Fetal versus adult PreB or B cells: the human VH repertoire.

abstract：:Bisphosphonates are widely used in the management of metastatic disease to bone and in diseases of altered bone turnover. Recently, multiple-case series and retrospective studies have established a relationship between necrotic bone lesions localized to the jaw and the use of chronic bisphosphonate therapy. This condi...

journal_title：Annals of the New York Academy of Sciences

authors： Ruggiero SL

更新日期：2011-02-01 00:00:00

abstract：:In the pituitary of mammals, the GnRH receptor (GnRHR) plays crucial roles in the neuroendocrine control of reproductive function. This receptor is specifically expressed by the gonadotrope cells scattered among the five other endocrine cell types constituting the anterior pituitary; it is also expressed in other orga...

journal_title：Annals of the New York Academy of Sciences

authors： Schang AL,Counis R,Magre S,Bleux C,Granger A,Ngô-Muller V,Chenut MC,Ishaq M,Cohen-Tannoudji J,Laverrière JN

更新日期：2011-03-01 00:00:00

abstract：:The initial phase of vessel formation is the establishment of nascent endothelial tubes from mesodermal precursor cells. Development of the vascular epithelium is examined using the transcription factor TAL1 as a marker of endothelial precursor cells (angioblasts), and a functional assay based on intact, whole-mounted...

journal_title：Annals of the New York Academy of Sciences

authors： Drake CJ,Hungerford JE,Little CD

更新日期：1998-10-23 00:00:00

abstract：:The factor Xa inhibitor apixaban is one of the novel anticoagulants to emerge as alternatives to long-standing standards of care that include low-molecular-weight heparin and warfarin. The development of apixaban reflects a strategy to optimize the clinical pharmacology profile, dosing posology, trial designs, and sta...

journal_title：Annals of the New York Academy of Sciences

authors： Hanna MS,Mohan P,Knabb R,Gupta E,Frost C,Lawrence JH

更新日期：2014-11-01 00:00:00

abstract：:To gain better insight into mass transfer problems in encapsulated cell systems requires a combination of experimental investigations and mathematical modeling. Specific mass transfer studies are reviewed including oxygen transfer in immobilized animal cell culture bioreactors, modeling of polymer droplet formation an...

journal_title：Annals of the New York Academy of Sciences

authors： Goosen MF

更新日期：1999-06-18 00:00:00

abstract：:Hereditary adrenal pheochromocytoma is caused by germline mutations in RET, VHL, SDHB, SDHD, and NF1. As these genes differ in function, so may their pheochromocytoma phenotypes, suggesting gene-specific patterns of age-related progression to pheochromocytoma. This possibility was explored for gene carriers with a lif...

journal_title：Annals of the New York Academy of Sciences

authors： Machens A,Brauckhoff M,Gimm O,Dralle H

更新日期：2006-08-01 00:00:00

abstract：:The purpose of the present experiment was to determine if there is a factor in serum of patients with myasthenia gravis (MG) that interferes with binding of (125I)-alpha-bungarotoxin to acetylcholine receptors of normal mouse diaphragm. Diaphragms were incubated aerobically for 1 hour in either Krebs-Henseleit solutio...

journal_title：Annals of the New York Academy of Sciences

authors： Keesey J,Shaikh I,Wolfgram F,Chao LP

更新日期：1976-01-01 00:00:00

abstract：:Emotional or physical stress triggers Tako-tsubo cardiomyopathy in postmenopausal females, which is characterized by an elevation of the ST segment in the electrocardiogram (ECG) and left ventricular apical ballooning in the left ventriculogram (LVG). Immobilization stress (IMO) of rats can reproduce these ECG and LVG...

journal_title：Annals of the New York Academy of Sciences

authors： Ueyama T

更新日期：2004-06-01 00:00:00

abstract：:Chronic hypoxic stimulation in mammals can induce several phenotypic changes, such as polycythemia, pulmonary vascular changes, pulmonary hypertension, and carotid body (CB) enlargement. These phenotypic alterations provide a tool to test whether an oxygen sensor candidate is involved in an organism's response to envi...

journal_title：Annals of the New York Academy of Sciences

authors： Baysal BE

更新日期：2006-08-01 00:00:00

abstract：:5-Lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are two enzymes that are critical for the synthesis of eicosanoids, the inflammatory metabolites of arachidonic acid. Both 5-LOX and COX-2 are expressed in the brain, including in CNS neurons. The physiologic role of these proteins in neuronal functioning is not clea...

journal_title：Annals of the New York Academy of Sciences

authors： Manev H,Uz T,Manev R,Zhang Z

更新日期：2001-06-01 00:00:00

abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...

journal_title：Annals of the New York Academy of Sciences

authors： Nademanee K,Singh BN

更新日期：1988-01-01 00:00:00

abstract：:This paper presents a video-based eye-tracking method, ideally deployed via a mobile device or laptop-based webcam, as a tool for measuring brain function. Eye movements and pupillary motility are tightly regulated by brain circuits, are subtly perturbed by many disease states, and are measurable using video-based met...

journal_title：Annals of the New York Academy of Sciences

authors： Adhikari S,Stark DE

更新日期：2017-01-01 00:00:00

abstract：:Ovarian failure is heterogeneous, both in cause and in phenotype. Women whose menses cease prior to age 40 years and have menopausal FSH levels are traditionally considered by clinicians to have the diagnosis of "premature ovarian failure" (POF). In fact, however, the ovarian function in this disorder is in reality a ...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson JL

更新日期：2008-01-01 00:00:00

abstract：:The production of nitric oxide (NO) emerges as an essential determinant in auto- and paracrine signaling. NO is known to be generated under inflammatory conditions, carcinogenesis, and circulatory shock. The large amount of NO produced in response to cytokines plays an important role in inflammatory conditions. Cycloo...

journal_title：Annals of the New York Academy of Sciences

authors： Shin JI,Lee YK,Kim YM,Hwang JT,Park OJ

更新日期：2007-01-01 00:00:00

abstract：:The APC protein is a crucial regulator of intestinal cell growth, and mutations in the APC gene are a common initial event in the process of human colorectal carcinogenesis. Animals bearing germline mutations in Apc are therefore important models for human colorectal cancer. These animals have been used both to unders...

journal_title：Annals of the New York Academy of Sciences

authors： Bertagnolli MM

更新日期：1999-01-01 00:00:00

abstract：:In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of t...

journal_title：Annals of the New York Academy of Sciences

authors： Borman RA,Burleigh DE

更新日期：1997-05-30 00:00:00

abstract：:Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cong Y,Liu C,Weaver CT,Elson CO

更新日期：2004-12-01 00:00:00

abstract：:Fertility drugs (FD) are spreading worldwide fast and therefore many studies have reviewed the possible association between the use of these drugs and cancer. Since the drugs used for ovulation induction during in vitro fertilization (IVF) like hCG, hMG, rFSH increase the levels of gonadal hormones, concerns have grow...

journal_title：Annals of the New York Academy of Sciences

authors： Kanakas N,Mantzavinos T

更新日期：2006-12-01 00:00:00

abstract：:Current tuberculosis (TB) therapies take too long and the regimens are complex and subject to adverse effects and drug-drug interactions with concomitant medications. The emergence of drug-resistant TB strains exacerbates the situation. Drug discovery for TB has resurged in recent years, generating compounds (hits) wi...

journal_title：Annals of the New York Academy of Sciences

authors： Mdluli K,Kaneko T,Upton A

更新日期：2014-09-01 00:00:00

abstract：:The measurement of autoantibodies specific for double-stranded DNA (anti-dsDNA) is a useful tool for the diagnosis and the prognosis of systemic lupus erythematosus (SLE). A new quantitative enzyme-linked immunosorbent assay (ELISA), ORG anti-dsDNA, is recently available for the determination of anti-dsDNA antibodies....

journal_title：Annals of the New York Academy of Sciences

authors： Bardin N,Ragot C,Sanmarco M

更新日期：2007-08-01 00:00:00

abstract：:It is thought that neuronal activity in orbitofrontal cortex (OFC) represents the value of anticipated reward; however activity in many other brain areas also seems to reflect expected reward value. For example, we have shown that in monkeys performing a memory-guided saccade task for a reward of variable size, activi...

journal_title：Annals of the New York Academy of Sciences

authors： Roesch MR,Olson CR

更新日期：2007-12-01 00:00:00

abstract：:The following on proton pump inhibitors (PPIs) and chemoprevention in relation to Barrett's esophagus includes commentaries on 48-h pH monitoring, pH-impedence, bile acid testing, dyspepsia, long/short segment Barrett's esophagus, nonerosive reflux disease (NERD), functional heartburn, dual-release delivery PPIs, imme...

journal_title：Annals of the New York Academy of Sciences

authors： Richter JE,Penagini R,Tenca A,Pohl D,Dvorak K,Goldman A,Savarino E,Zentilin P,Savarino V,Watson JT,Wong RK,Pace F,Casini V,Peura DA,Herzig SJ,Kamiya T,Pelosini I,Scarpignato C,Armstrong D,DeVault KR,Bechi P,Tadd

更新日期：2011-09-01 00:00:00

abstract：:The recent literature providing insights from neuroscience and evolutionary biology into how individuals perceive risky choice situations represents a "second wave" of findings that recapitulates as well as challenges the risk perception research begun in the 1980s, which relied on psychometric survey research. Gleani...

journal_title：Annals of the New York Academy of Sciences

authors： Finkel AM

更新日期：2008-04-01 00:00:00

abstract：:Over the last years, El Sistema--the Venezuelan project started in 1975 and now acknowledged worldwide as the most significant example of collective music education--has inspired a profusion of remarkable initiatives on all continents. From the original impulse by founder José Antonio Abreu, strong social principles o...

journal_title：Annals of the New York Academy of Sciences

authors： Majno M

更新日期：2012-04-01 00:00:00

abstract：:The disturbances in the balance of pro- and antifibrinolytic activity, as observed in AAA and obesity, respectively, have considerable potential for influencing both intra- and extravascular fibrinolytic events and may be causally related to the development of vascular disease. For example, the wall of the aortic athe...

journal_title：Annals of the New York Academy of Sciences

authors： Samad F,Schneiderman J,Loskutoff D

更新日期：1997-04-15 00:00:00

abstract：:Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

journal_title：Annals of the New York Academy of Sciences

authors： Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

更新日期：2009-04-01 00:00:00

abstract：:Reproduction usually is characterized by a mean-population fecundity pattern. Such a pattern has a maximum at earlier ages and a subsequent gradual decline in egg production. It is shown that individual fecundity trajectories do not follow such a pattern. In particular, the regular individual fecundity pattern has no ...

journal_title：Annals of the New York Academy of Sciences

authors： Novoseltsev VN,Arking R,Carey JR,Novoseltseva JA,Yashin AI

更新日期：2004-06-01 00:00:00

abstract：:Certain livestock diseases in sub-Saharan Africa, such as foot-and-mouth disease are difficult to control because of the large numbers of infected wildlife hosts. These wildlife disease reservoirs form a continuous hazard of transmittal of the diseases to domestic livestock, which limits the access of livestock produc...

journal_title：Annals of the New York Academy of Sciences

authors： Sutmoller P

更新日期：2002-10-01 00:00:00

abstract：:Apoptosis in T and B lymphocytes is a major element controlling the immune response. Activation induced cell death (AICD) in T cells is a main mechanism for maintaining peripheral tolerance and for limiting an ongoing immune response. AICD is initiated by antigen reengagement of the T cell receptor (TCR), and mediated...

journal_title：Annals of the New York Academy of Sciences

authors： Delgado M,Ganea D

更新日期：2000-01-01 00:00:00

abstract：:Sleep disturbances are prominent complaints of PTSD patients. Some, but not all, of the polysomnographic studies support the occurrence of sleep disruption. The main dimensions of sleep disturbance in the disorder relate to arousal regulation and REM-related functions of dreaming and memory processing. Both of these i...

journal_title：Annals of the New York Academy of Sciences

authors： Mellman TA

更新日期：1997-06-21 00:00:00