HLA typing in women with breast implants.

Abstract:

:Since the 1970s, anecdotal reports have described a relatively small number of women who received silicone gel breast implants and later developed either a recognized rheumatologic disease or unexplained symptoms suggestive of an autoimmune disorder. The study reported here examined whether there is any association between the symptoms seen in implant patients and HLA molecules. One-hundred and ninety-nine subjects were evaluated by HLA typing: symptomatic patients with implants (group I, n = 77), asymptomatic women with implants (group II, n = 37), healthy female volunteers without implants (group III, n = 54), and fibromyalgia patients without implants (group IV, n = 31). A statistically significant 68 percent of group I were positive for HLA-DR53, compared with 35 percent of group II and 52 percent of group III. The fibromyalgia patients were strikingly similar to group I women in terms of HLA-DR molecules, with 65 percent of group IV being positive for DR53. Group I also had a statistically significant increased frequency of HLA-DQ2. Asymptomatic women with implants (group II) had an increased frequency of DR1 and DQ1. In addition, 42 percent of symptomatic patients with implants formed autoantibodies to their own B cells; of these, 81 percent were DR53-positive. Although frequencies of capsular contracture and implant rupture were not significantly different in the two groups with implants, there were statistically significant associations in group I between contractures and ruptures and the presence of DR53 and B-cell autoantibodies. These data suggest that symptomatic patients with implants share important genetic characteristics (primarily HLA-DR53 positivity) that differentiate them from their asymptomatic counterparts. DR53 may be a marker of women who are predisposed by their HLA genotype to develop symptoms following exposure to silicone gel breast implants.

journal_name

Plast Reconstr Surg

authors

Young VL,Nemecek JR,Schwartz BD,Phelan DL,Schorr MW

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1497-519; discussion 1520

issue

7

eissn

0032-1052

issn

1529-4242

journal_volume

96

pub_type

杂志文章
  • Update on ischemia-reperfusion injury for the plastic surgeon: 2011.

    abstract::Ischemia-reperfusion injury occurs when tissue is reperfused following a prolonged period of ischemia. It is a subject of interest to plastic surgeons involved in replantation, free tissue transfer, and composite tissue allotransplantation, as it can have a significant impact on the overall success of these procedures...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e318230c57b

    authors: Wang WZ,Baynosa RC,Zamboni WA

    更新日期:2011-12-01 00:00:00

  • The use of adipose tissue-derived stem cells within a dermal substitute improves skin regeneration by increasing neoangiogenesis and collagen synthesis.

    abstract:BACKGROUND:Surgical treatment of injuries with loss of skin tissue has improved significantly with the advent of regenerative medicine and tissue bioengineering, and the use of stem cells and dermal substitutes. The success of tissue regeneration depends on optimal local vascularization and the successful integration o...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182547e04

    authors: Meruane MA,Rojas M,Marcelain K

    更新日期:2012-07-01 00:00:00

  • Ipsilateral island fibula transfer for segmental tibial defects: antegrade and retrograde fashion.

    abstract::Five patients with segmental tibial defects whose contralateral fibula could not be used as a donor were treated with ipsilateral island fibular transfer in an antegrade or retrograde fashion. Antegrade-flow pedicled flaps based on the peroneal vessel as in the conventional free flap were used for the proximal or midd...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199802000-00017

    authors: Chung YK,Chung S

    更新日期:1998-02-01 00:00:00

  • Mental health histories and psychiatric medication usage among persons who sought cosmetic Surgery.

    abstract::This retrospective chart review study examined the mental health histories and psychiatric medication usage of persons who sought cosmetic surgery. The medical records of 232 patients who had undergone a consultation for a cosmetic procedure were reviewed. The rates of self-reported psychiatric disorders and of psychi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000142999.86432.1f

    authors: Sarwer DB,Zanville HA,LaRossa D,Bartlett SP,Chang B,Low DW,Whitaker LA

    更新日期:2004-12-01 00:00:00

  • Experimental effects of heparin or magnesium sulfate on the patency of microvascular anastomoses.

    abstract::Partial amputations of the hind legs were done in 44 rats. The femoral arteries and veins were repaired by microvascular techniques. The systemic use of heparin, the local use of magnesium sulfate, and the combined use of the two drugs, were evaluated as to their influence on preventing thrombosis in these microvascul...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197505000-00018

    authors: Engrav LH,Benjamin CI,Crandall H,Perry JF

    更新日期:1975-05-01 00:00:00

  • Rupture of inflated breast implants in closed compression capsulotomy: case report.

    abstract::A case is reported of bilateral rupture of inflatable implants from a closed capsulotomy, with ingrowth of fibrous tissue through the inflation valves. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197706000-00023

    authors: Feliberti MC,Arrillaga A,Colon GA

    更新日期:1977-06-01 00:00:00

  • Myocutaneous free-flap transfer. Anatomical and experimental considerations.

    abstract::If there is a strongly dominant vascular pedicle, a muscle may be suitable for transfer as a free myocutaneous flap. The minor vascular pedicle(s) may contribute significantly to the arterial blood flow to the overlying skin, however. The concept of doing a delay procedure (ligating the dominant pedicle) to increase t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197808000-00002

    authors: Mathes SJ,Vasconez LO

    更新日期:1978-08-01 00:00:00

  • The "knot twist": a new method of securing wire loops--an assessment of mechanical properties.

    abstract::A model simulating intraosseous wire fixation was used to assess different methods of securing wire loops. Square knotting, twisting, and a new method, the "knot twist," were assessed. The importance of anchoring the butt ends of twisted wire is emphasized. A new, convenient technique of wire fixation is described. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Green RA,Zins JE

    更新日期:1988-06-01 00:00:00

  • Various methods of breast reconstruction after mastectomy: an economic comparison.

    abstract::This study is an economic comparison of various methods of breast reconstruction after mastectomy. The hospital bills of 287 patients undergoing breast reconstruction at three institutions from June of 1988 to March of 1991 were analyzed. The procedures examined included mastectomy, implant and tissue-expander reconst...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199307000-00011

    authors: Elkowitz A,Colen S,Slavin S,Seibert J,Weinstein M,Shaw W

    更新日期:1993-07-01 00:00:00

  • Plagiocephaly: differential diagnosis based on endocranial morphology.

    abstract::Plagiocephaly is a descriptive term that connotes an asymmetrically oblique or twisted head. Such cranial dysmorphology has a number of etiologies, the most common of which are unicoronal synostosis, unilambdoid synostosis, and plagiocephaly without synostosis. Use of the term plagiocephaly in the literature is often ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199602000-00003

    authors: Lo LJ,Marsh JL,Pilgram TK,Vannier MW

    更新日期:1996-02-01 00:00:00

  • Patient-reported outcome measures in plastic surgery: use and interpretation in evidence-based medicine.

    abstract::Understanding patients' perceptions of surgical results and their impacts on quality of life is of primary importance in plastic surgery, as procedures are largely performed to improve either appearance or function. Patient-reported outcome measures are questionnaires specifically designed to quantify aspects of healt...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e3182063276

    authors: Pusic AL,Lemaine V,Klassen AF,Scott AM,Cano SJ

    更新日期:2011-03-01 00:00:00

  • Lamellar split osteotomy: a new craniofacial technique.

    abstract::Craniofacial osteotomies have by convention been bilamellar translocations of the entire substance of the dysmorphic bone. This approach limits the surgeon by reducing the stable bone mass available for fixation, creating dependence on concave surfaces. Most important, it changes the bony topography that determines th...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Salyer KE,Hall CD,Joganic EF

    更新日期:1990-11-01 00:00:00

  • The split calvarial graft donor site in the elderly: a study in cadavers.

    abstract::In 37 cadavers of average age 75.5 years, the calvarium was studied. In all, the diploe and outer and inner tables were found to be definite layers. Although the parietal bone thickness did decrease with age in this study, there was no correlation between age and the outer table or diploe thickness. No significant cha...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198907000-00006

    authors: Sullivan WG,Smith AA

    更新日期:1989-07-01 00:00:00

  • Single-stage repair of asymmetrical bilateral cleft lip with contralateral lesser form defects.

    abstract:BACKGROUND:Complete or incomplete cleft lip may include a contralateral lesser form of incomplete cleft lip to give rise to an asymmetrical bilateral cleft lip deformity. The principle of simultaneous bilateral cleft repair remains an area of contention with regard to asymmetrical cases, including a lesser form deformi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182402f50

    authors: Bezuhly M,Fisher DM

    更新日期:2012-03-01 00:00:00

  • Gene expression of TGF-beta, TGF-beta receptor, and extracellular matrix proteins during membranous bone healing in rats.

    abstract::Poorly healing mandibular fractures and osteotomies can be troublesome complications of craniomaxillofacial trauma and reconstructive surgery. Gene therapy may offer ways of enhancing bone formation by altering the expression of desired growth factors and extracellular matrix molecules. The elucidation of suitable can...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200005000-00018

    authors: Steinbrech DS,Mehrara BJ,Rowe NM,Dudziak ME,Luchs JS,Saadeh PB,Gittes GK,Longaker MT

    更新日期:2000-05-01 00:00:00

  • Bone morphogenetic protein excipients: comparative observations on poloxamer.

    abstract::Clinicians await the availability of synthetic bioimplants that will replace the need for autogeneic bone grafts in bone reconstructive surgery. For more than a decade, researchers have evaluated delivery vehicles for the tissue morphogen bone morphogenetic protein. The object of this investigation was to measure indu...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200002000-00023

    authors: Clokie CM,Urist MR

    更新日期:2000-02-01 00:00:00

  • Carpal tunnel release through a limited skin incision under direct visualization using a new instrument, the carposcope.

    abstract::A new surgical technique with a set of instruments has been developed for the release of carpal tunnel. The technique allows division of the transverse carpal ligament through a short transverse skin incision (1.5 to 2 cm) of the wrist flexion crease under direct visualization. The technique has been used on 237 patie...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199608000-00016

    authors: Lee H,Jackson TA

    更新日期:1996-08-01 00:00:00

  • Increasing the volume of vascularized tissue formation in engineered constructs: an experimental study in rats.

    abstract::The authors have previously described a model of in vivo tissue generation based on an implanted, microsurgically created vessel loop in a plastic chamber (volume, 0.45 ml) containing a poly(DL-lactic-co-glycolic acid) (PLGA) scaffold. Tissue grew spontaneously in association with an intense angiogenic sprouting from ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000046034.02158.EB

    authors: Hofer SO,Knight KM,Cooper-White JJ,O'Connor AJ,Perera JM,Romeo-Meeuw R,Penington AJ,Knight KR,Morrison WA,Messina A

    更新日期:2003-03-01 00:00:00

  • Osteocutaneous flap prefabrication in rats.

    abstract::Composite tissue defects may involve skin, mucosa, muscle, and bone together or in combinations of two or three of these tissues. Defects involving bone and skin are frequently encountered. Osteocutaneous flaps may be used to reconstruct these composite tissue defects. Sometimes, it is not possible to obtain a vascula...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000101062.00227.4F

    authors: Top H,Mavi A,Barutcu A,Yilmaz O

    更新日期:2004-02-01 00:00:00

  • Analyzing Regional Differences over a 15-Year Trend of One-Stage versus Two-Stage Breast Reconstruction in 941,191 Postmastectomy Patients.

    abstract:BACKGROUND:Implant-based reconstruction is the predominant form of breast reconstruction, with the two-stage tissue expander/implant approach being the most popular. Recently, the direct-to-implant, one-stage breast reconstruction procedure has gained momentum. In this study, national and regional trends across the Uni...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000002267

    authors: Kamali P,Koolen PGL,Ibrahim AMS,Paul MA,Dikmans RE,Schermerhorn ML,Lee BT,Lin SJ

    更新日期:2016-07-01 00:00:00

  • Scalp stretching with a tissue expander for closure of scalp defects.

    abstract::The authors show a way of reconstruction of scalp defects with excellent results using a tissue expander. This method creates "new" scalp tissue for coverage of defects with normal hair-bearing skin having a dense and even growth of hair. The hairs grow in the correct direction. The authors also show that almost all o...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198504000-00025

    authors: Nordström RE,Devine JW

    更新日期:1985-04-01 00:00:00

  • Effect of proteins depletion on the surviving length in experimental skin flaps.

    abstract::Protein depletion appears to augment, rather than decrease, the length of a skin flap surviving in rats. We were able to document a lowering of serum viscosity in these animals. The augmentation of flap survival produced by protein depletion may even be greater than that produced by the delay phenomenon. A reduction i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197804000-00015

    authors: Ruberg RL,Falcone RE

    更新日期:1978-04-01 00:00:00

  • Bone regeneration within a coralline hydroxyapatite implant.

    abstract::The hypothesis that incomplete resorption of osteons in an autogenous cortical bone graft may limit its replacement by new bone regeneration was explored by implanting a hydroxyapatite replica of a coral skeletal structure into bone gaps. This implant contained channels and interconnections similar to those in osteon-...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197905000-00004

    authors: Holmes RE

    更新日期:1979-05-01 00:00:00

  • Heel coverage with a T-shaped distally based sural island fasciocutaneous flap.

    abstract::Two cases of heel damage that were reconstructed with a T-shaped distally based island fasciocutaneous flap in the sural area are presented. This flap is vascularized by the distal sural arterial network. The advantages of this flap are: (1) It does not sacrifice any major arteries of the leg. (2) It covers the whole ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199404000-00036

    authors: Hyakusoku H,Tonegawa H,Fumiiri M

    更新日期:1994-04-01 00:00:00

  • Gluteal fold V-Y advancement flap for vulvar and vaginal reconstruction: a new flap.

    abstract:BACKGROUND:Soft-tissue reconstruction following vulvar cancer resection is a difficult challenge because of the functional, locational, and cosmetic importance of this region. Although numerous flaps have been designed for vulvar reconstruction, each has its disadvantages. METHODS:The authors introduce the gluteal fol...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000227683.47836.28

    authors: Lee PK,Choi MS,Ahn ST,Oh DY,Rhie JW,Han KT

    更新日期:2006-08-01 00:00:00

  • Long-term persistence of tissue-engineered adipose flaps in a murine model to 1 year: an update.

    abstract:BACKGROUND:Tissue engineering of patient-specific adipose tissue has the potential to revolutionize reconstructive surgery. Numerous models have been described for the production of adipose tissue with success in the short term, but little has been reported on the stability of this tissue-engineered fat beyond 4 months...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181b59ff6

    authors: Findlay MW,Messina A,Thompson EW,Morrison WA

    更新日期:2009-10-01 00:00:00

  • Early passive mobilization after digital nerve repair and grafting in a fresh cadaver.

    abstract::In the clinical management of combined tendon and nerve injuries, there are competing treatment strategies. Isolated tendon injuries should be rapidly mobilized after repair to prevent adhesion formation, whereas isolated nerve repairs are usually immobilized to prevent disruption and to allow axon regrowth. Recommend...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200108000-00017

    authors: Chao RP,Braün SA,Ta KT,Palesty JA,Mine R,Syed SA,Chang DJ,Thomson JG

    更新日期:2001-08-01 00:00:00

  • Comparison of vertical and oblique rectus abdominis myocutaneous flaps for pelvic, perineal, and groin reconstruction.

    abstract:BACKGROUND:Wound complications after perineal and groin obliterative procedures are a significant cause of morbidity, particularly following chemoradiation therapy. Vertical and, increasingly, oblique rectus abdominis myocutaneous flaps have been used to fill potential dead space and bring healthy, vascularized tissue ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000324

    authors: Combs PD,Sousa JD,Louie O,Said HK,Neligan PC,Mathes DW

    更新日期:2014-08-01 00:00:00

  • Molecular and cellular characterization of mouse calvarial osteoblasts derived from neural crest and paraxial mesoderm.

    abstract:BACKGROUND:Cranial skeletogenic mesenchyme is derived from two distinct embryonic sources: mesoderm and cranial neural crest. Previous studies have focused on molecular and cellular differences of juvenile and adult osteoblasts. METHODS:To further understand the features of mouse-derived juvenile osteoblasts, the auth...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000279491.48283.51

    authors: Xu Y,Malladi P,Zhou D,Longaker MT

    更新日期:2007-12-01 00:00:00

  • What's New in Acellular Dermal Matrix and Soft-Tissue Support for Prosthetic Breast Reconstruction.

    abstract::Of the nearly 90,000 implant-based breast reconstructions performed in the United States, the majority use internal soft-tissue support. Aesthetically, these constructs may allow for better positioning of prosthesis, improve lower pole expansion, and increase projection. They may have particular utility in direct-to-i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000003950

    authors: Kim JYS,Mlodinow AS

    更新日期:2017-11-01 00:00:00