Reduced hydrolytic lability of epoprostenol in the presence of cationic micelles.

Abstract:

:The rapid hydrolysis of epoprostenol to 6-keto-prostaglandin F1 alpha is hydronium ion-catalyzed even at pH 10 or higher. In the presence of 1.0% hexadecyltrimethylammonium chloride, the rate was reduced significantly (1580-fold at pH 2 and 283-fold at a physiological pH). This decrease in the hydrolysis rate is attributed to two causes: favorable partitioning of epoprostenol in the micellar phase and electrostatic repulsion between the hydronium ion and the cationic micellar surface.

journal_name

J Pharm Sci

authors

Cho MJ

doi

10.1002/jps.2600710420

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

453-4

issue

4

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)44129-2

journal_volume

71

pub_type

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