Determination of pindolol in biological fluids by electron-capture GLC.

Abstract:

:An electron-capture GLC method was developed for measuring pindolol in human plasma and urine. The unchanged drug was extracted with benzene from alkalinized plasma or urine using propranolol as the internal standard. Both compounds subsequently were back-extracted into 0.1 M HCl and then into benzene. After evaporation of the organic phase, the compounds were derivatized with trifluoroacetylimidazole to form the trifluoroacetyl ester of pindolol and propranolol. These derivatives then were analyzed by electron-capture GLC. The method allowed the measurement of concentrations as low as 1 ng of pindolol/ml of plasma and was applied successfully to determinations of plasma levels in humans after oral administraton of a single 10-mg dose of pindolol.

journal_name

J Pharm Sci

authors

Guerret M,Lavene D,Kiechel JR

doi

10.1002/jps.2600691019

subject

Has Abstract

pub_date

1980-10-01 00:00:00

pages

1191-3

issue

10

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)43401-X

journal_volume

69

pub_type

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