Electronic cigarettes and nicotine clinical pharmacology.

Abstract:

OBJECTIVE:To review the available literature evaluating electronic cigarette (e-cigarette) nicotine clinical pharmacology in order to understand the potential impact of e-cigarettes on individual users, nicotine dependence and public health. METHODS:Literature searches were conducted between 1 October 2012 and 30 September 2013 using key terms in five electronic databases. Studies were included in the review if they were in English and publicly available; non-clinical studies, conference abstracts and studies exclusively measuring nicotine content in e-cigarette cartridges were excluded from the review. RESULTS:Nicotine yields from automated smoking machines suggest that e-cigarettes deliver less nicotine per puff than traditional cigarettes, and clinical studies indicate that e-cigarettes deliver only modest nicotine concentrations to the inexperienced e-cigarette user. However, current e-cigarette smokers are able to achieve systemic nicotine and/or cotinine concentrations similar to those produced from traditional cigarettes. Therefore, user experience is critically important for nicotine exposure, and may contribute to the products' ability to support and maintain nicotine dependence. CONCLUSIONS:Knowledge about e-cigarette nicotine pharmacology remains limited. Because a user's e-cigarette experience may significantly impact nicotine delivery, future nicotine pharmacokinetic and pharmacodynamic studies should be conducted in experienced users to accurately assess the products' impact on public health.

journal_name

Tob Control

journal_title

Tobacco control

authors

Schroeder MJ,Hoffman AC

doi

10.1136/tobaccocontrol-2013-051469

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

ii30-5

eissn

0964-4563

issn

1468-3318

pii

tobaccocontrol-2013-051469

journal_volume

23 Suppl 2

pub_type

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