Abstract:
PURPOSE:The purpose of this study was to determine the effects of early outpatient exercise on muscle mass, function, and fractional synthetic rate in severely burned children. METHODS:Forty-seven children with ≥40% total body surface area burn performed a 12-wk standard of care rehabilitation (SOC, n = 23) or rehabilitative exercise training (RET, n = 24) immediately after hospital discharge. Dual-energy x-ray absorptiometry was used to assess lean body mass (LBM) at discharge, posttreatment, and 12 months post-burn. Muscle function was evaluated with a Biodex Isokinetic Dynamometer, and peak aerobic fitness (V˙O2peak) was measured using a modified Bruce treadmill protocol posttreatment. Stable isotope infusion studies were performed in a subset of patients (SOC, n = 13; RET, n = 11) at discharge and posttreatment to determine mixed-muscle fractional synthetic rate. RESULTS:Relative peak torque (RET, 138 ± 9 N·m·kg, vs SOC, 106 ± 9 N·m·kg) and V˙O2peak (RET, 32 ± 1 mL·kg·min, vs SOC, 28 ± 1 mL·kg·min) were greater at posttreatment with RET compared with those with SOC. In addition, RET increased whole-body (9% ± 2%) and leg (17% ± 3%) LBM compared with SOC. Furthermore, the percentage change in whole-body (18% ± 3%) and leg (31% ± 4%) LBM from discharge to 12 months post-burn was greater with RET compared to SOC. Muscle fractional synthetic rate decreased from discharge to posttreatment in both groups (6.9% ± 1.1% per day vs 3.4 ± 0.4% per day); however, no differences were observed between treatment groups at each time point. CONCLUSIONS:Early outpatient exercise training implemented at hospital discharge represents an effective intervention to improve muscle mass and function after severe burn injury.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Hardee JP,Porter C,Sidossis LS,Børsheim E,Carson JA,Herndon DN,Suman OEdoi
10.1249/MSS.0000000000000296subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1710-6issue
9eissn
0195-9131issn
1530-0315journal_volume
46pub_type
杂志文章,随机对照试验abstract:PURPOSE:This is a case study of an aerobically trained, multisport, female athlete (age = 39) diagnosed with stage IIIc human epidermal growth factor receptor 2 positive breast cancer. The focus of the study is on measures of cardiorespiratory fitness (V˙O2peak) through the course of cancer therapy. METHODS:A symptom-...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000987
更新日期:2016-10-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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pub_type: 杂志文章,meta分析,评审
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journal_title:Medicine and science in sports and exercise
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更新日期:1988-06-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
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更新日期:1993-05-01 00:00:00
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更新日期:2004-09-01 00:00:00
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更新日期:2014-03-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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更新日期:2016-03-01 00:00:00
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