Abstract:
PURPOSE:To evaluate magnetic resonance (MR) imaging-guided laser-induced thermotherapy (LITT) of liver metastases. MATERIALS AND METHODS:In a phase II study, 20 patients with 33 metastases from colorectal carcinoma (75%) or other primary tumors (25%) underwent LITT. MR thermometry performed with fast low-angle shot sequences was used to monitor therapy on-line, and dynamic and static contrast material-enhanced MR images enabled estimation of the degree of resultant necrosis. Follow-up studies were performed 3 months after thermotherapy. RESULTS:The thermosequences enabled accurate on-line monitoring in 85% of lesions. In 69% of lesions 20 mm in diameter or smaller, contrast-enhanced MR images depicted substantial necrosis, with a local tumor control rate of 69% after 6 months and 44% after 12 months. Among lesions larger than 20 mm, necrosis was frequently incomplete, with a local control rate of only 41% after 6 months and 27% after 12 months. CONCLUSION:MR imaging-guided LITT of liver metastases is a safe and promising therapy for liver metastases.
journal_name
Radiologyjournal_title
Radiologyauthors
Vogl TJ,Müller PK,Hammerstingl R,Weinhold N,Mack MG,Philipp C,Deimling M,Beuthan J,Pegios W,Riess Hdoi
10.1148/radiology.196.1.7540310subject
Has Abstract,Author List Incompletepub_date
1995-07-01 00:00:00pages
257-65issue
1eissn
0033-8419issn
1527-1315journal_volume
196pub_type
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