Prostate-specific antigen and digital rectal examination in screening for prostate cancer: a community-based study.

Abstract:

:In this study, 1,027 healthy men over age 40 were screened for prostate cancer with digital rectal examinations (DRE) and prostate-specific antigen (PSA) levels. Findings were abnormal in 189 (18%). PSA levels alone were abnormal (> 4.0 ng/mL) in 111 men (12%), 60 men (8%) had abnormal DRE and normal PSA, and 18 men had abnormal results of both examinations. Of the 189 men, 176 (93%) were referred for follow-up studies, and 39 cases of prostate cancer were detected. Of the 60 men with abnormal findings on DRE and normal PSA levels, only 2 men (3%) were found to have prostate cancer. Twenty-two of the 107 men (21%) with PSA levels between 4.0 and 9.9 ng/mL and 14 of 22 men (64%) with a PSA level greater than 10 ng/mL had prostate cancer. Conversely, 36 of the 39 men (92%) with prostate cancer had a PSA level greater than 4.0 ng/mL. Of 18 men with both abnormal DRE and elevated PSA, 9 (50%) were found to have prostate cancer. Overall, the 39 men found to have prostate cancer constituted 3.8% of the population screened; 25 of them (64%) had disease clinically confined to the prostate. PSA in combination with DRE appears to be useful in detecting prostate cancer in its early stages. Prospective randomized trials must be completed to determine whether early detection will have an impact on overall mortality from prostate cancer.

journal_name

South Med J

journal_title

Southern medical journal

authors

Bretton PR

doi

10.1097/00007611-199407000-00009

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

720-3

issue

7

eissn

0038-4348

issn

1541-8243

journal_volume

87

pub_type

杂志文章
  • Massive bleeding in a Zenker's diverticulum.

    abstract::Massive bleeding from a pharyngoesophageal diverticulum is a rarely reported condition, with only two reported cases in the literature. This report describes a patient who had massive bleeding due to ulceration in the base of a pharyngoesophageal diverticulum, presumed to have been caused by chronic aspirin ingestion....

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199003000-00033

    authors: Hendren WG,Anderson T,Miller JI

    更新日期:1990-03-01 00:00:00

  • Clostridial bloodstream infections.

    abstract::In a ten-year review at a large community teaching hospital clostridia accounted for less than 1% of all positive bloodstream isolates (26 episodes in 25 patients). All but one of the isolates were clinically significant. Twenty-two patients (88%) had a serious underlying medical condition, and 17 of the episodes (65%...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198901000-00009

    authors: Ingram CW,Cooper JN

    更新日期:1989-01-01 00:00:00

  • Spontaneous aortic rupture in a malignant schwannoma.

    abstract::We have described a case of malignant schwannoma (MS) originating from the posterior mediastinum with subsequent pathologic rupture of the thoracic aorta. The patient presented with acute retrosternal pain radiating to the back, and she died on the day of admission. Necropsy revealed a large hemothorax and a tumor mas...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198011000-00035

    authors: Bambirra EA,Miranda D

    更新日期:1980-11-01 00:00:00

  • Total urinary estrogens in complicated pregnancies.

    abstract::One hundred fifty-seven pregnancies complicated by different degrees of diabetes, toxemia, and hypertension were studied with serial urinary placental estrogen determinations. A simple and fast method for total placental estrogen determination was used. The level of total estrogen excretion was related to Apgar score ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197510000-00009

    authors: Acosta AA,Besch NF,Besch PK,Buttram VC Jr,Hinkley C,Haller WS,Werch A

    更新日期:1975-10-01 00:00:00

  • Haemophilus influenzae endocarditis.

    abstract::Haemophilus influenzae endocarditis on a prosthetic valve has previously been reported only once. Routine physical and laboratory evaluation does not distinguish endocarditis from this organism from other causes of endocarditis. Our patient with prosthetic mitral valve endocarditis was successfully treated with antibi...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198506000-00041

    authors: Blair TP,Baker WP

    更新日期:1985-06-01 00:00:00

  • Prevalence of methicillin-resistant Staphylococcus aureus in a dermatology outpatient population.

    abstract:BACKGROUND:The number of methicillin-resistant STaphylococcus aureus (MRSA) infections in the hospital setting is increasing but little is known of its prevalence in the community. In a 1986-1987 study, the prevalence in dermatology outpatient clinics was <0.9%. This study reports changes in the same facilities from 19...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199804000-00011

    authors: Price MF,McBride ME,Wolf JE Jr

    更新日期:1998-04-01 00:00:00

  • Endocrinologic evaluation of impotence.

    abstract::Among 600 impotent men who had endocrine evaluation for androgen deficiency, thyroid deficiency, and hyperprolactinemia, 192 (32%) were found to have an endocrine abnormality. Androgen deficiency was divided into primary testicular failure and "hypothalamic-pituitary dysfunction" by an androgen quotient derived using ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198904000-00010

    authors: Baskin HJ

    更新日期:1989-04-01 00:00:00

  • Benign papillary mesothelioma of the peritoneum: a consideration in the differential diagnosis of peritoneal implants.

    abstract::We have reported a case of benign papillary mesothelioma of the peritoneum found incidentally during surgical exploration in a patient with rectal carcinoma. Clinicians and pathologists alike may find it difficult to differentiate this uncommon lesion from metastatic tumors. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198912000-00032

    authors: Tzanakakis G,McCully KS,Vezeridis MP

    更新日期:1989-12-01 00:00:00

  • Comorbidity of schizophreniform disorder and borderline personality disorder in an 18-year-old black woman.

    abstract::We describe a rare occurrence of comorbidity of schizophreniform disorder and borderline personality disorder as an initial patient presentation. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199803000-00013

    authors: Houry D,Johnson J,Cabrejos C

    更新日期:1998-03-01 00:00:00

  • Advances in Psoriasis.

    abstract::Psoriasis treatments range from topical treatments and phototherapy to oral systemic medications and injections. Despite good control of the disease when applying appropriate treatments (according to disease severity, insurance parameters, patient preference, and patients' ability to adhere), continued advancements wi...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.14423/SMJ.0000000000000596

    authors: Smith J,Cline A,Feldman SR

    更新日期:2017-01-01 00:00:00

  • Sporadic military meningococcal disease: a diversity of presentations.

    abstract::Thirty-four cases of meningococcal disease were identified in a retrospective survey of nine US Army posts in the southeastern United States from June 1977 to August 1979. Group B organisms predominated in dependents and civilian communities surrounding two of the posts, while active-duty personnel had a greater varie...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198102000-00007

    authors: Haburchak DR

    更新日期:1981-02-01 00:00:00

  • A case of paraneoplastic cerebellar ataxia secondary to renal cell carcinoma.

    abstract::A 64-year-old female patient presented with acute cerebellar ataxia. After ruling out vascular, infectious, metastatic, demyelinating, and medication etiologies, a paraneoplastic origin for her illness was determined. A renal mass was discovered and found to be renal cell carcinoma. Her symptoms resolved after a radic...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e31816bea80

    authors: Ammar H,Brown SH,Malani A,Sheth HK,Sollars EG,Zhou SX,Gupta C,Mughal S

    更新日期:2008-05-01 00:00:00

  • Maternal serum amylase and lipase profiles in pregnancy: determinations in both once-sampled and multisampled patient cohorts.

    abstract::The objective of this study was to determine the effect(s) of pregnancy and of advancing gestation on maternal serum amylase and lipase levels. Thus, serum amylase and lipase concentrations were quantitated in three groups of women. Groups included (1) 118 pregnant women whose serum amylase and lipase levels were meas...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007611-199602000-00008

    authors: Xydas NP,May JH,Henson MC

    更新日期:1996-02-01 00:00:00

  • Major venous anomalies complicating retroperitoneal surgery.

    abstract::Transposition of the inferior vena cava, duplication of the inferior vena cava, circumaortic renal collar, and retroaortic renal vein constitute the four most common major venous anomalies occurring in the retroperitoneum. Recent clinical cases are presented to review the embryogenesis, incidence, and clinical importa...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197910000-00012

    authors: Babaian RJ,Johnson DE

    更新日期:1979-10-01 00:00:00

  • Stomatococcus mucilaginosus catheter-related infection in an adolescent with osteosarcoma.

    abstract::Ours is apparently the first reported pediatric case of Stomatococcus mucilaginosus bacteremia. It is the second reported case of S mucilaginosus catheter-associated infection, but the first case successfully treated without removing the central venous catheter. This unusual organism should be added to the list of opp...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199103000-00029

    authors: Ascher DP,Bash MC,Zbick C,White C

    更新日期:1991-03-01 00:00:00

  • Role of biological agents in immune-mediated inflammatory diseases.

    abstract::A new era in the treatment of immune-mediated inflammatory disorders has begun with the clinical availability of anticytokine therapy. Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-alpha (infliximab, adalimumab, etanercept) and an interleukin-1 rece...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/01.SMJ.0000153119.37032.8B

    authors: Efthimiou P,Markenson JA

    更新日期:2005-02-01 00:00:00

  • Granular acute lymphoblastic leukemia in adults: report of a case and review of the literature.

    abstract::The diagnosis of granular acute lymphoblastic leukemia (ALL) can be problematic as the cytoplasmic granules found in many blast cells may mimic those seen in acute myelogenous leukemia (AML). This rare variant of B-cell ALL is more commonly diagnosed in children, but may occur in adults. We report a case of granular B...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.smj.0000231247.33762.f3

    authors: Fulcher JW,Allred TJ,Kulharya A,Satya-Prakash KL,Seigler M,Neibarger D,Mazzella FM

    更新日期:2006-08-01 00:00:00

  • Assessment and significance of Arthur Conan Doyle's medical writings.

    abstract::Doyle's medical writings represent a valuable contribution to both the scientific and nonscientific aspects of medicine of the late 19th Century. Up to the present, accounts of these writings have been few, and none of them have been evaluative of their scientific merit. Analysis of Doyle's writings on infectious dise...

    journal_title:Southern medical journal

    pub_type: 传,历史文章,杂志文章

    doi:10.1097/00007611-198211000-00023

    authors: Rodin AE,Key JD

    更新日期:1982-11-01 00:00:00

  • Predictive power of cardiovascular risk factors for detecting peripheral vascular disease.

    abstract:OBJECTIVES:Peripheral vascular disease (PVD) is underdiagnosed in primary care due to the absence of established criteria to warrant diagnostic testing. Our goal was to establish a risk factor hierarchy to enable earlier diagnosis of PVD. METHODS:Data sets of 142 patients with abnormal ankle brachial indices (ABI) wer...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.SMJ.0000141303.47034.46

    authors: Fine JJ,Hall PA,Richardson JH

    更新日期:2004-10-01 00:00:00

  • Malignant secondary parotid tumors.

    abstract::Malignant secondary parotid neoplasms are uncommon. Among 545 malignant parotid tumors, we found 52 (9%) that did not arise primarily in the parotid gland. Lymphomas or tumors of hematopoietic origin were excluded from this study. All patients had a parotid mass (two bilateral), one third of which were painful; 20% ha...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198109000-00007

    authors: Rees R,Maples M,Lynch JB,Rosenfeld L

    更新日期:1981-09-01 00:00:00

  • Intrathoracic chordoma presenting as a posterior mediastinal tumor.

    abstract::Chordomas are tumors originating from remnants of the notochord, most commonly found in the cranial and caudal regions. This is a report of the seventh intrathoracic chordoma in the world literature and the second to be reported in a woman. Histologically the physalipherous (blister-bearing) cell is characteristic of ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197501000-00029

    authors: Castellano GC,Johnston HW

    更新日期:1975-01-01 00:00:00

  • Impact of early recognition on outcome in nonpenetrating wounds of the small bowel.

    abstract::During a recent ten-year period, 20 patients were treated for nonpenetrating, small-bowel trauma requiring resection. Despite the relative infrequency of this injury, jejunoileal trauma must be suspected in all patients sustaining blunt force to the abdomen. Physical signs suggesting major intra-abdominal wounds usual...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198409000-00004

    authors: Maull KI,Reath DB

    更新日期:1984-09-01 00:00:00

  • Blood loss at vaginal delivery.

    abstract::Although the accurate assessment of blood loss at vaginal delivery is clinically important in terms of maternal morbidity and mortality, the quantity is usually underestimated. We present a simple, practical, and convenient method of quantitating blood loss at vaginal delivery. The method of vaginal delivery (spontane...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198602000-00013

    authors: Hill JA,Fadel HE,Nelson MC,Nelson RM,Nelson GH

    更新日期:1986-02-01 00:00:00

  • Artificial skin in the treatment of a large congenital nevus.

    abstract::An 8 year-old girl had a large congenital nevus involving the posterior thigh, leg, and foot. The nevus on non-weight-bearing areas was resected, and the areas were resurfaced with artificial skin and ultra-thin split-thickness grafts. A good result was ultimately achieved. Our management of this case and the relative...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Thomas WO,Rayburn S,LeBlanc RT,Powell RW,Luterman A

    更新日期:2001-03-01 00:00:00

  • Central pontine myelinolysis as a manifestation of the paraneoplastic syndrome.

    abstract::We have described a patient who had lung carcinoma, syndrome of inappropriate antidiuretic hormone, and central pontine myelinolysis (CPM). Although this association is well-known, it appears to be the first report having radiographic documentation of both the intracranial and intrathoracic abnormalities. When searchi...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199204000-00019

    authors: Hardjasudarma M,Husain F,Fowler M,Eisenberg RL,Mirfakhraee M

    更新日期:1992-04-01 00:00:00

  • Traumatic hypopituitarism: anterior hypophyseal insufficiency from indirect cranial trauma.

    abstract::We have reported a case of partial hypopituitarism involving deficient ACTH, LH, FSH, and growth hormone production and elevated prolactin. The hypopituitarism was caused by injury to the pituitary resulting from a parachute accident without direct craniocerebral trauma. The pathogenesis of this pituitary injury as ei...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Soules MR,Sheldon GW

    更新日期:1979-12-01 00:00:00

  • National survey of physicians' perception of the cause, complications, and management of gastroparesis.

    abstract:OBJECTIVES:Manifestations of gastroparesis are heterogeneous and clinical complications are poorly defined. Misconceptions of gastroparesis may be common. The objective was to determine physicians' perception of gastroparesis and identify areas that need further research and education. METHODS:A physician survey was p...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e318215fa5a

    authors: Briley LC,Harrell SP,Woosley A,Eversmann J,Wo JM

    更新日期:2011-06-01 00:00:00

  • The evaluation of an intermediate care--geriatric evaluation unit in a Veterans Administration Hospital.

    abstract::In response to the increasing care needs of geriatric patients and attendant hospital costs, the Nashville Veterans Administration Medical Center, which has 393 beds and admits 8400 patients annually, initiated an Intermediate Care Service in 1988. A geriatric team was formed, sharing staff and resources from existing...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Hauser B,Robinson J,Powers JS,Laubacher MA

    更新日期:1991-05-01 00:00:00

  • Cephalosporins for surgical prophylaxis: computer projections of intraoperative availability.

    abstract::Cephalosporin antibiotics are the most frequently used agents for surgical prophylaxis. Within this class are considerable pharmacokinetic variations that could have significant implications. We used a computer simulation of cephalosporin serum levels to describe concentrations achieved and maintained intraoperatively...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198508000-00018

    authors: Nix DE,DiPiro JT,Bowden TA Jr,Vallner JJ

    更新日期:1985-08-01 00:00:00

  • Emergency operations for Crohn's disease.

    abstract::Seventeen patients with Crohn's disease requiring emergency operative procedures disclosed important factors leading to successful outcome. In seven of the ten patients not known to have Crohn's disease, the history strongly suggested this diagnosis. Two patients died; three others had major complications, including t...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197810000-00010

    authors: Flint LM Jr

    更新日期:1978-10-01 00:00:00