The use of ferrokinetics in the study of experimental anemia.

Abstract:

:Erythropoietic cells in bone marrow are vulnerable to cytotoxic substances. There are three types of erythroid precursors: cells that can take up Fe but do not proliferate (reticulocytes), those that can take up Fe and proliferate (normoblasts and pronormoblasts), and those cells that do not take up Fe but can proliferate and differentiate into the erythroid cell line (ERC and stem cells). Each of these erythroid precursors requires a certain time before they emerge into the peripheral blood as mature red blood cells. By applying our understanding of ferrokinetics associated with erythropoiesis, it was possible to estimate a cytotoxic effect of chemicals on proliferating erythgroid precursors (pronormoblasts) in mice by measuring 24-hr 59Fe uptake in red blood cells 48 hr after treatment with chemicals. The effect of chemicals on pluripotent hemopoietic stem cells in mice was also estimated by measuring 24-hr 59Fe uptake 72 hr after treatment with chemicals. The validity of experimental schemes was tested using cytarabine, methotrexate, vinblastine, cyclophosphamide, and busulfan, which are known to act against specific cell types. Effects on pluripotent hemopoietic stem cells were tested with or without activation of stem cells in G0 into cell cycle. Applications of the 59Fe uptake method in the study of (1) benzene toxicity and (2) effect of pentobarbital on the toxic action of hydroxyurea and cytarabine are described. Proper application of the ferrokinetic characteristics of erythropoietic cells enables the establishment of a methodology which can be used to evaluate potential toxic effects of chemicals on erythroid precursor cells and pluripotent hemopoietic stem cells.

authors

Lee EW,Kocsis JJ,Snyder R

doi

10.1289/ehp.813929

subject

Has Abstract

pub_date

1981-06-01 00:00:00

pages

29-37

eissn

0091-6765

issn

1552-9924

journal_volume

39

pub_type

杂志文章,评审
  • Role of biopersistence in the pathogenicity of man-made fibers and methods for evaluating biopersistence: a summary of two round-table discussions.

    abstract::This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman)...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.94102s5277

    authors: McClellan RO,Hesterberg TW

    更新日期:1994-10-01 00:00:00

  • Neurogenic inflammation and sensitivity to environmental chemicals.

    abstract::Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.93101234

    authors: Meggs WJ

    更新日期:1993-08-01 00:00:00

  • Unfair trade: e-waste in Africa.

    abstract::Africa is quickly becoming a destination for information technology in the form of tons of used computers, fax machines, cell phones, and other electronics. Although many of these machines can be repaired and resold, up to 75% of the electronics shipped to Africa is junk. This equipment, when dumped, may leach lead, m...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.114-a232

    authors: Schmidt CW

    更新日期:2006-04-01 00:00:00

  • Analysis of dietary intake of selected metals in the NHEXAS-Maryland investigation.

    abstract::As part of a large pilot investigation of multimedia exposure to several classes of environmental contaminants, the National Human Exposure Assessment Survey (NHEXAS)-Maryland study, we collected 388 semiquantitative food checklists and duplicate diet solid food samples, analyzed for arsenic, cadmium, chromium, and le...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109121

    authors: Ryan PB,Scanlon KA,MacIntosh DL

    更新日期:2001-02-01 00:00:00

  • Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study.

    abstract:BACKGROUND:Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. OBJECTIVE:We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutant...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1308016

    authors: Robledo CA,Yeung E,Mendola P,Sundaram R,Maisog J,Sweeney AM,Barr DB,Louis GM

    更新日期:2015-01-01 00:00:00

  • Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta.

    abstract:BACKGROUND:Pregnancy is a sensitive condition during which adverse environmental exposures should be monitored thoroughly and minimized whenever possible. In particular, the hormone balance during gestation is delicate, and disturbance may cause acute or chronic long-term health effects. A potential endocrine disruptio...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP4860

    authors: Warth B,Preindl K,Manser P,Wick P,Marko D,Buerki-Thurnherr T

    更新日期:2019-10-01 00:00:00

  • Epidemiologic studies of environmental agents and systemic autoimmune diseases.

    abstract::Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.99107s5743

    authors: Mayes MD

    更新日期:1999-10-01 00:00:00

  • Benzene and leukemia: an epidemiologic risk assessment.

    abstract::To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8982189

    authors: Rinsky RA

    更新日期:1989-07-01 00:00:00

  • Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy.

    abstract::Basophilic hepatic foci, nodules, and trabecular hepatocellular carcinomas, collectively referred to as focal hepatic lesions, were induced by single injections of 5.0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice. Groups of eight experimental and eigh...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8350149

    authors: Goldfarb S,Pugh TD,Koen H,He YZ

    更新日期:1983-04-01 00:00:00

  • Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols.

    abstract:BACKGROUND:In an effort to decrease the rates of smoking conventional tobacco cigarettes, electronic cigarettes (e-cigarettes) have been proposed as an effective smoking cessation tool. However, little is known about their toxicological impacts. This is concerning given that e-cigarette use is perceived as less harmful...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP6067

    authors: Church JS,Chace-Donahue F,Blum JL,Ratner JR,Zelikoff JT,Schwartzer JJ

    更新日期:2020-04-01 00:00:00

  • Polychlorinated dibenzo-p-dioxins and dibenzofurans in fly ash and cinders collected from several municipal incinerators in Japan.

    abstract::Determination of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in fly ash and cinders collected from nine municipal incinerators in Japan was made. The concentrations of PCDDs and PCDFs in this study were generally in the same range as those in Europe and North America. However, t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.59-1568091

    authors: Wakimoto T,Tatsukawa R

    更新日期:1985-02-01 00:00:00

  • Chernobyl fallout and outcome of pregnancy in Finland.

    abstract::Possible effects of Chernobyl fallout on outcome of pregnancy in Finland were evaluated in a nationwide follow-up study. The outcomes were the rate of live births and stillbirths, pregnancy loss, and induced abortions by municipality. Exposure was assessed based on nationwide surveys of radiation dose rate from the Ch...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109179

    authors: Auvinen A,Vahteristo M,Arvela H,Suomela M,Rahola T,Hakama M,Rytömaa T

    更新日期:2001-02-01 00:00:00

  • Metabolism of 2-aminofluorene by human polymorphonuclear leukocytes: more evidence for the association between inflammation and cancer.

    abstract::Recent investigations have demonstrated the ability of leukocytes to metabolize promutagens or procarcinogens into their genotoxic forms. As a possible explanation for the association between inflammation and cancer, we and others have hypothesized that local accumulations of leukocytes could take up nearby promutagen...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s327

    authors: Isola VJ,Hartman TC,Trumble SJ,Ruzek MC,Gentile JM

    更新日期:1993-10-01 00:00:00

  • Cardiovascular actions of palladium compounds in the unanesthetized rat.

    abstract::The natural occurrence of palladium (Pd) is rare. It is obtained as a by-product during the extraction of platinum and, until the present time, its uses were small in number--principally in the manufacture of jewelry, dental alloys, chemical catalysts, and electrical contacts. Interest in Pd toxicology has been limite...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.751241

    authors: Wiester MJ

    更新日期:1975-12-01 00:00:00

  • Benzene: epidemiologic observations of leukemia by cell type and adverse health effects associated with low-level exposure.

    abstract::Benzene has been known to be a bone marrow poison for almost a century. However, it was not until the last decade that benzene's carcinogenic potential was demonstrated by epidemiologic studies. The proposed regulation by the Occupational Safety and Health Administration (OSHA) to lower exposure levels of benzene in t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.835275

    authors: Infante PF,White MC

    更新日期:1983-10-01 00:00:00

  • Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit.

    abstract::The subchronic inhalation toxicology of ethylene glycol monoethyl ether (EGEE) was evaluated in rats and rabbits using a 13-week exposure regimen. Groups of 20 rabbits (10 M, 10 F) and 30 rats (15 M, 15 F) were exposed to a vapor of 25 ppm, 100 ppm, or 400 ppm, 6 hr/day, 5 days/week. The control groups received air on...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8457157

    authors: Barbee SJ,Terrill JB,DeSousa DJ,Conaway CC

    更新日期:1984-08-01 00:00:00

  • Evaluation criteria for publishing in top-tier journals in environmental health sciences and toxicology.

    abstract:BACKGROUND:Trying to publish a paper in a top-rated peer-reviewed journal can be a difficult and frustrating experience for authors. It is important that authors understand the general review process before submitting manuscripts for publication. OBJECTIVES:Editors-in-chief and associate editors from top-tier journals...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1003280

    authors: Lee BM

    更新日期:2011-07-01 00:00:00

  • Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice.

    abstract:BACKGROUND:The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothe...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP1937

    authors: Chappell GA,Israel JW,Simon JM,Pott S,Safi A,Eklund K,Sexton KG,Bodnar W,Lieb JD,Crawford GE,Rusyn I,Furey TS

    更新日期:2017-10-16 00:00:00

  • Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography.

    abstract::Most of the composites and sealants used in dentistry are based on bisphenol A diglycidylether methacrylate (Bis-GMA). Reports revealed that in situ polymerization is not complete and that free monomers can be detected by different analytic methods. Concerns about the estrogenicity of bisphenol A (BPA) and other aroma...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0010821

    authors: Pulgar R,Olea-Serrano MF,Novillo-Fertrell A,Rivas A,Pazos P,Pedraza V,Navajas JM,Olea N

    更新日期:2000-01-01 00:00:00

  • Cytotoxic action of mineral dusts on CHV 79 cells in vitro: factors affecting toxicity.

    abstract::The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8351189

    authors: Lock SO,Chamberlain M

    更新日期:1983-09-01 00:00:00

  • Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies.

    abstract:BACKGROUND:Ocean pollution affects marine organisms and ecosystems as well as humans. The International Oceanographic Commission recommends ocean health monitoring programs to investigate the presence of marine contaminants and the health of threatened species and the use of multiple and early-warning biomarker approac...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0901809

    authors: Godard-Codding CA,Clark R,Fossi MC,Marsili L,Maltese S,West AG,Valenzuela L,Rowntree V,Polyak I,Cannon JC,Pinkerton K,Rubio-Cisneros N,Mesnick SL,Cox SB,Kerr I,Payne R,Stegeman JJ

    更新日期:2011-03-01 00:00:00

  • Asbestos-induced peritoneal mesothelioma in a construction worker.

    abstract::Occupational and environmental asbestos exposure continues to represent a public health problem, despite increasingly restrictive laws adopted by most industrialized countries. Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6542

    authors: Fonte R,Gambettino S,Melazzini M,Scelsi M,Zanon C,Candura SM

    更新日期:2004-04-01 00:00:00

  • Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa).

    abstract:BACKGROUND:The etiologies of the male urogenital anomalies hypospadias and cryptorchidism remain unclear. It has been suggested that maternal diet and environmental contaminants may affect the risk of these anomalies via placental or hormonal disturbances. OBJECTIVES:We examined associations between organic food consu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409518

    authors: Brantsæter AL,Torjusen H,Meltzer HM,Papadopoulou E,Hoppin JA,Alexander J,Lieblein G,Roos G,Holten JM,Swartz J,Haugen M

    更新日期:2016-03-01 00:00:00

  • Household air pollution from coal and biomass fuels in China: measurements, health impacts, and interventions.

    abstract:OBJECTIVE:Nearly all China's rural residents and a shrinking fraction of urban residents use solid fuels (biomass and coal) for household cooking and/or heating. Consequently, global meta-analyses of epidemiologic studies indicate that indoor air pollution from solid fuel use in China is responsible for approximately 4...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9479

    authors: Zhang JJ,Smith KR

    更新日期:2007-06-01 00:00:00

  • Urinary Phthalate Metabolite Concentrations and Breast Cancer Incidence and Survival following Breast Cancer: The Long Island Breast Cancer Study Project.

    abstract:BACKGROUND:Phthalates, known endocrine disruptors, may play a role in breast carcinogenesis. Few studies have examined phthalates in relation to breast cancer (BC), and, to our knowledge, none have considered survival following BC. OBJECTIVES:We examined 11 urinary phthalate metabolites, individually and as molar sum ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP2083

    authors: Parada H Jr,Gammon MD,Chen J,Calafat AM,Neugut AI,Santella RM,Wolff MS,Teitelbaum SL

    更新日期:2018-04-26 00:00:00

  • Relevance of animal experiments to humans.

    abstract::The best evidence of an adverse human health effect is a properly conducted epidemiological study. But human beings should not be the sole test animal. Properly conducted animal studies have been shown to be preductive for carcinogenicity and toxicologic responses in human populations. We need to develop more efficien...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7932297

    authors: Rall DP

    更新日期:1979-10-01 00:00:00

  • A framework for assessing risks to children from exposure to environmental agents.

    abstract::In recent years there has been an increasing focus in environmental risk assessment on children as a potentially susceptible population. There also has been growing recognition of the need for a systematic approach for organizing, evaluating, and incorporating the available data on children's susceptibilities in risk ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.6182

    authors: Daston G,Faustman E,Ginsberg G,Fenner-Crisp P,Olin S,Sonawane B,Bruckner J,Breslin W,McLaughlin TJ

    更新日期:2004-02-01 00:00:00

  • Expanded operational concept of high risk groups and its role in standard setting.

    abstract::The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8352257

    authors: Calabrese EJ

    更新日期:1983-10-01 00:00:00

  • Chlorpyrifos accumulation patterns for child-accessible surfaces and objects and urinary metabolite excretion by children for 2 weeks after crack-and-crevice application.

    abstract::The Children's Post-Pesticide Application Exposure Study (CPPAES) was conducted to look at the distribution of chlorpyrifos within a home environment for 2 weeks after a routine professional crack-and-crevice application and to determine the amount of the chlorpyrifos that is absorbed by a child living within the home...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6984

    authors: Hore P,Robson M,Freeman N,Zhang J,Wartenberg D,Ozkaynak H,Tulve N,Sheldon L,Needham L,Barr D,Lioy PJ

    更新日期:2005-02-01 00:00:00

  • Enablers and barriers to large-scale uptake of improved solid fuel stoves: a systematic review.

    abstract:BACKGROUND:Globally, 2.8 billion people rely on household solid fuels. Reducing the resulting adverse health, environmental, and development consequences will involve transitioning through a mix of clean fuels and improved solid fuel stoves (IS) of demonstrable effectiveness. To date, achieving uptake of IS has present...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.1306639

    authors: Rehfuess EA,Puzzolo E,Stanistreet D,Pope D,Bruce NG

    更新日期:2014-02-01 00:00:00