gastro-oesophageal reflux disease (GERD) have been reported. The aim of this study was to identify reproducible anatomical c...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-020-05156-1
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:Laparoscopic adjustable gastric banding (LAGB) has gained widespread acceptance. However, the technique has problems intrinsic to the material wear and tear around the port and connecting tubing that can lead to failure. Port complications are considered to be minor; however, few studies have analyzed them, ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/0960892053576604
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Certain risk factors for arteriosclerosis are associated with obesity, e.g. hypertension, insulin resistance, the high triglyceride - low HDL pattern. One aim in treating morbid obesity is to reduce these risk factors. This study was designed to follow metabolic risk factors after weight loss in 165 morbidly...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089298765554980
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:The Beck Depression Inventory (BDI) is commonly used in the screening and evaluation process with bariatric surgery candidates despite relatively limited psychometric evidence in this patient group. We examined the validity of the BDI and its clinical utility for subtyping women seeking gastric bypass surger...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-016-2047-x
更新日期:2016-09-01 00:00:00
abstract::The success of vertical banded gastroplasty (VBG) in the obese transplanted population is measured by a low operative morbidity and mortality in the context of a good record of permanent weight loss and an enhanced quality of life. Selection of transplanted patients for gastroplasty should be guided by the prevailing ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1381/096089291765560890
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Weight loss following bariatric surgery can improve cardiac function among patients with heart failure (HF). However, perioperative morbidity of bariatric surgery has not been evaluated in patients with HF. STUDY DESIGN:The National Surgical Quality Improvement Project (NSQIP) database for 2006-2014 was que...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-018-3174-3
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Gamma-glutamyltranspeptidase (GGT) levels are an independent risk marker for the development of type 2 diabetes (T2DM). We investigated the relationship between the newly identified serum GGT fractions and glucose metabolism in obese subjects before and after bariatric surgery. SUBJECTS/METHODS:T...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-017-3017-7
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Obese patients have a propensity to desaturate during induction of general anesthesia secondary to their reduced functional residual capacity and increased oxygen consumption. Apneic oxygenation can provide supplemental oxygen to the alveoli, even in the absence of ventilation, during attempts to secure the ...
journal_title:Obesity surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11695-019-04077-y
更新日期:2019-12-01 00:00:00
abstract::Severe hypocalcemia complicating cervical endocrine surgery in patients with gastric bypass can constitute a major concern. When usual therapies fail to maintain calcemia within the normal range without secondary adverse events, reversal of the bariatric surgery should be considered. We herein report the outcomes of l...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-019-04132-8
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Sleeve gastrectomy is a bariatric surgical procedure that may result in particular morbidity or mortality due to gastric fistula in the proximal part of the gastric tube. Two theories are currently proposed to explain this specific leak location. The vascular theory attributes the leaks to reduced perfusion ...
journal_title:Obesity surgery
pub_type: 杂志文章
doi:10.1007/s11695-014-1256-4
更新日期:2014-10-01 00:00:00