Abstract:
:The widespread use of butylated hydroxyanisole (I) and butylated hydroxytoluene (II) as food antioxidants recently has been criticized by the Food and Drug Administration because of their pharmacological and toxicological effects. Interest also has arisen recently in the use of these compounds as anticancer agents. The purposes of this study were to evaluate the pharmacokinetics of I and II in rabbits and to compare their physicochemical properties with their disposition kinetics. It was found that I has a disposition half-life of approximately 1 hr, compared to 11 days for II. These differences are explained in terms of their lipid solubility and protein binding characteristics.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
El-Rashidy R,Niazi Sdoi
10.1002/jps.2600691233subject
Has Abstractpub_date
1980-12-01 00:00:00pages
1455-7issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43509-9journal_volume
69pub_type
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更新日期:2014-01-01 00:00:00
abstract::A diffusion model for the percutaneous absorption of a solute through the skin is developed for the specific case of a constant donor concentration with a finite removal rate from the receptor due to either perfusion rate or sampling. The model has been developed to include a viable epidermal resistance and a donor-st...
journal_title:Journal of pharmaceutical sciences
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更新日期:1999-11-01 00:00:00
abstract::We previously reported nonaqueous silicone elastomer gels (SEGs) for sustained vaginal administration of the CCR5-targeted entry inhibitor maraviroc (MVC). Here, we describe chemically modified SEGs (h-SEGs) in which the hydrophobic cyclomethicone component was partially replaced with relatively hydrophilic silanol-te...
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更新日期:1993-07-01 00:00:00
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abstract::Oxidation of 7,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline with potassium permanganate in acetone afforded 7,8-dimethoxy-3,4-dihydroisoquinoline as the primary product. Hence, oxidation of the appropriate secondary nonphenolic 7,8-dioxygenated tetrahydroisoquinoline alkaloid is thus a facile method for the generation o...
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abstract::Daunorubicin (DAUN) and doxorubicin (DOX) are used to treat a variety of cancers. The use of DAUN and DOX is hampered by the development of cardiotoxicity. Clinical evidence suggests that patients with leukemia and Down syndrome are at increased risk for anthracycline-related cardiotoxicity. Carbonyl reductases and al...
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