Abstract:
OBJECTIVES:Advanced imaging studies have demonstrated that urate deposition in periarticular structures, such as tendons, is common in gout. The aim of this study was to investigate the effects of monosodium urate monohydrate (MSU) crystals on tenocyte viability and function. METHODS:The histological appearance of tendons in joints affected by advanced gout was examined using light microscopy. In vitro, colorimetric assays and flow cytometry were used to assess cell viability in primary rat and primary human tenocytes cultured with MSU crystals. Real-time PCR was used to determine changes in the relative mRNA expression levels of tendon-related genes, and Sirius red staining was used to measure changes in collagen deposition in primary rat tenocytes. RESULTS:In joint samples from patients with gout, MSU crystals were identified within the tendon, adjacent to and invading into tendon, and at the enthesis. MSU crystals reduced tenocyte viability in a dose-dependent manner. MSU crystals decreased the mRNA expression of tendon collagens, matrix proteins and degradative enzymes and reduced collagen protein deposition by tenocytes. CONCLUSIONS:These data indicate that MSU crystals directly interact with tenocytes to reduce cell viability and function. These interactions may contribute to tendon damage in people with advanced gout.
journal_name
Ann Rheum Disjournal_title
Annals of the rheumatic diseasesauthors
Chhana A,Callon KE,Dray M,Pool B,Naot D,Gamble GD,Coleman B,McCarthy G,McQueen FM,Cornish J,Dalbeth Ndoi
10.1136/annrheumdis-2013-204657subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1737-41issue
9eissn
0003-4967issn
1468-2060pii
annrheumdis-2013-204657journal_volume
73pub_type
杂志文章abstract:OBJECTIVES:To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS:A web-based exercise and subsequent patien...
journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
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doi:10.1136/ard.48.7.539
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pub_type: 杂志文章
doi:10.1136/ard.40.3.245
更新日期:1981-06-01 00:00:00
abstract::We describe a patient with rheumatoid arthritis and widespread joint and periarticular calcinosis related to self-medication with vitamin D, which was aggravated by oral phosphate therapy prescribed for her hypercalcaemia. Hydroxyapatite was shown in the synovial fluid from affected joints. The role played by tissue i...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.47.7.542
更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2008.089243
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.37.3.266
更新日期:1978-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.50.12.917
更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.51.12.1296
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pub_type: 杂志文章
doi:10.1136/ard.45.1.75
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pub_type: 杂志文章
doi:10.1136/ard.34.3.219
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journal_title:Annals of the rheumatic diseases
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/annrheumdis-2011-200941
更新日期:2012-11-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 临床试验,杂志文章,评审
doi:10.1136/ard.44.2.134
更新日期:1985-02-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2010.144774
更新日期:2011-09-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.34.1.92
更新日期:1975-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 临床试验,杂志文章
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更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...
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更新日期:2020-10-13 00:00:00
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pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00