Abstract:
OBJECTIVES:The halo sign refers to a zone of ground-glass attenuation surrounding a pulmonary nodule. Pulmonary metastatic nodules exhibiting a halo sign are seen mainly in hypervascular tumours. We describe the appearance of a halo sign following treatment of adoptive transfer of autologous tumour-infiltrating lymphocytes (TIL) to melanoma patients with lung metastases. METHODS:The study included 29 melanoma patients with pulmonary metastases who received TIL therapy. Pre- and post-treatment chest CTs were retrospectively reviewed for the presence of a halo sign and its correlation with therapeutic response. RESULTS:A pulmonary halo sign was not seen in any pre-treatment CT. It was observed in four of 12 patients who responded to the therapy but not in those who failed to respond. Significant differences were found between response ratio in patients in whom post-TIL halo sign appeared compared with those without the halo sign (p = 0.02). CONCLUSIONS:The appearance of a CT halo sign in melanoma with lung metastases following TIL therapy may indicate antitumoral effect and a good response to therapy. Our findings emphasize the importance of applying new assessment criteria for immunological anticancer therapies. KEY POINTS:Tumour-infiltrating lymphocytes (TIL) in melanoma patients is a promising novel immunotherapy. Post-therapy pulmonary halo sign appeared in one-third of TIL responders . Pulmonary halo sign may serve as an imaging marker for antitumoral activity.
journal_name
Eur Radioljournal_title
European radiologyauthors
Shrot S,Schachter J,Shapira-Frommer R,Besser MJ,Apter Sdoi
10.1007/s00330-014-3129-6subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1251-6issue
6eissn
0938-7994issn
1432-1084journal_volume
24pub_type
杂志文章abstract:OBJECTIVE:The aim of the study was to assess the performance and diagnostic value of a dual energy CT approach to reduce metal artefacts in subjects with metallic implants. METHODS:31 patients were examined in the area of their metallic implants using a dual energy CT protocol (filtered 140 kVp and 100 kVp spectrum, t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2062-1
更新日期:2011-07-01 00:00:00
abstract::There are a number of conditions affecting the vagina and vulva that can be optimally assessed with the use of high-resolution magnetic resonance imaging (MRI). This paper gives a suggested protocol for MRI technique and sequences for imaging the pelvis and perineum and reviews the MRI appearances of many of the commo...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-008-0865-5
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:To correlate hepatic and splenic CT perfusion parameters with hepatic venous pressure gradient (HVPG) measurements in patients with cirrhosis. METHODS:Twenty-one patients with cirrhosis (males, 17; females, 4; mean ± SD age, 57 ± 7 years) underwent hepatic and splenic perfusion CT on a 320-detector row volu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4788-x
更新日期:2017-10-01 00:00:00
abstract::The purpose of this study was to compare LV function and mass quantification derived from cardiac dual-source CT (DSCT) exams with those obtained by MRI in heart transplant recipients. Twelve heart transplant recipients who underwent cardiac DSCT and MRI examination were included. Double-oblique short-axis 8-mm slice ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-0949-2
更新日期:2008-09-01 00:00:00
abstract::Our objective was to study Gd-EOB-DTPA for the characterization of focal liver lesions by means of dynamic MR imaging. A double-blind and randomized dose-ranging phase-2 clinical trial was performed in 31 patients (liver metastases n = 23, hepatocellular carcinoma n = 4, and hemangioma n = 4) at a field strength of 1....
journal_title:European radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003300050150
更新日期:1997-01-01 00:00:00
abstract::Percutaneous thrombectomy (PT) is an established technique for the removal of acute thrombus in occluded arteries, veins and vascular grafts. Percutaneous thrombectomy can be used as an adjunctive treatment to other methods of thrombus removal such as thrombolysis or as sole therapy. The two main methods are percutane...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300101014
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and handling of abdominal MRI-guided biopsies in a 3-T MRI system. METHODS:Over a 1-year period, 50 biopsies were obtained in 47 patients with tumours of the upper abdominal organs guided by 3-T MRI with a large-bore diameter of 70 cm. Lesions in liver (47), spleen (1) and kidn...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1809-4
更新日期:2010-10-01 00:00:00
abstract::To overcome the limitations of the classical volume scoring method for quantifying coronary calcifications, including accuracy, variability between examinations, and dependency on plaque density and acquisition parameters, a mesh-based volume measurement method has been developed. It was evaluated and compared with th...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1181-9
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To review the diagnostic performance of MRI for detection of parametrial invasion (PMI) in cervical cancer patients. METHODS:MEDLINE and EMBASE databases were searched for studies providing diagnostic performance of MRI for detecting PMI in patients with cervical cancer. Studies published between 2012 and 20...
journal_title:European radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00330-017-4958-x
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To investigate whether whole-body diffusion-weighted imaging (WB-DWI) alone is adequate for detecting metastases in melanoma patients, or if standard WB contrast-enhanced magnetic resonance imaging (WB-ceMRI) is required. METHODS:Seventy-one WB-DWI studies were performed quarterly along with whole-body MRI ...
journal_title:European radiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00330-013-2968-x
更新日期:2013-12-01 00:00:00
abstract::The purpose was to assess the diagnostic accuracy of a hand-held Doppler ultrasound (US) machine for the bedside detection of liver and vascular abnormalities after liver transplantation in the intensive care unit. The IRB approved this study, and written informed consent was obtained from all patients or the patient'...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-009-1417-3
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To describe the characteristics of multifocal endosteal thickening in patients on bisphosphonate therapy. METHOD:A retrospective study of 68 patients with atypical femoral fractures (as defined by ASBMR) whilst on bisphosphonate therapy was performed. Femoral radiographs were assessed for: focal endosteal t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2587-y
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between paraspinal and psoas muscle volumes and acute osteoporotic or low-bone-mass compression fractures of the lumbar spine in postmenopausal women. METHODS:Patient data were retrieved retrospectively for postmenopausal women with L-spine magnetic resonance imaging (MRI) and...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06034-w
更新日期:2019-09-01 00:00:00
abstract:AIMS AND OBJECTIVES:Deep venous thrombosis (DVT) can be difficult to detect using CT due to poor and heterogeneous contrast. Dual-energy CT (DECT) allows iodine contrast optimization using noise-optimized monoenergetic extrapolations (MEIs) and iodine maps (IMs). Our aim was to assess whether MEI and IM could improve t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3544-8
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:The complexity of anatomical structure within the breast represents the ultimate limit to signal detection on a mammogram. To increase lesion conspicuity Digital Breast Tomosynthesis (DBT) has been recently proposed and several manufacturers are currently performing clinical trials. In this study we investiga...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-2041-y
更新日期:2011-06-01 00:00:00
abstract::The purpose of this study was to describe and characterize the MR imaging findings in a group of patients who underwent surgery for adhesive capsulitis. Twenty-four MR imaging studies in 24 consecutive patients with clinical evidence of adhesive capsulitis were performed prior to arthroscopic capsulotomy. There were 1...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1349-7
更新日期:2002-08-01 00:00:00
abstract::Magnetic resonance imaging is currently the gold standard in the assessment of brain myelination. The normal pattern of brain myelination conforms to a fixed chronological sequence. Focal accelerated myelination is a usual pathological state and previously has only been associated with Sturge-Weber syndrome. The purpo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-0044-x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To determine whether phase-contrast X-ray imaging can be used to visualise directly the accumulated extracellular matrix proteins associated with liver fibrosis in common bile duct ligated mice. METHODS:Twenty-six-week-old C57BL female mice were randomised into three groups. In groups 1 (n = 5) and 2 (n = 1...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2630-z
更新日期:2013-02-01 00:00:00
abstract::Despite its lack of specificity, magnetic resonance imaging (MRI) of the bone marrow has the potential to play a role in the management of patients with primary neoplastic disorders of the hematopoietic system, including lymphomas, leukemias and multiple myeloma. In addition to its use in the assessment of suspected s...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050548
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the added value of deep learning (DL) analysis of the left ventricular myocardium (LVM) in resting coronary CT angiography (CCTA) over determination of coronary degree of stenosis (DS), for identification of patients with functionally significant coronary artery stenosis. METHODS:Patients who un...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5822-3
更新日期:2019-05-01 00:00:00
abstract::The aim of this study was to revisit anal anatomy, to explain surgical terminology in perianal complications of Crohn disease, and to show the MR imaging findings of perianal fistulas and abscesses. To this end more than 200 patients were studied using surface coils (Helmholtz; phased array) at 1.0 and 1.5 T. Transver...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050248
更新日期:1997-01-01 00:00:00
abstract::The development and progression of a hepatocellular carcinoma (HCC) in a chronically diseased liver, i.e., the carcinogenesis, comprise a multistep and long-term process. Morphologically, this process is associated with the presence of distinct nodular lesions in the liver that are called 'preneoplastic lesions.' Thes...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-007-0602-5
更新日期:2007-10-01 00:00:00
abstract::Electron beam tomography (EBT) has been used for cardiac diagnosis and the quantitative assessment of coronary calcium since the late 1980s. The introduction of mechanical multi-slice spiral CT (MSCT) scanners with shorter rotation times opened new possibilities of cardiac imaging with conventional CT scanners. The pu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1746-y
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To evaluate percutaneous computed tomography (CT)-guided intracystic and intra-articular steroid injections for the treatment of lumbar facet joint cyst causing radicular pain. METHODS:A single-centre prospective study involving 120 consecutive patients with symptomatic lumbar facet joint cyst-induced radicu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2533-z
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To investigate potential relationships between diffusion kurtosis imaging (DKI)-derived parameters using whole-tumour volume histogram analysis and clinicopathological prognostic factors in patients with rectal adenocarcinoma. MATERIAL AND METHODS:79 consecutive patients who underwent MRI examination with re...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5094-3
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:To assess whether increases in amide proton transfer (APT)-weighted signal reflect the effects of tissue recovery from acidosis using transient rat middle cerebral artery occlusion (MCAO) models, compared to permanent occlusion models. MATERIALS AND METHODS:Twenty-four rats with MCAO (17 transient and seven...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5964-3
更新日期:2019-08-01 00:00:00
abstract::Renal cell carcinoma in a horseshoe kidney is an unusual entity. To our knowledge, only 123 cases have been published to date. We report the first bilateral case of two clear-cell carcinomas in an asymmetrically fused kidney. Optimum preservation of renal function after radical tumor removal requires accurate preopera...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050615
更新日期:1998-01-01 00:00:00
abstract::The aim of this study was to determine whether the intrarenal resistive index (RI) can be used for the diagnosis of acute obstruction in patients with renal colic and to determine whether the index is time-related. Seventy patients referred to the Emergency Department with acute renal colic and without known associate...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050568
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To report the results and implications for workflow following introduction of ESUR guidelines to screen for potential renal insufficiency (RI) in private practice with on-site creatinine measurements. METHODS:A total of 1,766 consecutive outpatients scheduled for contrast-enhanced CT (CECT) completed the ESU...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1754-2
更新日期:2010-08-01 00:00:00
abstract::The purpose of our study was to investigate whether quantitative diffusion-weighted images (DWI) were useful for monitoring the therapeutic response of primary bone tumors. We encountered 18 osteogenic and Ewing sarcomas. Magnetic resonance (MR) images were performed in all patients before and after therapy. We measur...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0342-y
更新日期:2006-12-01 00:00:00