Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: technique and prospective results.

Abstract:

PURPOSE:To evaluate magnetic resonance (MR) imaging-guided laser-induced thermotherapy (LITT) of liver metastases. MATERIALS AND METHODS:In a phase II study, 20 patients with 33 metastases from colorectal carcinoma (75%) or other primary tumors (25%) underwent LITT. MR thermometry performed with fast low-angle shot sequences was used to monitor therapy on-line, and dynamic and static contrast material-enhanced MR images enabled estimation of the degree of resultant necrosis. Follow-up studies were performed 3 months after thermotherapy. RESULTS:The thermosequences enabled accurate on-line monitoring in 85% of lesions. In 69% of lesions 20 mm in diameter or smaller, contrast-enhanced MR images depicted substantial necrosis, with a local tumor control rate of 69% after 6 months and 44% after 12 months. Among lesions larger than 20 mm, necrosis was frequently incomplete, with a local control rate of only 41% after 6 months and 27% after 12 months. CONCLUSION:MR imaging-guided LITT of liver metastases is a safe and promising therapy for liver metastases.

journal_name

Radiology

journal_title

Radiology

authors

Vogl TJ,Müller PK,Hammerstingl R,Weinhold N,Mack MG,Philipp C,Deimling M,Beuthan J,Pegios W,Riess H

doi

10.1148/radiology.196.1.7540310

subject

Has Abstract,Author List Incomplete

pub_date

1995-07-01 00:00:00

pages

257-65

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

196

pub_type

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