On the use of ibotenic acid to lesion selectively different components of the hippocampal formation.

Abstract:

:Procedures are described for lesioning two components of the hippocampal formation (hippocampus, subiculum) using multiple injections of small amounts of ibotenic acid (IBO). The resulting loss of cells is more selective and limited than can be obtained with conventional techniques. Thus, problems associated with damage to adjacent areas, fibers-of-passage, and damage to the vasculature are minimized. The results of behavioral experiments indicate that the effects of IBO lesions of the hippocampus are more subtle than those found with conventional lesion techniques. The general approach of using multiple injections of small amounts of neurotoxins can be used to selectively lesion other components of the hippocampal formation.

journal_name

J Neurosci Methods

authors

Jarrard LE

doi

10.1016/0165-0270(89)90149-0

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

251-9

issue

3

eissn

0165-0270

issn

1872-678X

pii

0165-0270(89)90149-0

journal_volume

29

pub_type

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