Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II.


:Focal adhesion kinase (FAK) is a structurally unique nonreceptor protein-tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G-protein coupled receptors for mitogenic neuropeptides, and certain oncogene products. To gain evidence for specific processes in which FAK may be involved in vivo, a study was initiated to determine its expression pattern during mouse development. FAK expression was detected in early embryos and appeared to be distributed throughout all cell types at about the time of neurulation. Subsequent to neural tube closure, expression became particularly abundant in the developing vasculature. This included expression in the medial layer of arteries populated by smooth muscle cells. In vitro studies using cultured rat aortic vascular smooth muscle cells demonstrate that FAK phosphotyrosine content is dramatically elevated in response to plating cells onto the adhesive glycoprotein, fibronectin. Also, enhanced tyrosine phosphorylation of FAK is observed in these cells upon stimulation with the vasoconstrictor angiotensin II. Thus, in vascular smooth muscle cells, like fibroblasts, FAK appears to play a role in signaling mechanisms induced by extracellular matrix components as well as G-protein coupled receptor agonists. The combined results of this study suggest that signaling through FAK may play an important role in blood vessel morphogenesis and function.


J Cell Biochem


Polte TR,Naftilan AJ,Hanks SK




Has Abstract


1994-05-01 00:00:00












  • Repression of let-7b-5p prevents the development of multifidus muscle dysfunction by promoting vitamin D accumulation via upregulation of electron transfer flavoprotein alpha subunit in a rat model of multifidus muscle injury.

    abstract::Multifidus muscle dysfunction is associated with the multifidus muscle injury (MMI), which ultimately result in the low-back pain. Increasing evidence shows that microRNAs (miRs) may be involved in multifidus muscle dysfunction. In this study, we tested the hypothesis that downregulation of let-7b-5p may inhibit the m...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yu HM,Yao XD,Zhang RM,Zhuang HF,Wang PW,Li YZ

    更新日期:2018-11-01 00:00:00

  • The effects of peptides with estrogen-like activity on cell proliferation and energy metabolism in human derived vascular smooth muscle cells.

    abstract::Hormone replacement therapy (HRT) for post-menopausal symptoms in diabetes is associated with increased risk of coronary heart disease and stroke. Therefore, there is a need for new HRT with no adverse effects on diabetic post-menopausal women. We developed peptides as potential estrogen mimetic compounds and now we e...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Somjen D,Knoll E,Gayer B,Kasher R,Kohen F,Stern N

    更新日期:2010-08-01 00:00:00

  • 7-Dehydrocholesterol (7-DHC), But Not Cholesterol, Causes Suppression of Canonical TGF-β Signaling and Is Likely Involved in the Development of Atherosclerotic Cardiovascular Disease (ASCVD).

    abstract::For several decades, cholesterol has been thought to cause ASCVD. Limiting dietary cholesterol intake has been recommended to reduce the risk of the disease. However, several recent epidemiological studies do not support a relationship between dietary cholesterol and/or blood cholesterol and ASCVD. Consequently, the r...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Huang SS,Liu IH,Chen CL,Chang JM,Johnson FE,Huang JS

    更新日期:2017-06-01 00:00:00

  • Nuclear localization and Overexpression of Smoothened in Pancreatic and Colorectal Cancers.

    abstract::Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

    更新日期:2019-02-19 00:00:00

  • Membrane dynamics of γ-secretase with the anterior pharynx-defective 1B subunit.

    abstract::The four-subunit protease complex γ-secretase cleaves many single-pass transmembrane (TM) substrates, including Notch and β-amyloid precursor protein to generate amyloid-β (Aβ), central to Alzheimer's disease. Two of the subunits anterior pharynx-defective 1 (APH-1) and presenilin (PS) exist in two homologous forms AP...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Dehury B,Kepp KP

    更新日期:2021-01-01 00:00:00

  • Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF-κB in glomerular mesangial cells.

    abstract::Lipopolysaccharide (LPS) released from gram-negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS-induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Tsai KD,Lee WX,Chen W,Chen BY,Chen KL,Hsiao TC,Wang SH,Lee YJ,Liang SY,Shieh JC,Lin TH

    更新日期:2018-04-01 00:00:00

  • SCF FBXW17 E3 ubiquitin ligase regulates FBXL19 stability and cell migration.

    abstract::The Skp1-Cul1-F-box protein (SCF) E3 ligase complex is one of the largest ubiquitin E3 ligase families. FBXL19, a F-box protein in SCFFBXL19 E3 ligase complex, regulates a variety of cellular responses including cell migration. We have shown that FBXL19 is not stable and its degradation is mediated by the ubiquitin-pr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Dong S,Wei J,Bowser RK,Chen BB,Mallampalli RK,Miao J,Ye Q,Tran KC,Zhao Y,Zhao J

    更新日期:2020-10-14 00:00:00

  • "New"-clear functions of PDK1: beyond a master kinase in the cytosol?

    abstract::Activation of cytosolic phosphoinositide-3 kinase (PI-3K) signaling pathway has been well established to regulate gene expression, cell cycle, and survival by feeding signals to the nucleus. In addition, strong evidences accumulated over the past few years indicate the presence of an autonomous inositol lipid metaboli...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Kikani CK,Dong LQ,Liu F

    更新日期:2005-12-15 00:00:00

  • Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

    abstract::Chylomicrons play a role in atherosclerosis, however, because the mechanisms involved in the cell uptake of these particles are not fully understood, investigations were carried out using a radioactively labeled protein-free triacylglycerol-rich emulsion incubated with peritoneal macrophages obtained from normal and a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Carvalho MD,Harada LM,Gidlund M,Ketelhuth DF,Boschcov P,Quintão EC

    更新日期:2002-01-01 00:00:00

  • Inhibition of erythrocyte membrane shape change by band 3 cytoplasmic fragment.

    abstract::The ATP-dependent transformation of crenated white human erythrocyte ghosts into smoothed disc and cup forms is inhibited by the soluble 40-45-kilodalton (kDa) cytoplasmic portion of the major transmembrane protein, band 3. The band 3 fragment was prepared by chymotryptic treatment of inverted vesicles stripped of per...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Carter DP,Fairbanks G

    更新日期:1984-01-01 00:00:00

  • Prediction of platinum-resistance patients of gastric cancer using bioinformatics.

    abstract::Lack of guidelines for personalized chemotherapy treatment after surgery has caused gastric cancer (GC) patients' unnecessary exposure to toxicity and the financial burden of chemotherapy treatments. In our study, we aimed to identify potential biomarkers to predict GC patients' susceptibility to platinum-based on Gen...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Pan J,Xiang Z,Dai Q,Wang Z,Liu B,Li C

    更新日期:2019-08-01 00:00:00

  • Circular RNA circ-PRKCI functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-3680-3p in esophageal squamous cell carcinoma.

    abstract::Circular RNA (circRNA) is a new noncoding RNAs and plays an important role in many pathological processes. Recently, studies have shown that circular RNA_PRKCI (circ-PRKCI) regulates cell proliferation and cell migration of tumor cells. Esophageal carcinoma is a highly malignant digestive tract tumor, which is divided...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Shi N,Shan B,Gu B,Song Y,Chu H,Qian L

    更新日期:2019-06-01 00:00:00

  • Effects of heat shock on the distribution and expression levels of nuclear proteins in HeLa S3 cells.

    abstract::Cumulating evidence has led to the idea that nuclear functions such as DNA replication, RNA transcription, RNA splicing and nucleocytoplasmic transport are facilitated by a proteinaceous architectural framework within the nuclear compartment and at the nuclear envelope. In the present study, we have used immunofluores...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Haddad N,Paulin-Levasseur M

    更新日期:2008-12-15 00:00:00

  • Application of mass spectrometry to the discovery of biomarkers for detection of prostate cancer.

    abstract::There has been an impressive emergence of mass spectrometry based technologies applied toward the study of proteins. Equally notable is the rapid adaptation of these technologies to biomedical approaches in the realm of clinical proteomics. Concerted efforts toward the elucidation of the proteomes of organ sites or sp...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Semmes OJ,Malik G,Ward M

    更新日期:2006-06-01 00:00:00

  • Identification and characterization of various differentiative growth plate chondrocytes from porcine by countercurrent centrifugal elutriation.

    abstract::Countercurrent centrifugal elutriation was used to separate growth plate chondrocytes from porcine basing on their differences in sizes and densities. Eighteen fractions of cells with different sizes and densities were obtained. The mean cellular volumes increased progressively in each of successive fractions, and tha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lee KM,Fung KP,Leung PC,Leung KS

    更新日期:1996-03-15 00:00:00

  • Biochemical and molecular study on interleukin-1β gene expression and relation of single nucleotide polymorphism in promoter region with Type 2 diabetes mellitus.

    abstract::Interleukin-1β (IL-1β) assumes a centric role in the regulation of immune and inflammatory responses and thus has been recognized in immune mediated diseases like type 2 diabetes mellitus (T2DM). We aimed to investigate expressed level of IL-1β and its relation with IL-1β -511T>C polymorphism in T2DM patients. This st...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Tayel SI,Fouda EAM,Elshayeb EI,Eldakamawy ARA,El-Kousy SM

    更新日期:2018-07-01 00:00:00

  • Cactus-independent nuclear translocation of Drosophila RELISH.

    abstract::Insects can effectively and rapidly clear microbial infections by a variety of innate immune responses including the production of antimicrobial peptides. Induction of these antimicrobial peptides in Drosophila has been well established to involve NF-kappaB elements. We present evidence here for a molecular mechanism ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Cornwell WD,Kirkpatrick RB

    更新日期:2001-04-02 00:00:00

  • miR-99a suppresses the metastasis of human non-small cell lung cancer cells by targeting AKT1 signaling pathway.

    abstract::MicroRNAs (miRNAs) play an important role in the development and progression of non-small cell lung cancer (NSCLC). Recently, several studies have shown that miR-99a is downregulated in various cancers, which can affect tumor initiation and maintenance. Herein, we found that miR-99a was downregulated in NSCLC tissues ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yu SH,Zhang CL,Dong FS,Zhang YM

    更新日期:2015-02-01 00:00:00

  • Osteogenesis and expression of the bone marrow niche in endothelial cell-depleted HipOPs.

    abstract::The identification and purification of murine multipotent mesenchymal stem cells (MSCs) have been difficult due to their low frequency, the presence of contaminating cell types and lack of unambiguous markers. Using a magnetic micro-beads negative selection technique to remove hematopoietic cells from mouse bone marro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: McKenzie KP,Mayer DC,Aubin JE

    更新日期:2013-05-01 00:00:00

  • Monoclonal antibodies which alter the morphology of cultured chick myogenic cells.

    abstract::Two monoclonal antibodies that cause changes in the morphology of cultured myogenic cells are described. Antibody JG9 causes myoblasts to round up and causes myotubes to become thin, cable-like structures with multiple round swellings. Antibody JG22 causes both myoblasts and myotubes to become round refractile cells p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Greve JM,Gottlieb DI

    更新日期:1982-01-01 00:00:00

  • Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy via reducing B-cell translocation gene 2.

    abstract::Platelets are critical regulators of liver regeneration, but the mechanisms are still not fully understood. Platelets have been shown to contain a wide variety of microRNAs (miRNAs) and play an important role in many diseases. However, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Xu Y,Li W,Liang G,Peng J,Xu X

    更新日期:2020-07-21 00:00:00

  • Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4.

    abstract::Human eosinophil-derived neurotoxin (EDN, RNase2) and eosinophil cationic protein (ECP, RNase3) sequences possess as high as 92% identity in their promoter regions. The major difference within this region is a 34-nucleotide (34-nt) segment appeared only in the edn promoter. In addition, six discrete segments existed i...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang HY,Ho PC,Lan CY,Chang MD

    更新日期:2009-02-01 00:00:00

  • HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.

    abstract::Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses, and is often significantly overexpressed in solid tumors, but little is known of its role in human lung cancer. In this study, we demonstrated the aberrant expression of HDAC2 in lung cancer ti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jung KH,Noh JH,Kim JK,Eun JW,Bae HJ,Xie HJ,Chang YG,Kim MG,Park H,Lee JY,Nam SW

    更新日期:2012-06-01 00:00:00

  • Synthesis and Characterization of Cefotaxime Conjugated Gold Nanoparticles and Their Use to Target Drug-Resistant CTX-M-Producing Bacterial Pathogens.

    abstract::Multidrug-resistance due to "β lactamases having the expanded spectrum" (ESBLs) in members of Enterobacteriaceae is a matter of continued clinical concern. CTX-M is among the most common ESBLs in Enterobacteriaceae family. In the present study, a nanoformulation of cefotaxime was prepared using gold nanoparticles to c...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Shaikh S,Rizvi SMD,Shakil S,Hussain T,Alshammari TM,Ahmad W,Tabrez S,Al-Qahtani MH,Abuzenadah AM

    更新日期:2017-09-01 00:00:00

  • Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis.

    abstract::The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. Wilms' tumor 1-associating protein (WTAP) is initially identified as a nuclear protein that specifically interacts with WT1 in both in vitro and in vivo assays....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Xie W,Wei L,Guo J,Guo H,Song X,Sheng X

    更新日期:2019-02-12 00:00:00

  • Ulinastatin protects rats from sepsis-induced acute lung injury by suppressing the JAK-STAT3 pathway.

    abstract::Sepsis is usually accompanied by pulmonary inflammations, leading to acute lung injury. During this process, endogenous factors that play a regulatory role could be exploited to therapeutically alleviate such lethal tissue injury. Here, we showed that ulinastatin (UTI) administration could reduce lung tissue necrosis ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wu J,Yan X,Jin G

    更新日期:2018-09-22 00:00:00

  • Comparative Analysis of Human and Rodent Brain Primary Neuronal Culture Spontaneous Activity Using Micro-Electrode Array Technology.

    abstract::Electrical activity in embryonic brain tissue has typically been studied using Micro Electrode Array (MEA) technology to make dozens of simultaneous recordings from dissociated neuronal cultures, brain stem cell progenitors, or brain slices from fetal rodents. Although these rodent neuronal primary culture electrical ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Napoli A,Obeid I

    更新日期:2016-03-01 00:00:00

  • ClC-3 Promotes Osteogenic Differentiation in MC3T3-E1 Cell After Dynamic Compression.

    abstract::ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang D,Wang H,Gao F,Wang K,Dong F

    更新日期:2017-06-01 00:00:00

  • Evidence for ligand-independent homo-oligomerization of leptin receptor (OB-R) isoforms: a proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression.

    abstract::The adipocyte secreted hormone leptin (OB) and its receptor (OB-R) are key regulators of mammalian body weight homeostasis. Two predominant isoforms of OB-R have been described: long form (OB-R(L)) characterized as a signal transducing receptor that is highly expressed in specific nuclei of the hypothalamus; and a sho...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: White DW,Tartaglia LA

    更新日期:1999-05-01 00:00:00

  • Wip1 cooperates with KPNA2 to modulate the cell proliferation and migration of colorectal cancer via a p53-dependent manner.

    abstract::Due to the increasing incidence and mortality, the early diagnosis, specific targeted therapies, and prognosis for colorectal cancer (CRC) attract more and more attention. Wild-type p53-induced phosphatase 1 (Wip1) and karyopherin α2 (KPNA2) have been regarded as oncogenes in many cancers, including CRC. Wip1 dephosph...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang P,Zhao Y,Liu K,Liu X,Liang J,Zhou H,Wang Z,Zhou Z,Xu N

    更新日期:2019-09-01 00:00:00